SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vft'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 5vft 26S PROTEASOME
REGULATORY SUBUNIT 8
(Homo
sapiens) 		4 / 8 ASP C 119
LEU C 116
GLY C  70
TYR C 121
 None
 0.98A 1rmtC-5vftC:
undetectable		 1rmtC-5vftC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 5vft PROTEASOME SUBUNIT
BETA TYPE-4
(Homo
sapiens) 		3 / 3 ASP T  25
ARG T  41
ASP T 180
 None
 0.89A 1vptA-5vftT:
undetectable		 1vptA-5vftT:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 5vft PROTEASOME SUBUNIT
BETA TYPE-4
(Homo
sapiens) 		5 / 9 LEU T 150
VAL T 169
VAL T  20
ILE T  22
VAL T  21
 None
 1.33A 2l8mA-5vftT:
undetectable		 2l8mA-5vftT:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5vft PROTEASOME SUBUNIT
BETA TYPE-4
(Homo
sapiens) 		5 / 12 LEU T  51
MET T  43
ARG T  41
SER T  54
GLY T  68
 None
 1.05A 2lbdA-5vftT:
undetectable		 2lbdA-5vftT:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5vft PROTEASOME SUBUNIT
BETA TYPE-4
(Homo
sapiens) 		4 / 7 ILE T 189
LEU T 203
PHE T 187
ARG T 171
 None
 1.02A 3ag2N-5vftT:
undetectable
3ag2W-5vftT:
undetectable		 3ag2N-5vftT:
undetectable
3ag2W-5vftT:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5vft PROTEASOME SUBUNIT
BETA TYPE-4
(Homo
sapiens) 		5 / 12 GLY T  28
ILE T  39
GLY T  52
SER T  54
GLY T   8
 None
 1.01A 3hs6B-5vftT:
undetectable		 3hs6B-5vftT:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 5vft 26S PROTEASOME
REGULATORY SUBUNIT 8
(Homo
sapiens) 		4 / 8 ILE C 161
ALA C 204
THR C 207
VAL C 164
 None
 0.73A 3me6B-5vftC:
undetectable		 3me6B-5vftC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 5vft 26S PROTEASOME
REGULATORY SUBUNIT 8
(Homo
sapiens) 		5 / 10 ILE C 292
ILE C 245
VAL C 186
ILE C 165
ILE C 161
 None
 1.15A 3p4wD-5vftC:
2.6		 3p4wD-5vftC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 5vft 26S PROTEASOME
REGULATORY SUBUNIT 8
(Homo
sapiens) 		5 / 10 ILE C 292
ILE C 245
VAL C 186
ILE C 165
ILE C 161
 None
 1.16A 3p4wE-5vftC:
2.6		 3p4wE-5vftC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 5vft PROTEASOME SUBUNIT
BETA TYPE-4
(Homo
sapiens) 		5 / 12 LEU T  92
GLY T 113
GLY T 123
VAL T 192
PRO T  85
 None
 1.01A 4gc9A-5vftT:
undetectable		 4gc9A-5vftT:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 5vft PROTEASOME SUBUNIT
BETA TYPE-4
(Homo
sapiens) 		5 / 12 SER T  54
GLY T  52
ALA T 134
GLY T 123
TYR T 132
 None
 1.25A 4r29A-5vftT:
undetectable		 4r29A-5vftT:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 5vft PROTEASOME SUBUNIT
BETA TYPE-4
(Homo
sapiens) 		5 / 12 SER T  54
GLY T  52
ALA T 134
GLY T 123
TYR T 132
 None
 1.22A 4r29B-5vftT:
undetectable		 4r29B-5vftT:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 5vft PROTEASOME SUBUNIT
BETA TYPE-4
(Homo
sapiens) 		5 / 12 SER T  54
GLY T  52
ALA T 134
GLY T 123
TYR T 132
 None
 1.16A 4r29C-5vftT:
undetectable		 4r29C-5vftT:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5vft PROTEASOME SUBUNIT
BETA TYPE-4
(Homo
sapiens) 		4 / 6 ILE T 189
LEU T 203
PHE T 187
ARG T 171
 None
 1.04A 5b1aN-5vftT:
undetectable
5b1aW-5vftT:
undetectable		 5b1aN-5vftT:
undetectable
5b1aW-5vftT:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 5vft PROTEASOME SUBUNIT
BETA TYPE-4
(Homo
sapiens) 		4 / 6 ARG T 182
ARG T  41
LEU T  27
ASP T  25
 None
 1.16A 5tdzA-5vftT:
undetectable		 5tdzA-5vftT:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5vft 26S PROTEASOME
REGULATORY SUBUNIT 8
(Homo
sapiens) 		3 / 3 ARG C 229
PHE C 283
ARG C 232
 None
 1.11A 5y9yA-5vftC:
undetectable		 5y9yA-5vftC:
undetectable