SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vfa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 5vfa RESPONSE REGULATOR
(Streptococcus
pneumoniae) 		5 / 12 ILE A 117
PHE A 118
LEU A  22
LEU A  80
MET A  78
 None
 1.18A 1dtlA-5vfaA:
undetectable		 1dtlA-5vfaA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 5vfa RESPONSE REGULATOR
(Streptococcus
pneumoniae) 		6 / 12 ILE A 114
SER A 115
ILE A 117
LEU A  49
VAL A  98
ARG A 161
 None
 1.49A 2nnhA-5vfaA:
undetectable		 2nnhA-5vfaA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 5vfa RESPONSE REGULATOR
(Streptococcus
pneumoniae) 		5 / 11 ALA A  65
ILE A  50
GLY A  35
ILE A  79
ILE A  77
 None
 1.13A 3ebzA-5vfaA:
undetectable		 3ebzA-5vfaA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 5vfa RESPONSE REGULATOR
(Streptococcus
pneumoniae) 		5 / 12 ASP A  58
GLY A  35
ALA A  38
ALA A  42
LEU A   6
 None
 1.02A 3p5nA-5vfaA:
undetectable		 3p5nA-5vfaA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 5vfa RESPONSE REGULATOR
(Streptococcus
pneumoniae) 		5 / 12 ASP A  58
GLY A  35
ALA A  38
ALA A  42
LEU A   6
 None
 1.03A 3p5nB-5vfaA:
undetectable		 3p5nB-5vfaA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 5vfa RESPONSE REGULATOR
(Streptococcus
pneumoniae) 		3 / 3 ILE A 117
VAL A  98
ARG A 161
 None
 0.73A 3p73A-5vfaA:
undetectable		 3p73A-5vfaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5vfa RESPONSE REGULATOR
(Streptococcus
pneumoniae) 		4 / 6 VAL A 105
LYS A 103
ILE A  77
ILE A  50
 None
 0.71A 4tyjA-5vfaA:
undetectable		 4tyjA-5vfaA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 5vfa RESPONSE REGULATOR
(Streptococcus
pneumoniae) 		4 / 7 ALA A  38
ILE A  77
LEU A  68
PHE A  64
 None
 1.12A 4uymB-5vfaA:
undetectable		 4uymB-5vfaA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5vfa RESPONSE REGULATOR
(Streptococcus
pneumoniae) 		5 / 12 GLU A   9
LEU A  56
LYS A 103
ASP A  81
ALA A  65
 None
 1.26A 5kc0A-5vfaA:
undetectable		 5kc0A-5vfaA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5vfa RESPONSE REGULATOR
(Streptococcus
pneumoniae) 		5 / 12 VAL A  32
ASP A  30
LEU A  56
ALA A  38
PHE A  64
 None
 1.31A 5nd4B-5vfaA:
4.3		 5nd4B-5vfaA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWV_A_BEZA202_0
(ARA H 8 ALLERGEN)		 5vfa RESPONSE REGULATOR
(Streptococcus
pneumoniae) 		4 / 4 PHE A  64
ASP A  63
LEU A  68
LYS A  67
 None
 1.13A 6awvA-5vfaA:
undetectable		 6awvA-5vfaA:
undetectable