SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vew'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 5vew GLUCAGON-LIKE
PEPTIDE 1
RECEPTOR,ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		3 / 3 VAL A 276
TRP A 274
TRP A 243
 None
 1.30A 1c4dA-5vewA:
undetectable
1c4dB-5vewA:
undetectable		 1c4dA-5vewA:
3.08
1c4dB-5vewA:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 5vew GLUCAGON-LIKE
PEPTIDE 1
RECEPTOR,ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 6 TYR A 402
VAL A 327
ILE A 323
LEU A 360
 None
 1.20A 1j96A-5vewA:
undetectable		 1j96A-5vewA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5vew GLUCAGON-LIKE
PEPTIDE 1
RECEPTOR,ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		3 / 3 LEU A 244
HIS A 180
ILE A 179
 None
 0.60A 1s9pB-5vewA:
undetectable		 1s9pB-5vewA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5vew GLUCAGON-LIKE
PEPTIDE 1
RECEPTOR,ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 9 GLY A 151
ALA A 153
SER A 155
LEU A 154
PHE A 195
 None
 1.44A 1y7iA-5vewA:
undetectable		 1y7iA-5vewA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5vew GLUCAGON-LIKE
PEPTIDE 1
RECEPTOR,ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 ALA A1129
PHE A1153
LEU A1133
ALA A1130
ILE A1078
 None
 0.95A 2aclA-5vewA:
2.1
2aclE-5vewA:
2.1		 2aclA-5vewA:
20.22
2aclE-5vewA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 5vew GLUCAGON-LIKE
PEPTIDE 1
RECEPTOR,ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 9 VAL A 331
LEU A 251
ILE A 345
LEU A 349
ALA A 350
 97Y  A1201 (-4.6A)
None
None
None
None
 0.96A 2z0yA-5vewA:
undetectable		 2z0yA-5vewA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5vew GLUCAGON-LIKE
PEPTIDE 1
RECEPTOR,ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 11 ALA A1129
PHE A1153
LEU A1133
ALA A1130
ILE A1078
 None
 1.00A 3fc6A-5vewA:
3.1		 3fc6A-5vewA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_1
(GLUCOCORTICOID
RECEPTOR)		 5vew GLUCAGON-LIKE
PEPTIDE 1
RECEPTOR,ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 10 ASN A1132
TRP A1138
MET A1102
LEU A1099
LEU A1133
 None
 1.49A 3h52B-5vewA:
undetectable		 3h52B-5vewA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5vew GLUCAGON-LIKE
PEPTIDE 1
RECEPTOR,ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 7 LEU A 166
CYH A 403
ASN A 406
THR A 355
 None
None
97Y  A1201 (-3.8A)
97Y  A1201 (-3.3A)
 1.03A 3lm8B-5vewA:
undetectable
3lm8D-5vewA:
undetectable		 3lm8B-5vewA:
19.38
3lm8D-5vewA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5vew GLUCAGON-LIKE
PEPTIDE 1
RECEPTOR,ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 6 ILE A 400
LEU A 183
PHE A 184
HIS A 180
 None
 1.02A 5vkqA-5vewA:
3.9
5vkqB-5vewA:
3.9		 5vkqA-5vewA:
15.13
5vkqB-5vewA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5vew GLUCAGON-LIKE
PEPTIDE 1
RECEPTOR,ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 6 ILE A 400
LEU A 183
PHE A 184
HIS A 180
 None
 1.02A 5vkqA-5vewA:
3.9
5vkqD-5vewA:
3.9		 5vkqA-5vewA:
15.13
5vkqD-5vewA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 5vew GLUCAGON-LIKE
PEPTIDE 1
RECEPTOR,ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		3 / 3 ARG A 348
ARG A1095
ARG A 176
 None
 1.08A 6bplA-5vewA:
3.6
6bplB-5vewA:
3.7		 6bplA-5vewA:
11.87
6bplB-5vewA:
11.87