SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vfr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 9 GLY R 183
ARG R  73
TRP R 184
LEU R  41
GLY R 103
 None
 1.26A 1jb0A-5vfrR:
undetectable		 1jb0A-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5vfr PROTEASOME SUBUNIT
ALPHA TYPE-6
(Homo
sapiens) 		5 / 11 GLY G 158
ILE G 118
ASP G  86
GLY G 135
THR G 126
 None
 1.13A 1jg3A-5vfrG:
undetectable		 1jg3A-5vfrG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5vfr PROTEASOME SUBUNIT
ALPHA TYPE-4
(Homo
sapiens) 		4 / 7 LEU I  99
MET I  72
LEU I  92
GLN I  95
 None
 0.85A 1kt3A-5vfrI:
undetectable		 1kt3A-5vfrI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 5vfr PROTEASOME SUBUNIT
ALPHA TYPE-6
(Homo
sapiens) 		4 / 7 THR G 194
ALA G 198
LEU G 202
SER G 203
 None
 0.78A 1tyrB-5vfrG:
undetectable		 1tyrB-5vfrG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5vfr 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
11
(Homo
sapiens) 		3 / 3 ILE X 217
ASP X 211
PHE X 232
 None
 0.66A 1uwjB-5vfrX:
undetectable		 1uwjB-5vfrX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 5vfr PROTEASOME SUBUNIT
ALPHA TYPE-2
(Homo
sapiens) 		3 / 3 THR H  12
PRO H  15
TYR H   6
 None
 0.77A 2dxrA-5vfrH:
undetectable		 2dxrA-5vfrH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		6 / 11 THR R   1
THR R  21
ALA R  27
LYS R  33
GLY R  47
ALA R  49
 None
 0.66A 2f162-5vfrR:
27.8		 2f162-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
ALA R  27
LYS R  33
GLY R  47
ALA R  49
 None
 0.65A 2f16H-5vfrR:
27.4
2f16I-5vfrR:
25.0		 2f16H-5vfrR:
undetectable
2f16I-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		7 / 10 ALA R  20
THR R  21
ALA R  22
ALA R  27
VAL R  31
LYS R  33
GLY R  48
 None
 0.79A 2f16K-5vfrR:
32.6
2f16L-5vfrR:
23.6		 2f16K-5vfrR:
undetectable
2f16L-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		9 / 10 THR R   1
ALA R  20
THR R  21
ALA R  22
ALA R  27
VAL R  31
LYS R  33
GLY R  47
ALA R  49
 None
 0.62A 2f16K-5vfrR:
32.6
2f16L-5vfrR:
23.6		 2f16K-5vfrR:
undetectable
2f16L-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		6 / 11 THR R   1
THR R  21
ALA R  27
LYS R  33
GLY R  47
ALA R  49
 None
 0.66A 2f16N-5vfrR:
27.8		 2f16N-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
ALA R  27
LYS R  33
GLY R  47
ALA R  49
 None
 0.65A 2f16V-5vfrR:
27.4
2f16W-5vfrR:
25.0		 2f16V-5vfrR:
undetectable
2f16W-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		7 / 10 ALA R  20
THR R  21
ALA R  22
ALA R  27
VAL R  31
LYS R  33
GLY R  48
 None
 0.79A 2f16Y-5vfrR:
24.8
2f16Z-5vfrR:
23.3		 2f16Y-5vfrR:
undetectable
2f16Z-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		9 / 10 THR R   1
ALA R  20
THR R  21
ALA R  22
ALA R  27
VAL R  31
LYS R  33
GLY R  47
ALA R  49
 None
 0.63A 2f16Y-5vfrR:
24.8
2f16Z-5vfrR:
23.3		 2f16Y-5vfrR:
undetectable
2f16Z-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 5vfr PROTEASOME SUBUNIT
ALPHA TYPE-2
(Homo
sapiens) 		5 / 9 VAL H  29
GLY H  78
LEU H 134
LEU H  86
ASP H  82
 None
 1.20A 2j2pB-5vfrH:
undetectable
2j2pC-5vfrH:
undetectable		 2j2pB-5vfrH:
undetectable
2j2pC-5vfrH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 5vfr PROTEASOME SUBUNIT
ALPHA TYPE-2
(Homo
sapiens) 		5 / 12 LEU H 134
ILE H  68
ILE H  72
ILE H 136
VAL H 117
 None
 0.89A 2ygoA-5vfrH:
undetectable		 2ygoA-5vfrH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 5vfr PROTEASOME SUBUNIT
ALPHA TYPE-6
(Homo
sapiens) 		5 / 9 ARG G  95
ASP G 112
GLY G 142
ILE G 141
ILE G 109
 None
 1.18A 3ekyB-5vfrG:
undetectable		 3ekyB-5vfrG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 5vfr 26S PROTEASOME
REGULATORY SUBUNIT
6B
(Homo
sapiens) 		5 / 12 GLY D 169
ILE D 348
LEU D 215
LYS D 212
MET D 214
 None
AGS  D 501 (-4.0A)
None
None
AGS  D 501 (-3.6A)
 1.14A 3fzgA-5vfrD:
undetectable		 3fzgA-5vfrD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 5vfr 26S PROTEASOME
REGULATORY SUBUNIT
6B
(Homo
sapiens) 		4 / 4 ILE D 378
ARG D 338
ILE D 370
THR D 349
 None
 1.14A 3ia4C-5vfrD:
undetectable		 3ia4C-5vfrD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		6 / 12 THR R   1
THR R  21
ALA R  27
LYS R  33
GLY R  47
ALA R  49
 None
 0.69A 3mg02-5vfrR:
27.8
3mg0V-5vfrR:
27.5		 3mg02-5vfrR:
undetectable
3mg0V-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 12 THR R   1
THR R  21
ALA R  27
LYS R  33
GLY R  48
 None
 0.83A 3mg02-5vfrR:
27.8
3mg0V-5vfrR:
27.5		 3mg02-5vfrR:
undetectable
3mg0V-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.69A 3mg0H-5vfrR:
27.5
3mg0I-5vfrR:
24.9		 3mg0H-5vfrR:
undetectable
3mg0I-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		6 / 11 ALA R  20
THR R  21
ALA R  27
VAL R  31
LYS R  33
GLY R  48
 None
 0.77A 3mg0K-5vfrR:
32.8
3mg0L-5vfrR:
23.7		 3mg0K-5vfrR:
undetectable
3mg0L-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		8 / 11 THR R   1
ALA R  20
ALA R  27
VAL R  31
LYS R  33
ALA R  46
GLY R  47
ALA R  49
 None
 0.81A 3mg0K-5vfrR:
32.8
3mg0L-5vfrR:
23.7		 3mg0K-5vfrR:
undetectable
3mg0L-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		9 / 11 THR R   1
ALA R  20
THR R  21
ALA R  27
VAL R  31
LYS R  33
GLY R  47
ALA R  49
SER R 130
 None
 0.77A 3mg0K-5vfrR:
32.8
3mg0L-5vfrR:
23.7		 3mg0K-5vfrR:
undetectable
3mg0L-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		6 / 11 THR R   1
THR R  21
ALA R  27
LYS R  33
GLY R  47
ALA R  49
 None
 0.68A 3mg0N-5vfrR:
27.8		 3mg0N-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
ALA R  27
LYS R  33
GLY R  48
 None
 0.83A 3mg0N-5vfrR:
27.8		 3mg0N-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
ALA R  27
LYS R  33
GLY R  47
ALA R  49
 None
 0.73A 3mg0V-5vfrR:
27.5
3mg0W-5vfrR:
25.0		 3mg0V-5vfrR:
undetectable
3mg0W-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		7 / 12 ALA R  20
ALA R  22
VAL R  31
LYS R  33
ALA R  46
GLY R  47
ALA R  49
 None
 0.74A 3mg0Y-5vfrR:
25.0
3mg0Z-5vfrR:
23.3		 3mg0Y-5vfrR:
undetectable
3mg0Z-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		7 / 12 ALA R  20
THR R  21
ALA R  22
ALA R  27
VAL R  31
LYS R  33
GLY R  48
 None
 0.83A 3mg0Y-5vfrR:
25.0
3mg0Z-5vfrR:
23.3		 3mg0Y-5vfrR:
undetectable
3mg0Z-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		10 / 12 THR R   1
ALA R  20
THR R  21
ALA R  22
ALA R  27
VAL R  31
LYS R  33
GLY R  47
ALA R  49
SER R 130
 None
 0.75A 3mg0Y-5vfrR:
25.0
3mg0Z-5vfrR:
23.3		 3mg0Y-5vfrR:
undetectable
3mg0Z-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 5vfr PROTEASOME SUBUNIT
ALPHA TYPE-4
(Homo
sapiens) 		4 / 8 ASP I 140
PRO I 104
GLN I 109
GLU I 108
 None
 1.15A 3oyaA-5vfrI:
undetectable		 3oyaA-5vfrI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 9 GLY R 183
ARG R  73
TRP R 184
LEU R  41
GLY R 103
 None
 1.27A 3pcqA-5vfrR:
undetectable		 3pcqA-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 5vfr 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
11
(Homo
sapiens) 		4 / 7 ILE X 336
LYS X 372
PHE X 374
GLY X 376
 None
 1.22A 3sj0X-5vfrX:
undetectable		 3sj0X-5vfrX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUZ_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 5vfr 26S PROTEASOME
REGULATORY SUBUNIT
6B
PROTEASOME SUBUNIT
ALPHA TYPE-2
(Homo
sapiens) 		3 / 3 LYS H 165
PRO H  34
LYS D 418
 None
 1.49A 4duzL-5vfrH:
undetectable		 4duzL-5vfrH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV7_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 5vfr 26S PROTEASOME
REGULATORY SUBUNIT
6B
PROTEASOME SUBUNIT
ALPHA TYPE-2
(Homo
sapiens) 		3 / 3 LYS H 165
PRO H  34
LYS D 418
 None
 1.44A 4dv7L-5vfrH:
undetectable		 4dv7L-5vfrH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5vfr PROTEASOME SUBUNIT
ALPHA TYPE-2
(Homo
sapiens) 		5 / 12 LEU H  26
GLU H 120
GLY H 153
LEU H  86
ARG H  89
 None
 1.17A 4hytC-5vfrH:
undetectable		 4hytC-5vfrH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 5vfr PROTEASOME SUBUNIT
ALPHA TYPE-4
(Homo
sapiens) 		3 / 3 TYR I 156
GLN I 146
TRP I 159
 None
 1.17A 4kn2C-5vfrI:
undetectable		 4kn2C-5vfrI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 5vfr PROTEASOME SUBUNIT
ALPHA TYPE-2
PROTEASOME SUBUNIT
ALPHA TYPE-4
(Homo
sapiens) 		5 / 9 LEU H  26
ASP H 150
GLY H 153
ALA H 154
ILE I  79
 None
 1.15A 4njtD-5vfrH:
undetectable		 4njtD-5vfrH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 5vfr PROTEASOME SUBUNIT
ALPHA TYPE-4
(Homo
sapiens) 		5 / 10 LEU I  35
LEU I  44
ALA I  46
LEU I 236
LEU I 197
 None
 1.11A 4p65A-5vfrI:
undetectable
4p65B-5vfrI:
undetectable
4p65F-5vfrI:
undetectable
4p65H-5vfrI:
undetectable		 4p65A-5vfrI:
undetectable
4p65B-5vfrI:
undetectable
4p65F-5vfrI:
undetectable
4p65H-5vfrI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 5vfr PROTEASOME SUBUNIT
ALPHA TYPE-4
(Homo
sapiens) 		5 / 11 LEU I  35
LEU I  44
ALA I  46
LEU I 197
LEU I 236
 None
 1.08A 4p65C-5vfrI:
undetectable
4p65D-5vfrI:
undetectable
4p65J-5vfrI:
undetectable
4p65L-5vfrI:
undetectable		 4p65C-5vfrI:
undetectable
4p65D-5vfrI:
undetectable
4p65J-5vfrI:
undetectable
4p65L-5vfrI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 5vfr 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
11
(Homo
sapiens) 		4 / 7 THR X 422
ALA X 418
LEU X 414
SER X 413
 None
 0.86A 4pwjB-5vfrX:
undetectable		 4pwjB-5vfrX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.63A 4qvlV-5vfrR:
27.7
4qvlb-5vfrR:
28.0		 4qvlV-5vfrR:
undetectable
4qvlb-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		8 / 11 THR R   1
ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  47
GLY R  48
ALA R  49
 None
 0.61A 4qvlK-5vfrR:
32.9
4qvlL-5vfrR:
23.8		 4qvlK-5vfrR:
undetectable
4qvlL-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.63A 4qvlH-5vfrR:
25.9
4qvlN-5vfrR:
28.0		 4qvlH-5vfrR:
undetectable
4qvlN-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		8 / 11 THR R   1
ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  47
GLY R  48
ALA R  49
 None
 0.60A 4qvlY-5vfrR:
19.2
4qvlZ-5vfrR:
23.6		 4qvlY-5vfrR:
undetectable
4qvlZ-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.61A 4qvmV-5vfrR:
27.8
4qvmb-5vfrR:
28.1		 4qvmV-5vfrR:
undetectable
4qvmb-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		8 / 9 THR R   1
ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  47
GLY R  48
ALA R  49
 None
 0.60A 4qvmK-5vfrR:
33.2
4qvmL-5vfrR:
23.8		 4qvmK-5vfrR:
undetectable
4qvmL-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.61A 4qvmH-5vfrR:
26.1
4qvmN-5vfrR:
28.1		 4qvmH-5vfrR:
undetectable
4qvmN-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		8 / 10 THR R   1
ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  47
GLY R  48
ALA R  49
 None
 0.60A 4qvmY-5vfrR:
19.4
4qvmZ-5vfrR:
23.6		 4qvmY-5vfrR:
undetectable
4qvmZ-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		6 / 12 THR R   1
THR R  21
ALA R  27
LYS R  33
GLY R  47
ALA R  49
 None
 0.64A 4qvnV-5vfrR:
27.6
4qvnb-5vfrR:
28.0		 4qvnV-5vfrR:
undetectable
4qvnb-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 9 ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  48
 None
 0.80A 4qvnK-5vfrR:
32.9
4qvnL-5vfrR:
23.7		 4qvnK-5vfrR:
undetectable
4qvnL-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		7 / 9 THR R   1
ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  47
ALA R  49
 None
 0.66A 4qvnK-5vfrR:
32.9
4qvnL-5vfrR:
23.7		 4qvnK-5vfrR:
undetectable
4qvnL-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		6 / 12 THR R   1
THR R  21
ALA R  27
LYS R  33
GLY R  47
ALA R  49
 None
 0.64A 4qvnH-5vfrR:
25.8
4qvnN-5vfrR:
28.0		 4qvnH-5vfrR:
undetectable
4qvnN-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 9 ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  48
 None
 0.82A 4qvnY-5vfrR:
19.2
4qvnZ-5vfrR:
23.5		 4qvnY-5vfrR:
undetectable
4qvnZ-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		7 / 9 THR R   1
ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  47
ALA R  49
 None
 0.66A 4qvnY-5vfrR:
19.2
4qvnZ-5vfrR:
23.5		 4qvnY-5vfrR:
undetectable
4qvnZ-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.60A 4qvpV-5vfrR:
27.6
4qvpb-5vfrR:
28.0		 4qvpV-5vfrR:
undetectable
4qvpb-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 10 ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  48
 None
 0.82A 4qvpK-5vfrR:
33.0
4qvpL-5vfrR:
23.4		 4qvpK-5vfrR:
undetectable
4qvpL-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		8 / 10 THR R   1
ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  47
GLY R  48
ALA R  49
 None
 0.61A 4qvpK-5vfrR:
33.0
4qvpL-5vfrR:
23.4		 4qvpK-5vfrR:
undetectable
4qvpL-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.60A 4qvpH-5vfrR:
25.8
4qvpN-5vfrR:
28.0		 4qvpH-5vfrR:
undetectable
4qvpN-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 10 ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  48
 None
 0.83A 4qvpY-5vfrR:
19.3
4qvpZ-5vfrR:
23.5		 4qvpY-5vfrR:
undetectable
4qvpZ-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		8 / 10 THR R   1
ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  47
GLY R  48
ALA R  49
 None
 0.61A 4qvpY-5vfrR:
19.3
4qvpZ-5vfrR:
23.5		 4qvpY-5vfrR:
undetectable
4qvpZ-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.63A 4qvqV-5vfrR:
27.8
4qvqb-5vfrR:
28.0		 4qvqV-5vfrR:
undetectable
4qvqb-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 9 ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  48
 None
 0.81A 4qvqK-5vfrR:
33.0
4qvqL-5vfrR:
23.8		 4qvqK-5vfrR:
undetectable
4qvqL-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		7 / 9 THR R   1
ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  47
ALA R  49
 None
 0.68A 4qvqK-5vfrR:
33.0
4qvqL-5vfrR:
23.8		 4qvqK-5vfrR:
undetectable
4qvqL-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.63A 4qvqH-5vfrR:
25.9
4qvqN-5vfrR:
28.0		 4qvqH-5vfrR:
undetectable
4qvqN-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 9 ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  48
 None
 0.82A 4qvqY-5vfrR:
19.3
4qvqZ-5vfrR:
23.5		 4qvqY-5vfrR:
undetectable
4qvqZ-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		7 / 9 THR R   1
ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  47
ALA R  49
 None
 0.66A 4qvqY-5vfrR:
19.3
4qvqZ-5vfrR:
23.5		 4qvqY-5vfrR:
undetectable
4qvqZ-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.64A 4qvvH-5vfrR:
26.1		 4qvvH-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 8 THR R   1
THR R  21
LYS R  33
GLY R  47
GLY R  48
 None
 0.61A 4qvvK-5vfrR:
33.3
4qvvL-5vfrR:
23.9		 4qvvK-5vfrR:
undetectable
4qvvL-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.64A 4qvvV-5vfrR:
27.9		 4qvvV-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 8 THR R   1
THR R  21
LYS R  33
GLY R  47
GLY R  48
 None
 0.62A 4qvvY-5vfrR:
25.4
4qvvZ-5vfrR:
23.7		 4qvvY-5vfrR:
undetectable
4qvvZ-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.65A 4qvwV-5vfrR:
27.8
4qvwb-5vfrR:
28.1		 4qvwV-5vfrR:
undetectable
4qvwb-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  48
 None
 0.79A 4qvwK-5vfrR:
33.1
4qvwL-5vfrR:
23.8		 4qvwK-5vfrR:
undetectable
4qvwL-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		7 / 11 THR R   1
ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  47
GLY R  48
 None
 0.63A 4qvwK-5vfrR:
33.1
4qvwL-5vfrR:
23.8		 4qvwK-5vfrR:
undetectable
4qvwL-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.64A 4qvwH-5vfrR:
25.9
4qvwN-5vfrR:
28.1		 4qvwH-5vfrR:
undetectable
4qvwN-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  48
 None
 0.81A 4qvwY-5vfrR:
25.2
4qvwZ-5vfrR:
23.6		 4qvwY-5vfrR:
undetectable
4qvwZ-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		7 / 11 THR R   1
ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  47
GLY R  48
 None
 0.64A 4qvwY-5vfrR:
25.2
4qvwZ-5vfrR:
23.6		 4qvwY-5vfrR:
undetectable
4qvwZ-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.67A 4qvyH-5vfrR:
26.0		 4qvyH-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		7 / 10 ALA R  20
THR R  21
ALA R  22
ALA R  27
VAL R  31
LYS R  33
GLY R  47
 None
 1.06A 4qvyK-5vfrR:
33.2
4qvyL-5vfrR:
23.8		 4qvyK-5vfrR:
undetectable
4qvyL-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		8 / 10 THR R   1
ALA R  20
THR R  21
ALA R  22
ALA R  27
VAL R  31
LYS R  33
GLY R  48
 None
 0.59A 4qvyK-5vfrR:
33.2
4qvyL-5vfrR:
23.8		 4qvyK-5vfrR:
undetectable
4qvyL-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		7 / 10 ALA R  20
THR R  21
ALA R  22
ALA R  27
VAL R  31
LYS R  33
GLY R  47
 None
 1.05A 4qvyY-5vfrR:
25.2
4qvyZ-5vfrR:
23.6		 4qvyY-5vfrR:
undetectable
4qvyZ-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		8 / 10 THR R   1
ALA R  20
THR R  21
ALA R  22
ALA R  27
VAL R  31
LYS R  33
GLY R  48
 None
 0.59A 4qvyY-5vfrR:
25.2
4qvyZ-5vfrR:
23.6		 4qvyY-5vfrR:
undetectable
4qvyZ-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.62A 4qw0V-5vfrR:
27.8
4qw0b-5vfrR:
28.2		 4qw0V-5vfrR:
undetectable
4qw0b-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 7 THR R   1
ALA R  20
THR R  21
ALA R  22
LYS R  33
 None
 0.56A 4qw0K-5vfrR:
33.3		 4qw0K-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.61A 4qw0H-5vfrR:
26.1
4qw0N-5vfrR:
28.2		 4qw0H-5vfrR:
undetectable
4qw0N-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 7 THR R   1
ALA R  20
THR R  21
ALA R  22
LYS R  33
 None
 0.56A 4qw0Y-5vfrR:
25.3		 4qw0Y-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.63A 4qw1V-5vfrR:
27.6
4qw1b-5vfrR:
28.0		 4qw1V-5vfrR:
undetectable
4qw1b-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		8 / 11 THR R   1
ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  47
GLY R  48
ALA R  49
 None
 0.61A 4qw1K-5vfrR:
33.0
4qw1L-5vfrR:
23.8		 4qw1K-5vfrR:
undetectable
4qw1L-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.62A 4qw1H-5vfrR:
25.9
4qw1N-5vfrR:
28.1		 4qw1H-5vfrR:
undetectable
4qw1N-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		8 / 10 THR R   1
ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  47
GLY R  48
ALA R  49
 None
 0.62A 4qw1Y-5vfrR:
19.2
4qw1Z-5vfrR:
23.5		 4qw1Y-5vfrR:
undetectable
4qw1Z-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.63A 4qw3V-5vfrR:
27.9
4qw3b-5vfrR:
28.2		 4qw3V-5vfrR:
undetectable
4qw3b-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		8 / 10 THR R   1
ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  47
GLY R  48
ALA R  49
 None
 0.61A 4qw3K-5vfrR:
33.3
4qw3L-5vfrR:
23.8		 4qw3K-5vfrR:
undetectable
4qw3L-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.63A 4qw3H-5vfrR:
26.1
4qw3N-5vfrR:
28.2		 4qw3H-5vfrR:
undetectable
4qw3N-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		8 / 10 THR R   1
ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  47
GLY R  48
ALA R  49
 None
 0.61A 4qw3Y-5vfrR:
25.4
4qw3Z-5vfrR:
23.6		 4qw3Y-5vfrR:
undetectable
4qw3Z-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.64A 4qwuV-5vfrR:
27.5
4qwub-5vfrR:
27.8		 4qwuV-5vfrR:
undetectable
4qwub-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 9 ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  48
 None
 0.98A 4qwuK-5vfrR:
32.1
4qwuL-5vfrR:
23.5		 4qwuK-5vfrR:
undetectable
4qwuL-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		6 / 9 THR R   1
ALA R  20
ALA R  27
LYS R  33
GLY R  47
GLY R  48
 None
 0.86A 4qwuK-5vfrR:
32.1
4qwuL-5vfrR:
23.5		 4qwuK-5vfrR:
undetectable
4qwuL-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		6 / 9 THR R   1
ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  47
 None
 0.67A 4qwuK-5vfrR:
32.1
4qwuL-5vfrR:
23.5		 4qwuK-5vfrR:
undetectable
4qwuL-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.64A 4qwuH-5vfrR:
25.7
4qwuN-5vfrR:
27.9		 4qwuH-5vfrR:
undetectable
4qwuN-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 9 ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  48
 None
 0.99A 4qwuY-5vfrR:
19.1
4qwuZ-5vfrR:
23.6		 4qwuY-5vfrR:
undetectable
4qwuZ-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		6 / 9 THR R   1
ALA R  20
ALA R  27
LYS R  33
GLY R  47
GLY R  48
 None
 0.84A 4qwuY-5vfrR:
19.1
4qwuZ-5vfrR:
23.6		 4qwuY-5vfrR:
undetectable
4qwuZ-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		6 / 9 THR R   1
ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  47
 None
 0.69A 4qwuY-5vfrR:
19.1
4qwuZ-5vfrR:
23.6		 4qwuY-5vfrR:
undetectable
4qwuZ-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 5vfr PROTEASOME SUBUNIT
ALPHA TYPE-4
(Homo
sapiens) 		5 / 12 ILE I 213
LYS I 180
LEU I  44
LEU I 175
LEU I  35
 None
 1.29A 4qynB-5vfrI:
undetectable		 4qynB-5vfrI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5vfr 26S PROTEASOME
REGULATORY SUBUNIT
6B
(Homo
sapiens) 		4 / 7 VAL D 177
ILE D 261
ALA D 220
ILE D 262
 None
 0.78A 4uxqA-5vfrD:
undetectable		 4uxqA-5vfrD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5vfr PROTEASOME SUBUNIT
ALPHA TYPE-4
(Homo
sapiens) 		5 / 12 CYH I  34
LEU I  35
ALA I  47
LEU I  45
ALA I  77
 None
 1.25A 4x1kA-5vfrI:
undetectable
4x1kB-5vfrI:
undetectable		 4x1kA-5vfrI:
undetectable
4x1kB-5vfrI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 5vfr 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
11
(Homo
sapiens) 		4 / 7 THR X 422
ALA X 418
LEU X 414
SER X 413
 None
 0.90A 5bojB-5vfrX:
undetectable		 5bojB-5vfrX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.62A 5bxnV-5vfrR:
27.6
5bxnb-5vfrR:
28.0		 5bxnV-5vfrR:
undetectable
5bxnb-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		8 / 11 THR R   1
ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  47
GLY R  48
ALA R  49
 None
 0.61A 5bxnK-5vfrR:
32.9
5bxnL-5vfrR:
23.5		 5bxnK-5vfrR:
undetectable
5bxnL-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.62A 5bxnH-5vfrR:
27.5
5bxnN-5vfrR:
28.0		 5bxnH-5vfrR:
undetectable
5bxnN-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.69A 5bxnV-5vfrR:
27.6
5bxnW-5vfrR:
25.1		 5bxnV-5vfrR:
undetectable
5bxnW-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		8 / 11 THR R   1
ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  47
GLY R  48
ALA R  49
 None
 0.61A 5bxnY-5vfrR:
19.2
5bxnZ-5vfrR:
23.5		 5bxnY-5vfrR:
undetectable
5bxnZ-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.62A 5cz7H-5vfrR:
26.0
5cz7N-5vfrR:
28.1		 5cz7H-5vfrR:
undetectable
5cz7N-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.63A 5d0xV-5vfrR:
27.9
5d0xb-5vfrR:
28.1		 5d0xV-5vfrR:
undetectable
5d0xb-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		7 / 9 ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  47
GLY R  48
ALA R  49
 None
 0.52A 5d0xK-5vfrR:
33.2
5d0xL-5vfrR:
23.9		 5d0xK-5vfrR:
undetectable
5d0xL-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.60A 5d0xH-5vfrR:
26.1
5d0xN-5vfrR:
28.1		 5d0xH-5vfrR:
undetectable
5d0xN-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.66A 5d0xV-5vfrR:
27.9		 5d0xV-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		7 / 9 ALA R  20
THR R  21
ALA R  27
LYS R  33
GLY R  47
GLY R  48
ALA R  49
 None
 0.53A 5d0xY-5vfrR:
19.3
5d0xZ-5vfrR:
23.6		 5d0xY-5vfrR:
undetectable
5d0xZ-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 5vfr PROTEASOME SUBUNIT
ALPHA TYPE-4
(Homo
sapiens) 		5 / 9 LEU I  45
GLY I  36
LEU I  44
LEU I 190
ALA I 189
 None
 1.09A 5dqfA-5vfrI:
2.1		 5dqfA-5vfrI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		4 / 8 ILE R  13
LYS R   7
VAL R  14
CYH R 102
 None
 0.95A 5dqyA-5vfrR:
undetectable		 5dqyA-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 5vfr PROTEASOME SUBUNIT
ALPHA TYPE-4
(Homo
sapiens) 		4 / 5 SER I 133
VAL I 132
GLY I  78
ALA I  77
 None
 0.96A 5k50A-5vfrI:
undetectable		 5k50A-5vfrI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 12 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.60A 5l5zV-5vfrR:
27.8
5l5zb-5vfrR:
28.0		 5l5zV-5vfrR:
undetectable
5l5zb-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 12 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.64A 5l5zH-5vfrR:
26.0
5l5zI-5vfrR:
25.2		 5l5zH-5vfrR:
undetectable
5l5zI-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		6 / 9 ALA R  20
THR R  21
ALA R  22
ALA R  27
LYS R  33
GLY R  48
 None
 0.89A 5l5zK-5vfrR:
33.7
5l5zL-5vfrR:
23.6		 5l5zK-5vfrR:
undetectable
5l5zL-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		8 / 9 THR R   1
ALA R  20
THR R  21
ALA R  22
ALA R  27
LYS R  33
GLY R  47
ALA R  49
 None
 0.65A 5l5zK-5vfrR:
33.7
5l5zL-5vfrR:
23.6		 5l5zK-5vfrR:
undetectable
5l5zL-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 12 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.60A 5l5zH-5vfrR:
26.0
5l5zN-5vfrR:
28.0		 5l5zH-5vfrR:
undetectable
5l5zN-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 12 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.66A 5l5zV-5vfrR:
27.8
5l5zW-5vfrR:
25.2		 5l5zV-5vfrR:
undetectable
5l5zW-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		6 / 9 ALA R  20
THR R  21
ALA R  22
ALA R  27
LYS R  33
GLY R  48
 None
 0.89A 5l5zY-5vfrR:
33.6
5l5zZ-5vfrR:
23.7		 5l5zY-5vfrR:
undetectable
5l5zZ-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		8 / 9 THR R   1
ALA R  20
THR R  21
ALA R  22
ALA R  27
LYS R  33
GLY R  47
ALA R  49
 None
 0.65A 5l5zY-5vfrR:
33.6
5l5zZ-5vfrR:
23.7		 5l5zY-5vfrR:
undetectable
5l5zZ-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.60A 5l66V-5vfrR:
27.7
5l66b-5vfrR:
28.1		 5l66V-5vfrR:
undetectable
5l66b-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		6 / 10 THR R   1
ALA R  20
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.58A 5l66K-5vfrR:
33.3
5l66L-5vfrR:
23.9		 5l66K-5vfrR:
undetectable
5l66L-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.60A 5l66H-5vfrR:
26.0
5l66N-5vfrR:
28.1		 5l66H-5vfrR:
undetectable
5l66N-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		6 / 10 THR R   1
ALA R  20
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.58A 5l66Y-5vfrR:
33.3
5l66Z-5vfrR:
23.7		 5l66Y-5vfrR:
undetectable
5l66Z-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 12 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.74A 5lf3b-5vfrR:
27.1		 5lf3b-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 10 THR R   1
ALA R  20
THR R  21
GLY R  47
ALA R  49
 None
 0.62A 5lf3H-5vfrR:
28.3
5lf3I-5vfrR:
25.1		 5lf3H-5vfrR:
undetectable
5lf3I-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		6 / 11 ALA R  20
THR R  21
ALA R  22
LYS R  33
GLY R  47
TYR R 169
 None
 1.12A 5lf3K-5vfrR:
34.4
5lf3L-5vfrR:
24.5		 5lf3K-5vfrR:
undetectable
5lf3L-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		9 / 11 THR R   1
ALA R  20
THR R  21
ALA R  22
LYS R  33
GLY R  47
GLY R  48
ALA R  49
TYR R 169
 None
 0.67A 5lf3K-5vfrR:
34.4
5lf3L-5vfrR:
24.5		 5lf3K-5vfrR:
undetectable
5lf3L-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 12 THR R   1
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.75A 5lf3N-5vfrR:
27.1		 5lf3N-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 10 ALA R  20
LYS R  33
ALA R  46
GLY R  47
ALA R  49
 None
 0.63A 5lf3V-5vfrR:
28.3
5lf3W-5vfrR:
25.1		 5lf3V-5vfrR:
undetectable
5lf3W-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		6 / 10 THR R   1
ALA R  20
THR R  21
LYS R  33
GLY R  47
ALA R  49
 None
 0.66A 5lf3V-5vfrR:
28.3
5lf3W-5vfrR:
25.1		 5lf3V-5vfrR:
undetectable
5lf3W-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		6 / 11 ALA R  20
THR R  21
ALA R  22
LYS R  33
GLY R  47
TYR R 169
 None
 1.11A 5lf3Y-5vfrR:
34.3
5lf3Z-5vfrR:
24.5		 5lf3Y-5vfrR:
undetectable
5lf3Z-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		9 / 11 THR R   1
ALA R  20
THR R  21
ALA R  22
LYS R  33
GLY R  47
GLY R  48
ALA R  49
TYR R 169
 None
 0.65A 5lf3Y-5vfrR:
34.3
5lf3Z-5vfrR:
24.5		 5lf3Y-5vfrR:
undetectable
5lf3Z-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		6 / 12 THR R   1
THR R  21
ALA R  27
LYS R  33
GLY R  47
ALA R  49
 None
 0.76A 5lf7V-5vfrR:
28.3
5lf7b-5vfrR:
27.1		 5lf7V-5vfrR:
undetectable
5lf7b-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
ALA R  20
THR R  21
GLY R  47
ALA R  49
 None
 0.62A 5lf7H-5vfrR:
28.3
5lf7I-5vfrR:
25.1		 5lf7H-5vfrR:
undetectable
5lf7I-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		9 / 11 THR R   1
ALA R  20
THR R  21
ALA R  22
VAL R  31
LYS R  33
GLY R  47
GLY R  48
ALA R  49
 None
 0.76A 5lf7K-5vfrR:
34.3
5lf7L-5vfrR:
24.6		 5lf7K-5vfrR:
undetectable
5lf7L-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		6 / 12 THR R   1
THR R  21
ALA R  27
LYS R  33
GLY R  47
ALA R  49
 None
 0.77A 5lf7H-5vfrR:
28.3
5lf7N-5vfrR:
27.1		 5lf7H-5vfrR:
undetectable
5lf7N-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
ALA R  20
THR R  21
GLY R  47
ALA R  49
 None
 0.61A 5lf7V-5vfrR:
28.3
5lf7W-5vfrR:
25.1		 5lf7V-5vfrR:
undetectable
5lf7W-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		9 / 11 THR R   1
ALA R  20
THR R  21
ALA R  22
VAL R  31
LYS R  33
GLY R  47
GLY R  48
ALA R  49
 None
 0.74A 5lf7Y-5vfrR:
34.2
5lf7Z-5vfrR:
24.5		 5lf7Y-5vfrR:
undetectable
5lf7Z-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 12 GLY R  98
GLY R 129
ASP R 115
ASN R 119
MET R  97
 None
 1.30A 5yniA-5vfrR:
undetectable		 5yniA-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 12 GLY R  98
GLY R 129
ASP R 115
ASN R 119
MET R  97
 None
 1.30A 5ynmA-5vfrR:
undetectable		 5ynmA-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 5vfr PROTEASOME SUBUNIT
ALPHA TYPE-4
(Homo
sapiens) 		4 / 5 GLY I  42
ASP I  41
ARG I 218
GLN I 146
 None
 1.16A 5zrfB-5vfrI:
undetectable		 5zrfB-5vfrI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 5vfr 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
11
26S PROTEASOME
REGULATORY SUBUNIT
6B
(Homo
sapiens) 		5 / 12 GLY X 273
LEU X 275
GLY D 169
ASP D 171
ASP X 240
 None
 0.98A 6gngA-5vfrX:
undetectable		 6gngA-5vfrX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		6 / 12 THR R   1
THR R  21
ALA R  27
LYS R  33
GLY R  47
ALA R  49
 None
 0.67A 6hwdV-5vfrR:
27.6
6hwdb-5vfrR:
27.9		 6hwdV-5vfrR:
undetectable
6hwdb-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 12 THR R   1
ALA R  27
LYS R  33
GLY R  47
ALA R  49
 None
 0.71A 6hwdH-5vfrR:
25.8
6hwdI-5vfrR:
25.0		 6hwdH-5vfrR:
undetectable
6hwdI-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		6 / 11 ALA R  20
THR R  21
ALA R  22
ALA R  27
LYS R  33
GLY R  48
 None
 0.84A 6hwdK-5vfrR:
32.7
6hwdL-5vfrR:
23.7		 6hwdK-5vfrR:
undetectable
6hwdL-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		9 / 11 THR R   1
ALA R  20
THR R  21
ALA R  22
ALA R  27
LYS R  33
GLY R  47
GLY R  48
ALA R  49
 None
 0.66A 6hwdK-5vfrR:
32.7
6hwdL-5vfrR:
23.7		 6hwdK-5vfrR:
undetectable
6hwdL-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		6 / 12 THR R   1
THR R  21
ALA R  27
LYS R  33
GLY R  47
ALA R  49
 None
 0.66A 6hwdH-5vfrR:
25.8
6hwdN-5vfrR:
27.9		 6hwdH-5vfrR:
undetectable
6hwdN-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		5 / 11 THR R   1
ALA R  27
LYS R  33
GLY R  47
ALA R  49
 None
 0.71A 6hwdV-5vfrR:
27.6		 6hwdV-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		6 / 11 ALA R  20
THR R  21
ALA R  22
ALA R  27
LYS R  33
GLY R  48
 None
 0.84A 6hwdY-5vfrR:
19.2
6hwdZ-5vfrR:
23.5		 6hwdY-5vfrR:
undetectable
6hwdZ-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens) 		9 / 11 THR R   1
ALA R  20
THR R  21
ALA R  22
ALA R  27
LYS R  33
GLY R  47
GLY R  48
ALA R  49
 None
 0.67A 6hwdY-5vfrR:
19.2
6hwdZ-5vfrR:
23.5		 6hwdY-5vfrR:
undetectable
6hwdZ-5vfrR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 5vfr 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
11
(Homo
sapiens) 		4 / 7 ALA X 276
THR X 284
ILE X 248
ALA X 247
 None
 1.00A 6ma7A-5vfrX:
undetectable		 6ma7A-5vfrX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5vfr PROTEASOME SUBUNIT
ALPHA TYPE-2
(Homo
sapiens) 		4 / 8 HIS H  63
ARG H  91
HIS H  88
GLU H  66
 None
 1.09A 6mn4D-5vfrH:
undetectable		 6mn4D-5vfrH:
undetectable