SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vf5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		5 / 12 GLY A  69
GLY A 106
ALA A  71
VAL A 124
LEU A 103
 None
 1.14A 1jg2A-5vf5A:
undetectable		 1jg2A-5vf5A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		4 / 6 ILE A 330
GLY A 395
ALA A 394
HIS A 398
 None
PEG  A 504 (-4.6A)
PEG  A 504 ( 3.8A)
None
 0.98A 1wrqA-5vf5A:
undetectable		 1wrqA-5vf5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		4 / 6 ILE A 330
GLY A 395
ALA A 394
HIS A 398
 None
PEG  A 504 (-4.6A)
PEG  A 504 ( 3.8A)
None
 0.99A 1wrqB-5vf5A:
undetectable		 1wrqB-5vf5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		4 / 7 GLY A 253
GLY A 254
ALA A 331
HIS A 398
 PEG  A 504 (-3.7A)
None
None
None
 0.61A 2ha4B-5vf5A:
undetectable		 2ha4B-5vf5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		4 / 8 GLY A 343
ALA A 243
ASP A 242
ILE A  72
 None
 0.65A 3el0A-5vf5A:
undetectable		 3el0A-5vf5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		5 / 12 PHE A 162
ILE A 169
PHE A 173
TYR A 150
GLY A 142
 None
 1.02A 3hs6B-5vf5A:
undetectable		 3hs6B-5vf5A:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		5 / 12 LEU A 101
PHE A  73
SER A 107
ILE A 109
LEU A 111
 None
 1.16A 3ia4C-5vf5A:
undetectable		 3ia4C-5vf5A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		5 / 12 LEU A 101
PHE A  73
SER A 107
ILE A 109
LEU A 111
 None
 1.20A 3ia4D-5vf5A:
undetectable		 3ia4D-5vf5A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		3 / 3 ASP A  29
SER A  21
ARG A  24
 NA  A 501 ( 4.9A)
None
None
 0.92A 3loqA-5vf5A:
undetectable		 3loqA-5vf5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		5 / 12 GLY A 343
ALA A 243
ASP A 242
VAL A 100
ALA A 246
 None
None
None
None
ACT  A 502 ( 3.9A)
 0.97A 3n3iA-5vf5A:
undetectable		 3n3iA-5vf5A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		3 / 3 ALA A 394
VAL A 393
GLN A 387
 PEG  A 504 ( 3.8A)
None
None
 0.67A 3of4B-5vf5A:
undetectable		 3of4B-5vf5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		5 / 12 ILE A  72
GLY A 341
ALA A 246
PHE A 247
ALA A 230
 None
None
ACT  A 502 ( 3.9A)
None
None
 1.02A 3sudB-5vf5A:
undetectable		 3sudB-5vf5A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		5 / 12 ASN A 261
PHE A 227
PHE A 392
MET A 248
PHE A 220
 ACT  A 502 (-3.3A)
ACT  A 502 (-4.7A)
None
None
None
 1.30A 4c9wA-5vf5A:
undetectable		 4c9wA-5vf5A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		5 / 12 PHE A 162
ILE A 169
PHE A 173
TYR A 150
GLY A 142
 None
 1.02A 4e1gA-5vf5A:
undetectable		 4e1gA-5vf5A:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		5 / 12 PHE A 162
ILE A 169
PHE A 173
GLY A 142
ALA A 141
 None
 1.10A 4e1gB-5vf5A:
undetectable		 4e1gB-5vf5A:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		5 / 12 PHE A 162
ILE A 169
PHE A 173
TYR A 150
GLY A 142
 None
 1.04A 4e1gB-5vf5A:
undetectable		 4e1gB-5vf5A:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		4 / 5 ILE A  72
LEU A 125
ASP A 242
GLU A  70
 None
 1.04A 4nkxB-5vf5A:
undetectable		 4nkxB-5vf5A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		5 / 12 ILE A 109
HIS A  65
ILE A  54
PHE A  30
MET A  62
 None
 1.05A 4rp8C-5vf5A:
undetectable		 4rp8C-5vf5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		3 / 3 LEU A 172
ARG A 171
ARG A 168
 None
 0.90A 4yiaB-5vf5A:
undetectable		 4yiaB-5vf5A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CAD_A_ACTA402_0
(SM80.1 VICILIN)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		4 / 6 PHE A 220
TYR A 259
ASN A 261
LYS A 351
 None
ACT  A 502 (-4.5A)
ACT  A 502 (-3.3A)
ACT  A 502 (-2.7A)
 1.33A 5cadA-5vf5A:
58.4		 5cadA-5vf5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CAD_A_ACTA402_0
(SM80.1 VICILIN)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		4 / 6 PHE A 227
ALA A 246
ASN A 349
ARG A 266
 ACT  A 502 (-4.7A)
ACT  A 502 ( 3.9A)
None
ACT  A 502 (-3.9A)
 1.22A 5cadA-5vf5A:
58.4		 5cadA-5vf5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CAD_A_ACTA402_0
(SM80.1 VICILIN)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		6 / 6 PHE A 227
ALA A 246
TYR A 259
ASN A 261
ARG A 266
LYS A 351
 ACT  A 502 (-4.7A)
ACT  A 502 ( 3.9A)
ACT  A 502 (-4.5A)
ACT  A 502 (-3.3A)
ACT  A 502 (-3.9A)
ACT  A 502 (-2.7A)
 0.01A 5cadA-5vf5A:
58.4		 5cadA-5vf5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		5 / 12 LEU A  33
VAL A  53
PHE A  19
VAL A 270
GLY A 341
 None
 1.40A 5i8fA-5vf5A:
undetectable		 5i8fA-5vf5A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		4 / 6 LEU A 354
TRP A 361
ARG A 362
GLY A 356
 None
 1.00A 5o4yA-5vf5A:
undetectable		 5o4yA-5vf5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		4 / 6 LEU A 354
TRP A 361
ARG A 362
GLY A 356
 None
 0.97A 5o4yF-5vf5A:
undetectable		 5o4yF-5vf5A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YJS_A_SALA603_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		7 / 11 GLY A 341
MET A 248
TYR A 259
ASN A 261
ARG A 266
PHE A 329
LYS A 351
 None
None
ACT  A 502 (-4.5A)
ACT  A 502 (-3.3A)
ACT  A 502 (-3.9A)
None
ACT  A 502 (-2.7A)
 1.19A 5yjsA-5vf5A:
50.7		 5yjsA-5vf5A:
63.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YJS_A_SALA603_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		9 / 11 PHE A 227
MET A 248
TYR A 259
ASN A 261
ARG A 266
VAL A 268
PHE A 329
GLY A 341
LYS A 351
 ACT  A 502 (-4.7A)
None
ACT  A 502 (-4.5A)
ACT  A 502 (-3.3A)
ACT  A 502 (-3.9A)
None
None
None
ACT  A 502 (-2.7A)
 0.31A 5yjsA-5vf5A:
50.7		 5yjsA-5vf5A:
63.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YJS_A_SALA603_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		5 / 11 PHE A 227
TYR A 259
VAL A 339
PHE A 329
LYS A 351
 ACT  A 502 (-4.7A)
ACT  A 502 (-4.5A)
None
None
ACT  A 502 (-2.7A)
 1.49A 5yjsA-5vf5A:
50.7		 5yjsA-5vf5A:
63.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YJS_B_SALB601_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		9 / 9 PHE A 227
MET A 248
TYR A 259
ASN A 261
ARG A 266
VAL A 268
PHE A 329
GLY A 341
LYS A 351
 ACT  A 502 (-4.7A)
None
ACT  A 502 (-4.5A)
ACT  A 502 (-3.3A)
ACT  A 502 (-3.9A)
None
None
None
ACT  A 502 (-2.7A)
 0.34A 5yjsB-5vf5A:
50.8		 5yjsB-5vf5A:
63.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YJS_B_SALB601_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)		 5vf5 SM80.1 VICILIN
(Solanum
melongena) 		5 / 9 PHE A 227
TYR A 259
VAL A 339
PHE A 329
LYS A 351
 ACT  A 502 (-4.7A)
ACT  A 502 (-4.5A)
None
None
ACT  A 502 (-2.7A)
 1.49A 5yjsB-5vf5A:
50.8		 5yjsB-5vf5A:
63.89