SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ver'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		4 / 6 PRO A 105
LYS A 109
ALA A 323
GLU A 324
 None
 1.44A 1qhyA-5verA:
undetectable		 1qhyA-5verA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		3 / 3 LEU A 357
PHE A 447
ARG A 430
 None
None
EPE  A 702 (-3.1A)
 0.70A 1xdkF-5verA:
undetectable		 1xdkF-5verA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		4 / 5 ASP A 441
LEU A 440
MET A 354
ARG A 353
 None
 1.41A 2gj5A-5verA:
undetectable		 2gj5A-5verA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		5 / 12 LEU A 139
VAL A 249
ALA A 135
TYR A 136
TYR A 163
 None
None
PLP  A 701 (-3.4A)
PLP  A 701 (-4.7A)
None
 1.24A 2japA-5verA:
3.5		 2japA-5verA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		5 / 12 LEU A 139
VAL A 249
ALA A 135
TYR A 136
TYR A 163
 None
None
PLP  A 701 (-3.4A)
PLP  A 701 (-4.7A)
None
 1.22A 2japB-5verA:
3.4		 2japB-5verA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		5 / 12 LEU A 139
VAL A 249
ALA A 135
TYR A 136
TYR A 163
 None
None
PLP  A 701 (-3.4A)
PLP  A 701 (-4.7A)
None
 1.25A 2japC-5verA:
3.5		 2japC-5verA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		5 / 12 LEU A 139
VAL A 249
ALA A 135
TYR A 136
TYR A 163
 None
None
PLP  A 701 (-3.4A)
PLP  A 701 (-4.7A)
None
 1.22A 2japD-5verA:
3.4		 2japD-5verA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9W_A_PXLA1197_1
(ASPARTATE
AMINOTRANSFERASE)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		5 / 11 LEU A 139
TYR A 160
ASP A 247
VAL A 249
LYS A 281
 None
PLP  A 701 (-4.0A)
PLP  A 701 (-3.0A)
None
PLP  A 701 (-1.5A)
 1.05A 2z9wA-5verA:
19.8		 2z9wA-5verA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9W_B_PXLB1197_1
(ASPARTATE
AMINOTRANSFERASE)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		5 / 11 LEU A 139
TYR A 160
ASP A 247
VAL A 249
LYS A 281
 None
PLP  A 701 (-4.0A)
PLP  A 701 (-3.0A)
None
PLP  A 701 (-1.5A)
 1.02A 2z9wB-5verA:
21.3		 2z9wB-5verA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9X_B_PXLB2503_1
(ASPARTATE
AMINOTRANSFERASE)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		5 / 11 LEU A 139
TYR A 160
ASP A 247
VAL A 249
LYS A 281
 None
PLP  A 701 (-4.0A)
PLP  A 701 (-3.0A)
None
PLP  A 701 (-1.5A)
 1.18A 2z9xB-5verA:
21.9		 2z9xB-5verA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		4 / 5 PRO A 344
THR A 286
VAL A 285
GLY A 280
 None
 1.15A 3elzA-5verA:
undetectable		 3elzA-5verA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		4 / 4 ILE A 212
ARG A 168
ILE A 213
THR A 242
 None
 1.19A 3ia4C-5verA:
undetectable		 3ia4C-5verA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		3 / 3 LEU A 114
TRP A 292
GLY A 277
 None
 0.73A 3l35A-5verA:
undetectable
3l35H-5verA:
undetectable		 3l35A-5verA:
8.03
3l35H-5verA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		3 / 3 LEU A 114
TRP A 292
GLY A 277
 None
 0.76A 3l35B-5verA:
undetectable
3l35K-5verA:
undetectable		 3l35B-5verA:
8.03
3l35K-5verA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		4 / 7 TYR A 136
GLU A  56
PRO A 412
TYR A 396
 PLP  A 701 (-4.7A)
None
None
None
 1.18A 3ugrA-5verA:
undetectable		 3ugrA-5verA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		4 / 8 VAL A  53
TRP A  54
PHE A 416
PRO A 393
 None
EPE  A 702 (-3.8A)
None
None
 1.47A 3v35A-5verA:
undetectable		 3v35A-5verA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		4 / 6 PRO A  74
TYR A 372
TYR A 250
PHE A 373
 None
None
PLP  A 701 (-4.1A)
EPE  A 702 (-4.5A)
 1.15A 4g10A-5verA:
undetectable		 4g10A-5verA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		5 / 12 GLY A 222
GLY A 370
ILE A 374
ILE A 375
SER A 191
 None
 1.07A 4iv0B-5verA:
3.7		 4iv0B-5verA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		5 / 12 GLY A 222
GLY A 371
ILE A 374
ILE A 375
SER A 191
 None
 1.06A 4iv0B-5verA:
3.7		 4iv0B-5verA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		5 / 12 GLY A 222
GLY A 370
ILE A 374
ILE A 375
SER A 191
 None
 1.07A 4mwzA-5verA:
3.7		 4mwzA-5verA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		5 / 12 GLY A 222
GLY A 371
ILE A 374
ILE A 375
SER A 191
 None
 1.05A 4mwzA-5verA:
3.7		 4mwzA-5verA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		5 / 12 GLY A 134
ALA A 135
GLY A 137
LEU A 139
LEU A 303
 PLP  A 701 (-3.2A)
PLP  A 701 (-3.4A)
None
None
None
 0.83A 4o3fA-5verA:
undetectable		 4o3fA-5verA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		3 / 3 ASP A 437
LYS A 435
LEU A  69
 None
 1.02A 4ptjA-5verA:
undetectable		 4ptjA-5verA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		4 / 6 LEU A 440
LEU A 408
ILE A 374
PHE A 431
 None
 0.90A 4y4dA-5verA:
undetectable		 4y4dA-5verA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		4 / 5 PHE A 176
PRO A 178
VAL A 157
PHE A 425
 None
PGE  A 703 ( 4.9A)
None
PGE  A 703 ( 4.4A)
 1.31A 4z4cA-5verA:
undetectable		 4z4cA-5verA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		5 / 12 TYR A 250
GLY A 134
ALA A 135
SER A 138
LEU A 139
 PLP  A 701 (-4.1A)
PLP  A 701 (-3.2A)
PLP  A 701 (-3.4A)
None
None
 1.07A 5jvzA-5verA:
undetectable		 5jvzA-5verA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		5 / 12 TYR A 250
GLY A 134
ALA A 135
SER A 138
LEU A 139
 PLP  A 701 (-4.1A)
PLP  A 701 (-3.2A)
PLP  A 701 (-3.4A)
None
None
 1.07A 5jvzB-5verA:
undetectable		 5jvzB-5verA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		4 / 6 LEU A 358
MET A 402
THR A 403
LEU A 408
 None
 1.05A 5x1fA-5verA:
undetectable
5x1fJ-5verA:
undetectable		 5x1fA-5verA:
23.16
5x1fJ-5verA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3
(Mus
musculus) 		5 / 12 ILE A 233
PHE A 196
PRO A 217
THR A 216
LEU A 214
 None
 1.11A 5xxiA-5verA:
undetectable		 5xxiA-5verA:
23.24