SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5veu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		5 / 12 ILE A 303
PHE A 304
GLY A 306
SER A 311
LEU A 211
 None
RIT  A 602 (-3.7A)
HEM  A 601 ( 3.8A)
None
None
 1.00A 1fm6X-5veuA:
undetectable		 1fm6X-5veuA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		4 / 6 ASP A 270
LEU A 269
ILE A 276
ARG A 260
 None
 0.89A 1mt1A-5veuA:
undetectable
1mt1F-5veuA:
undetectable		 1mt1A-5veuA:
7.61
1mt1F-5veuA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		4 / 6 ILE A 276
ARG A 260
ASP A 270
LEU A 269
 None
 0.83A 1mt1B-5veuA:
undetectable
1mt1C-5veuA:
undetectable		 1mt1B-5veuA:
12.24
1mt1C-5veuA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		4 / 6 ASP A 270
LEU A 269
ILE A 276
ARG A 260
 None
 0.83A 1mt1G-5veuA:
undetectable
1mt1J-5veuA:
undetectable		 1mt1G-5veuA:
7.61
1mt1J-5veuA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		4 / 7 ASP A 270
LEU A 269
ILE A 276
ARG A 260
 None
 0.89A 1n13I-5veuA:
undetectable
1n13L-5veuA:
undetectable		 1n13I-5veuA:
7.61
1n13L-5veuA:
12.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		6 / 6 ARG A 105
SER A 119
ILE A 301
ALA A 305
THR A 309
ALA A 370
 HEM  A 601 (-2.8A)
RIT  A 602 (-3.7A)
RIT  A 602 ( 4.9A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
RIT  A 602 (-3.3A)
 0.69A 1w0gA-5veuA:
50.7		 1w0gA-5veuA:
83.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		4 / 5 PHE A 271
LEU A 290
PHE A 189
SER A 250
 None
 1.29A 1wrlC-5veuA:
undetectable		 1wrlC-5veuA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		3 / 3 PHE A 446
TYR A 179
TYR A 152
 HEM  A 601 ( 4.9A)
None
None
 0.70A 1x70B-5veuA:
undetectable		 1x70B-5veuA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		3 / 3 THR A 409
GLU A 362
HIS A 403
 None
 0.90A 1xwfA-5veuA:
undetectable		 1xwfA-5veuA:
21.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		5 / 12 ARG A 106
ALA A 305
ALA A 370
ARG A 372
GLU A 374
 RIT  A 602 ( 4.0A)
HEM  A 601 (-3.4A)
RIT  A 602 (-3.3A)
None
RIT  A 602 ( 4.8A)
 1.00A 2j0dA-5veuA:
50.1		 2j0dA-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		5 / 12 ARG A 106
ALA A 305
THR A 309
ALA A 370
GLU A 374
 RIT  A 602 ( 4.0A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
RIT  A 602 (-3.3A)
RIT  A 602 ( 4.8A)
 0.92A 2j0dA-5veuA:
50.1		 2j0dA-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		5 / 12 ILE A 301
ALA A 305
ALA A 370
ARG A 372
GLU A 374
 RIT  A 602 ( 4.9A)
HEM  A 601 (-3.4A)
RIT  A 602 (-3.3A)
None
RIT  A 602 ( 4.8A)
 1.11A 2j0dA-5veuA:
50.1		 2j0dA-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		5 / 12 ILE A 301
ALA A 305
THR A 309
ALA A 370
GLU A 374
 RIT  A 602 ( 4.9A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
RIT  A 602 (-3.3A)
RIT  A 602 ( 4.8A)
 1.04A 2j0dA-5veuA:
50.1		 2j0dA-5veuA:
83.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		4 / 7 ILE A 276
ARG A 260
ASP A 270
LEU A 269
 None
 0.85A 2qqcB-5veuA:
undetectable
2qqcC-5veuA:
undetectable		 2qqcB-5veuA:
12.66
2qqcC-5veuA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		4 / 7 ASP A 270
LEU A 269
ILE A 276
ARG A 260
 None
 0.81A 2qqcA-5veuA:
undetectable
2qqcF-5veuA:
undetectable		 2qqcA-5veuA:
7.61
2qqcF-5veuA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		4 / 7 ASP A 270
LEU A 269
ILE A 276
ARG A 260
 None
 0.82A 2qqcG-5veuA:
undetectable
2qqcJ-5veuA:
undetectable		 2qqcG-5veuA:
7.61
2qqcJ-5veuA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		4 / 7 ASP A 270
LEU A 269
ILE A 276
ARG A 260
 None
 0.83A 2qqcI-5veuA:
undetectable
2qqcL-5veuA:
undetectable		 2qqcI-5veuA:
7.61
2qqcL-5veuA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		4 / 7 ASP A 270
LEU A 269
ILE A 276
ARG A 260
 None
 0.93A 2qqdA-5veuA:
undetectable
2qqdE-5veuA:
undetectable		 2qqdA-5veuA:
7.40
2qqdE-5veuA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		4 / 6 ILE A 276
LEU A 261
LEU A 295
ASP A 292
 None
 1.06A 2rlfA-5veuA:
undetectable
2rlfD-5veuA:
undetectable		 2rlfA-5veuA:
9.07
2rlfD-5veuA:
9.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		6 / 11 ARG A 105
SER A 119
ILE A 301
ALA A 305
GLU A 374
LEU A 481
 HEM  A 601 (-2.8A)
RIT  A 602 (-3.7A)
RIT  A 602 ( 4.9A)
HEM  A 601 (-3.4A)
RIT  A 602 ( 4.8A)
None
 0.67A 2v0mA-5veuA:
56.5		 2v0mA-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		6 / 11 ARG A 105
SER A 119
ILE A 301
PHE A 304
ALA A 305
LEU A 481
 HEM  A 601 (-2.8A)
RIT  A 602 (-3.7A)
RIT  A 602 ( 4.9A)
RIT  A 602 (-3.7A)
HEM  A 601 (-3.4A)
None
 0.73A 2v0mA-5veuA:
56.5		 2v0mA-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		6 / 11 PHE A 215
ARG A 105
ILE A 301
PHE A 304
ALA A 305
LEU A 481
 RIT  A 602 (-4.0A)
HEM  A 601 (-2.8A)
RIT  A 602 ( 4.9A)
RIT  A 602 (-3.7A)
HEM  A 601 (-3.4A)
None
 1.49A 2v0mA-5veuA:
56.5		 2v0mA-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		6 / 11 SER A 119
ILE A 301
PHE A 304
ALA A 305
ARG A 372
LEU A 481
 RIT  A 602 (-3.7A)
RIT  A 602 ( 4.9A)
RIT  A 602 (-3.7A)
HEM  A 601 (-3.4A)
None
None
 0.97A 2v0mA-5veuA:
56.5		 2v0mA-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		7 / 12 ARG A 105
SER A 119
PHE A 241
ILE A 301
ALA A 305
THR A 309
GLU A 374
 HEM  A 601 (-2.8A)
RIT  A 602 (-3.7A)
RIT  A 602 (-3.9A)
RIT  A 602 ( 4.9A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
RIT  A 602 ( 4.8A)
 0.72A 2v0mC-5veuA:
48.7		 2v0mC-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		6 / 12 SER A 119
PHE A 241
ILE A 301
ALA A 305
THR A 309
ARG A 372
 RIT  A 602 (-3.7A)
RIT  A 602 (-3.9A)
RIT  A 602 ( 4.9A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
None
 0.78A 2v0mC-5veuA:
48.7		 2v0mC-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		7 / 11 ARG A 105
SER A 119
ILE A 301
ALA A 305
THR A 309
GLU A 374
LEU A 481
 HEM  A 601 (-2.8A)
RIT  A 602 (-3.7A)
RIT  A 602 ( 4.9A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
RIT  A 602 ( 4.8A)
None
 0.65A 2v0mD-5veuA:
56.5		 2v0mD-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		7 / 11 ARG A 105
SER A 119
ILE A 301
PHE A 304
ALA A 305
THR A 309
LEU A 481
 HEM  A 601 (-2.8A)
RIT  A 602 (-3.7A)
RIT  A 602 ( 4.9A)
RIT  A 602 (-3.7A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
None
 0.65A 2v0mD-5veuA:
56.5		 2v0mD-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		7 / 11 SER A 119
ILE A 301
PHE A 304
ALA A 305
THR A 309
ARG A 372
LEU A 481
 RIT  A 602 (-3.7A)
RIT  A 602 ( 4.9A)
RIT  A 602 (-3.7A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
None
None
 0.95A 2v0mD-5veuA:
56.5		 2v0mD-5veuA:
83.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		5 / 12 LEU A 455
LEU A 459
GLN A 332
VAL A 327
MET A 353
 None
 1.43A 2yloA-5veuA:
undetectable		 2yloA-5veuA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		4 / 5 GLN A 298
ALA A 117
ILE A 118
ARG A 439
 None
None
HEM  A 601 (-4.1A)
HEM  A 601 (-3.9A)
 1.31A 2z0aA-5veuA:
undetectable		 2z0aA-5veuA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		4 / 5 LEU A 490
GLN A 471
THR A 470
THR A 317
 None
 1.20A 2zj0B-5veuA:
undetectable		 2zj0B-5veuA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		4 / 4 LEU A 490
GLN A 471
THR A 470
THR A 317
 None
 1.32A 2zj0D-5veuA:
undetectable		 2zj0D-5veuA:
22.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		3 / 3 ALA A 305
THR A 309
CYH A 441
 HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
HEM  A 601 (-2.2A)
 0.70A 3e4eA-5veuA:
37.4		 3e4eA-5veuA:
30.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		3 / 3 ALA A 305
THR A 309
CYH A 441
 HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
HEM  A 601 (-2.2A)
 0.66A 3e4eB-5veuA:
37.2		 3e4eB-5veuA:
30.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_E_C2FE995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		5 / 11 THR A 136
SER A 281
GLN A 279
LEU A 132
ARG A 128
 None
 1.48A 3fsuE-5veuA:
undetectable		 3fsuE-5veuA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		5 / 12 ARG A 105
PHE A 271
SER A 188
THR A 187
ALA A 305
 HEM  A 601 (-2.8A)
None
None
None
HEM  A 601 (-3.4A)
 1.29A 3lcvB-5veuA:
undetectable		 3lcvB-5veuA:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		5 / 12 PHE A 215
PHE A 241
PHE A 304
ALA A 305
GLY A 480
 RIT  A 602 (-4.0A)
RIT  A 602 (-3.9A)
RIT  A 602 (-3.7A)
HEM  A 601 (-3.4A)
RIT  A 602 ( 3.7A)
 1.06A 3nxuA-5veuA:
49.3		 3nxuA-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		5 / 12 SER A 119
ILE A 301
ALA A 305
ALA A 370
GLY A 480
 RIT  A 602 (-3.7A)
RIT  A 602 ( 4.9A)
HEM  A 601 (-3.4A)
RIT  A 602 (-3.3A)
RIT  A 602 ( 3.7A)
 0.87A 3nxuA-5veuA:
49.3		 3nxuA-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		6 / 12 SER A 119
PHE A 241
ILE A 301
PHE A 304
ALA A 305
GLY A 480
 RIT  A 602 (-3.7A)
RIT  A 602 (-3.9A)
RIT  A 602 ( 4.9A)
RIT  A 602 (-3.7A)
HEM  A 601 (-3.4A)
RIT  A 602 ( 3.7A)
 0.48A 3nxuA-5veuA:
49.3		 3nxuA-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		5 / 12 MET A 114
PHE A 215
PHE A 241
PHE A 304
ALA A 305
 None
RIT  A 602 (-4.0A)
RIT  A 602 (-3.9A)
RIT  A 602 (-3.7A)
HEM  A 601 (-3.4A)
 0.77A 3nxuB-5veuA:
48.9		 3nxuB-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		5 / 12 MET A 114
SER A 119
ILE A 301
ALA A 305
ALA A 370
 None
RIT  A 602 (-3.7A)
RIT  A 602 ( 4.9A)
HEM  A 601 (-3.4A)
RIT  A 602 (-3.3A)
 0.73A 3nxuB-5veuA:
48.9		 3nxuB-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		6 / 12 MET A 114
SER A 119
PHE A 241
ILE A 301
PHE A 304
ALA A 305
 None
RIT  A 602 (-3.7A)
RIT  A 602 (-3.9A)
RIT  A 602 ( 4.9A)
RIT  A 602 (-3.7A)
HEM  A 601 (-3.4A)
 0.41A 3nxuB-5veuA:
48.9		 3nxuB-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		5 / 9 ARG A 105
THR A 309
LEU A 373
GLU A 374
GLY A 480
 HEM  A 601 (-2.8A)
HEM  A 601 ( 3.5A)
HEM  A 601 ( 4.2A)
RIT  A 602 ( 4.8A)
RIT  A 602 ( 3.7A)
 0.85A 3nxuB-5veuA:
48.9		 3nxuB-5veuA:
83.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		5 / 12 SER A 180
LEU A 160
VAL A 492
PHE A 464
VAL A 458
 None
 1.41A 3u9fH-5veuA:
undetectable
3u9fI-5veuA:
undetectable		 3u9fH-5veuA:
17.43
3u9fI-5veuA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		5 / 9 SER A 180
LEU A 160
VAL A 492
PHE A 464
VAL A 458
 None
 1.49A 3u9fP-5veuA:
undetectable		 3u9fP-5veuA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		5 / 10 SER A 180
LEU A 160
VAL A 492
PHE A 464
VAL A 458
 None
 1.49A 3u9fR-5veuA:
undetectable		 3u9fR-5veuA:
17.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		5 / 12 ARG A 105
ARG A 106
ALA A 305
THR A 309
ALA A 370
 HEM  A 601 (-2.8A)
RIT  A 602 ( 4.0A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
RIT  A 602 (-3.3A)
 0.92A 3ua1A-5veuA:
52.7		 3ua1A-5veuA:
83.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		5 / 12 ARG A 105
SER A 119
ALA A 305
THR A 309
ALA A 370
 HEM  A 601 (-2.8A)
RIT  A 602 (-3.7A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
RIT  A 602 (-3.3A)
 0.89A 3ua1A-5veuA:
52.7		 3ua1A-5veuA:
83.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		5 / 12 ARG A 106
PHE A 304
ALA A 305
THR A 309
ALA A 370
 RIT  A 602 ( 4.0A)
RIT  A 602 (-3.7A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
RIT  A 602 (-3.3A)
 1.07A 3ua1A-5veuA:
52.7		 3ua1A-5veuA:
83.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		3 / 3 ASP A 424
TRP A 408
SER A 420
 None
 1.01A 4lrhB-5veuA:
undetectable		 4lrhB-5veuA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		3 / 3 ASP A 424
TRP A 408
SER A 420
 None
 1.00A 4lrhF-5veuA:
undetectable		 4lrhF-5veuA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		5 / 12 PHE A 316
HIS A 403
LEU A 476
LEU A 482
TYR A 399
 None
 1.32A 4xumA-5veuA:
2.0		 4xumA-5veuA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		3 / 3 LEU A 211
TYR A 307
SER A 312
 None
 0.90A 5iktA-5veuA:
0.9		 5iktA-5veuA:
23.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		4 / 8 ARG A 105
ALA A 305
ALA A 370
LEU A 481
 HEM  A 601 (-2.8A)
HEM  A 601 (-3.4A)
RIT  A 602 (-3.3A)
None
 0.71A 5te8B-5veuA:
26.1		 5te8B-5veuA:
83.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		4 / 8 ARG A 105
SER A 119
ALA A 370
LEU A 481
 HEM  A 601 (-2.8A)
RIT  A 602 (-3.7A)
RIT  A 602 (-3.3A)
None
 0.80A 5te8B-5veuA:
26.1		 5te8B-5veuA:
83.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		7 / 12 SER A 119
PHE A 241
ILE A 301
PHE A 304
ALA A 305
THR A 309
ALA A 370
 RIT  A 602 (-3.7A)
RIT  A 602 (-3.9A)
RIT  A 602 ( 4.9A)
RIT  A 602 (-3.7A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
RIT  A 602 (-3.3A)
 0.74A 5vceA-5veuA:
53.9		 5vceA-5veuA:
82.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		5 / 12 PHE A 304
ALA A 305
THR A 309
ALA A 370
GLU A 374
 RIT  A 602 (-3.7A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
RIT  A 602 (-3.3A)
RIT  A 602 ( 4.8A)
 1.05A 5vcgA-5veuA:
52.9		 5vcgA-5veuA:
82.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		5 / 12 VAL A 183
PHE A 446
LEU A 481
VAL A 369
GLY A 443
 None
HEM  A 601 ( 4.9A)
None
HEM  A 601 ( 4.9A)
HEM  A 601 ( 4.0A)
 1.39A 6brdA-5veuA:
undetectable		 6brdA-5veuA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		4 / 6 LEU A 272
GLY A 190
ARG A 260
ARG A 268
 None
 1.34A 6gtqB-5veuA:
undetectable
6gtqD-5veuA:
undetectable		 6gtqB-5veuA:
18.11
6gtqD-5veuA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		5 / 10 LEU A 236
VAL A 238
VAL A 232
ILE A 223
LEU A 219
 None
 1.31A 6h1lA-5veuA:
38.2		 6h1lA-5veuA:
29.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		5 / 6 ARG A 105
SER A 119
ALA A 305
THR A 309
ALA A 370
 HEM  A 601 (-2.8A)
RIT  A 602 (-3.7A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
RIT  A 602 (-3.3A)
 0.75A 6ma6A-5veuA:
52.3		 6ma6A-5veuA:
76.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		4 / 7 ARG A 105
ALA A 305
THR A 309
ALA A 370
 HEM  A 601 (-2.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
RIT  A 602 (-3.3A)
 0.70A 6ma7A-5veuA:
52.0		 6ma7A-5veuA:
76.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 5veu CYTOCHROME P450 3A5
(Homo
sapiens) 		4 / 7 ARG A 105
SER A 119
THR A 309
ALA A 370
 HEM  A 601 (-2.8A)
RIT  A 602 (-3.7A)
HEM  A 601 ( 3.5A)
RIT  A 602 (-3.3A)
 0.66A 6ma7A-5veuA:
52.0		 6ma7A-5veuA:
76.25