SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vf4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		3 / 3 ALA A  90
VAL A 373
TRP A 201
 None
 0.85A 1av2A-5vf4A:
undetectable
1av2B-5vf4A:
undetectable		 1av2A-5vf4A:
6.06
1av2B-5vf4A:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		3 / 3 TRP A 201
ALA A  90
VAL A 373
 None
 0.73A 1av2C-5vf4A:
undetectable
1av2D-5vf4A:
undetectable		 1av2C-5vf4A:
6.06
1av2D-5vf4A:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		5 / 12 ALA A 297
THR A 279
LEU A 253
LEU A 207
LEU A 304
 None
 1.31A 1eiiA-5vf4A:
undetectable		 1eiiA-5vf4A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		5 / 11 VAL A  32
SER A  83
LEU A  34
ALA A 102
SER A 105
 None
 1.16A 1eqgB-5vf4A:
undetectable		 1eqgB-5vf4A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		5 / 10 LEU A 253
LYS A 254
VAL A 306
GLY A 307
LEU A 316
 None
 1.21A 1fk9A-5vf4A:
undetectable		 1fk9A-5vf4A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_E_BEZE1162_0
(PEROXIREDOXIN 5)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		5 / 9 THR A 187
PRO A 188
GLY A 190
ARG A  35
GLY A  18
 None
 1.41A 1h4oE-5vf4A:
undetectable
1h4oF-5vf4A:
undetectable		 1h4oE-5vf4A:
19.39
1h4oF-5vf4A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		4 / 4 GLY A 137
ASP A 193
GLY A 190
THR A 124
 None
 0.91A 1hxbB-5vf4A:
undetectable		 1hxbB-5vf4A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		4 / 8 ASP A  88
SER A 156
GLY A 168
THR A 164
 None
 0.85A 1jr1B-5vf4A:
undetectable		 1jr1B-5vf4A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		3 / 3 ARG A 370
ILE A  93
TRP A 201
 None
 1.13A 1nodB-5vf4A:
undetectable		 1nodB-5vf4A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		4 / 5 GLY A  29
GLN A  30
VAL A  32
SER A 105
 None
 1.03A 1p6kB-5vf4A:
undetectable		 1p6kB-5vf4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		4 / 6 GLY A  29
GLN A  30
VAL A  32
SER A 105
 None
 1.03A 1rs7B-5vf4A:
undetectable		 1rs7B-5vf4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		3 / 3 ALA A  90
VAL A 373
TRP A 201
 None
 0.86A 1w5uA-5vf4A:
undetectable
1w5uB-5vf4A:
undetectable		 1w5uA-5vf4A:
6.06
1w5uB-5vf4A:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		3 / 3 TRP A 201
ALA A  90
VAL A 373
 None
 0.83A 1w5uA-5vf4A:
undetectable
1w5uB-5vf4A:
undetectable		 1w5uA-5vf4A:
6.06
1w5uB-5vf4A:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		4 / 6 ALA A 375
GLU A 200
ILE A 344
LEU A 111
 None
CA  A 402 (-3.8A)
None
None
 0.89A 1xvaA-5vf4A:
undetectable
1xvaB-5vf4A:
undetectable		 1xvaA-5vf4A:
23.70
1xvaB-5vf4A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		4 / 5 GLY A 251
PRO A 313
VAL A 312
ILE A 310
 None
 0.80A 2aoiA-5vf4A:
undetectable		 2aoiA-5vf4A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		3 / 3 ALA A  90
VAL A 373
TRP A 201
 None
 0.74A 2izqA-5vf4A:
undetectable
2izqB-5vf4A:
undetectable		 2izqA-5vf4A:
6.06
2izqB-5vf4A:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		3 / 3 TRP A 201
ALA A  90
VAL A 373
 None
 0.83A 2izqC-5vf4A:
undetectable
2izqD-5vf4A:
undetectable		 2izqC-5vf4A:
6.06
2izqD-5vf4A:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		3 / 3 ARG A 370
ILE A  93
TRP A 201
 None
 1.09A 2nodB-5vf4A:
undetectable		 2nodB-5vf4A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y4N_B_PACB503_0
(PHENYLACETATE-COENZY
ME A LIGASE)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		4 / 4 SER A 144
GLY A 346
GLY A 331
LYS A 330
 None
CA  A 402 ( 4.4A)
None
None
 1.41A 2y4nB-5vf4A:
undetectable		 2y4nB-5vf4A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		5 / 12 ILE A 212
ASN A 218
LEU A 316
ALA A 322
LEU A 360
 None
 1.19A 3a50A-5vf4A:
undetectable		 3a50A-5vf4A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		5 / 12 ALA A 378
ILE A  67
ILE A  82
SER A  83
GLU A  80
 None
 1.24A 3axtA-5vf4A:
undetectable		 3axtA-5vf4A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		3 / 3 ARG A 370
ILE A  93
TRP A 201
 None
 1.14A 3e7iB-5vf4A:
undetectable		 3e7iB-5vf4A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_D_486D2_2
(GLUCOCORTICOID
RECEPTOR)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		4 / 5 LEU A 319
ASN A 114
TRP A 234
TYR A 255
 None
 1.46A 3h52D-5vf4A:
0.0		 3h52D-5vf4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		4 / 4 GLY A 137
ASP A 193
GLY A 190
THR A 124
 None
 0.89A 3k4vC-5vf4A:
undetectable		 3k4vC-5vf4A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		3 / 3 TRP A 201
ALA A  90
VAL A 373
 None
 0.66A 3l8lA-5vf4A:
undetectable
3l8lB-5vf4A:
undetectable		 3l8lA-5vf4A:
6.06
3l8lB-5vf4A:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		3 / 3 TRP A 201
ALA A  90
VAL A 373
 None
 0.86A 3l8lC-5vf4A:
undetectable
3l8lD-5vf4A:
undetectable		 3l8lC-5vf4A:
6.06
3l8lD-5vf4A:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		3 / 3 ARG A 370
ILE A  93
TRP A 201
 None
 1.06A 3nw2A-5vf4A:
undetectable		 3nw2A-5vf4A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		3 / 3 ARG A 370
ILE A  93
TRP A 201
 None
 1.06A 3nw2B-5vf4A:
undetectable		 3nw2B-5vf4A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		4 / 7 ASN A 218
ALA A  56
ARG A 376
ALA A 378
 None
 1.15A 3twpA-5vf4A:
undetectable		 3twpA-5vf4A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		5 / 12 VAL A 312
ALA A 236
LEU A 319
LEU A 316
LEU A 207
 None
 1.18A 4i1rA-5vf4A:
undetectable		 4i1rA-5vf4A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		5 / 12 GLY A 367
ASN A  94
SER A 290
TYR A 293
ARG A 206
 None
 1.31A 4kowA-5vf4A:
undetectable		 4kowA-5vf4A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		4 / 8 ARG A 128
ASP A 133
SER A 144
ARG A 136
 None
None
None
ACT  A 403 ( 4.2A)
 1.16A 4lv9A-5vf4A:
undetectable
4lv9B-5vf4A:
undetectable		 4lv9A-5vf4A:
21.90
4lv9B-5vf4A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		4 / 8 ALA A 236
GLU A 211
ASP A 256
ILE A 310
 None
 0.81A 4ndnB-5vf4A:
undetectable		 4ndnB-5vf4A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		4 / 5 TYR A 334
ARG A 332
ASP A 303
VAL A 312
 None
 1.47A 4nkvB-5vf4A:
undetectable		 4nkvB-5vf4A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		4 / 5 LEU A 333
LEU A 207
THR A 276
ARG A 238
 None
 1.00A 6ew0F-5vf4A:
undetectable		 6ew0F-5vf4A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5vf4 UNCHARACTERIZED
PROTEIN
(Thermus
aquaticus) 		4 / 7 ALA A 236
GLU A 211
ASP A 256
ILE A 310
 None
 0.93A 6fbnA-5vf4A:
undetectable		 6fbnA-5vf4A:
25.11