SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vev'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Neisseria
gonorrhoeae) 		5 / 11 THR A 294
THR A  37
GLY A   9
VAL A   5
VAL A  30
 None
 1.22A 1akdA-5vevA:
undetectable		 1akdA-5vevA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Neisseria
gonorrhoeae) 		4 / 4 ILE A 196
MET A 298
VAL A   5
GLY A 290
 None
 1.33A 1e06B-5vevA:
undetectable		 1e06B-5vevA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Neisseria
gonorrhoeae) 		3 / 3 ALA A 129
HIS A 130
VAL A 133
 None
 0.27A 1lqtB-5vevA:
5.0		 1lqtB-5vevA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Neisseria
gonorrhoeae) 		3 / 3 ALA A 129
HIS A 130
VAL A 133
 None
 0.26A 1lquB-5vevA:
4.6		 1lquB-5vevA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Neisseria
gonorrhoeae) 		4 / 7 VAL A  79
LEU A 268
ALA A  97
LEU A  74
 None
 0.71A 1pthA-5vevA:
undetectable		 1pthA-5vevA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Neisseria
gonorrhoeae) 		4 / 7 VAL A  79
LEU A 268
ALA A  97
LEU A  74
 None
 0.71A 1pthB-5vevA:
undetectable		 1pthB-5vevA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Neisseria
gonorrhoeae) 		4 / 8 THR A 367
GLY A  36
THR A  37
ALA A  38
 None
 0.70A 2a1hA-5vevA:
undetectable
2a1hB-5vevA:
undetectable		 2a1hA-5vevA:
23.02
2a1hB-5vevA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Neisseria
gonorrhoeae) 		5 / 11 THR A 294
THR A  37
GLY A   9
VAL A   5
VAL A  30
 None
 1.14A 2a1nA-5vevA:
undetectable		 2a1nA-5vevA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Neisseria
gonorrhoeae) 		5 / 10 THR A 294
THR A  37
GLY A   9
VAL A   5
VAL A  30
 None
 1.22A 2cp4A-5vevA:
undetectable		 2cp4A-5vevA:
24.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Neisseria
gonorrhoeae) 		5 / 8 ASP A 212
LYS A 214
GLY A 290
PRO A 292
GLU A 293
 NA  A 501 (-3.1A)
NA  A 501 (-3.2A)
None
NA  A 501 (-4.4A)
NA  A 501 (-2.6A)
 0.55A 2ys6A-5vevA:
55.3		 2ys6A-5vevA:
50.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Neisseria
gonorrhoeae) 		5 / 10 THR A 294
THR A  37
GLY A   9
VAL A   5
VAL A  30
 None
 1.32A 3lxiA-5vevA:
undetectable		 3lxiA-5vevA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Neisseria
gonorrhoeae) 		5 / 10 VAL A 333
ALA A 364
THR A 366
ILE A 349
PHE A 407
 None
 1.24A 3t3qB-5vevA:
undetectable		 3t3qB-5vevA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Neisseria
gonorrhoeae) 		5 / 10 VAL A 333
ALA A 364
THR A 366
ILE A 349
PHE A 407
 None
 1.21A 3t3qC-5vevA:
undetectable		 3t3qC-5vevA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Neisseria
gonorrhoeae) 		5 / 10 VAL A 333
ALA A 364
THR A 366
ILE A 349
PHE A 407
 None
 1.26A 3t3qD-5vevA:
undetectable		 3t3qD-5vevA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Neisseria
gonorrhoeae) 		5 / 12 ASP A 291
ALA A 364
ASN A  34
ILE A 416
ARG A 380
 None
None
None
None
SO4  A 511 (-3.8A)
 1.29A 3wemA-5vevA:
undetectable		 3wemA-5vevA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Neisseria
gonorrhoeae) 		5 / 12 ASP A 291
ALA A 364
ASN A  34
ILE A 416
ARG A 380
 None
None
None
None
SO4  A 511 (-3.8A)
 1.29A 3wenA-5vevA:
undetectable		 3wenA-5vevA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Neisseria
gonorrhoeae) 		5 / 12 ASP A 291
ALA A 364
ASN A  34
ILE A 416
ARG A 380
 None
None
None
None
SO4  A 511 (-3.8A)
 1.29A 3weoA-5vevA:
undetectable		 3weoA-5vevA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Neisseria
gonorrhoeae) 		5 / 10 THR A 294
THR A  37
GLY A   9
VAL A   5
VAL A  30
 None
 1.32A 4c9nB-5vevA:
undetectable		 4c9nB-5vevA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Neisseria
gonorrhoeae) 		5 / 9 THR A 294
THR A  37
GLY A   9
VAL A   5
VAL A  30
 None
 1.33A 4c9pA-5vevA:
undetectable		 4c9pA-5vevA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Neisseria
gonorrhoeae) 		5 / 10 THR A 294
THR A  37
GLY A   9
VAL A   5
VAL A  30
 None
 1.36A 4c9pB-5vevA:
undetectable		 4c9pB-5vevA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Neisseria
gonorrhoeae) 		4 / 5 LEU A  15
LEU A 305
MET A 198
TRP A 324
 None
None
None
EDO  A 506 ( 4.6A)
 1.38A 4do3A-5vevA:
2.6		 4do3A-5vevA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Neisseria
gonorrhoeae) 		4 / 6 GLU A 185
GLU A 192
ASN A 224
ARG A 215
 None
 1.41A 4ntxA-5vevA:
undetectable
4ntxC-5vevA:
undetectable		 4ntxA-5vevA:
24.35
4ntxC-5vevA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Neisseria
gonorrhoeae) 		4 / 7 ILE A 196
PHE A 264
GLY A 266
LEU A  74
 None
 0.93A 4zdzA-5vevA:
undetectable		 4zdzA-5vevA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Neisseria
gonorrhoeae) 		5 / 9 VAL A 384
VAL A 361
ILE A 349
PHE A 407
LEU A 334
 None
 1.24A 5e4dA-5vevA:
undetectable		 5e4dA-5vevA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Neisseria
gonorrhoeae) 		4 / 7 ILE A 196
PHE A 264
GLY A 266
LEU A  74
 None
 0.87A 5esmA-5vevA:
undetectable		 5esmA-5vevA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Neisseria
gonorrhoeae) 		4 / 7 LEU A 272
ILE A 283
THR A 282
PHE A 289
 None
 1.00A 5zsfA-5vevA:
undetectable
5zsfB-5vevA:
undetectable		 5zsfA-5vevA:
11.73
5zsfB-5vevA:
11.73