SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vgb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5vgb CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
ANTI-CRISPR PROTEIN
(ACRIIC1)
(Neisseria
meningitidis;
Neisseria
meningitidis) 		4 / 8 ASN A  88
PHE A  87
ASN A  13
ASP B  44
 SO4  A 203 (-3.9A)
None
None
None
 1.14A 1p6kA-5vgbA:
undetectable		 1p6kA-5vgbA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5vgb CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
ANTI-CRISPR PROTEIN
(ACRIIC1)
(Neisseria
meningitidis;
Neisseria
meningitidis) 		4 / 8 ASN A  88
PHE A  87
ASN A  13
ASP B  44
 SO4  A 203 (-3.9A)
None
None
None
 1.15A 1p6kB-5vgbA:
undetectable		 1p6kB-5vgbA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5vgb CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
ANTI-CRISPR PROTEIN
(ACRIIC1)
(Neisseria
meningitidis;
Neisseria
meningitidis) 		4 / 8 ASN A  88
PHE A  87
ASN A  13
ASP B  44
 SO4  A 203 (-3.9A)
None
None
None
 1.11A 1rs6A-5vgbA:
undetectable		 1rs6A-5vgbA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5vgb CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
ANTI-CRISPR PROTEIN
(ACRIIC1)
(Neisseria
meningitidis;
Neisseria
meningitidis) 		4 / 8 ASN A  88
PHE A  87
ASN A  13
ASP B  44
 SO4  A 203 (-3.9A)
None
None
None
 1.11A 1rs6B-5vgbA:
undetectable		 1rs6B-5vgbA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5vgb CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
ANTI-CRISPR PROTEIN
(ACRIIC1)
(Neisseria
meningitidis;
Neisseria
meningitidis) 		4 / 8 ASN A  88
PHE A  87
ASN A  13
ASP B  44
 SO4  A 203 (-3.9A)
None
None
None
 1.12A 1zzqA-5vgbA:
undetectable		 1zzqA-5vgbA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5vgb CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
ANTI-CRISPR PROTEIN
(ACRIIC1)
(Neisseria
meningitidis;
Neisseria
meningitidis) 		4 / 8 ASN A  88
PHE A  87
ASN A  13
ASP B  44
 SO4  A 203 (-3.9A)
None
None
None
 1.15A 1zzqB-5vgbA:
undetectable		 1zzqB-5vgbA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5vgb CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
ANTI-CRISPR PROTEIN
(ACRIIC1)
(Neisseria
meningitidis;
Neisseria
meningitidis) 		4 / 8 ASN A  88
PHE A  87
ASN A  13
ASP B  44
 SO4  A 203 (-3.9A)
None
None
None
 1.13A 1zzuA-5vgbA:
undetectable		 1zzuA-5vgbA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5vgb CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
ANTI-CRISPR PROTEIN
(ACRIIC1)
(Neisseria
meningitidis;
Neisseria
meningitidis) 		4 / 8 ASN A  88
PHE A  87
ASN A  13
ASP B  44
 SO4  A 203 (-3.9A)
None
None
None
 1.16A 1zzuB-5vgbA:
undetectable		 1zzuB-5vgbA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5vgb CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
ANTI-CRISPR PROTEIN
(ACRIIC1)
(Neisseria
meningitidis;
Neisseria
meningitidis) 		4 / 8 ASN A  88
PHE A  87
ASN A  13
ASP B  44
 SO4  A 203 (-3.9A)
None
None
None
 1.16A 3n66B-5vgbA:
undetectable		 3n66B-5vgbA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5vgb ANTI-CRISPR PROTEIN
(ACRIIC1)
(Neisseria
meningitidis) 		5 / 12 GLY B  15
ILE B  29
GLY B  12
ALA B  21
ALA B  22
 None
 1.02A 3sudC-5vgbB:
undetectable		 3sudC-5vgbB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 5vgb CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
(Neisseria
meningitidis) 		3 / 3 PHE A  87
LYS A 135
SER A 134
 None
 0.69A 3tyeB-5vgbA:
undetectable		 3tyeB-5vgbA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_B_MOAB1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5vgb ANTI-CRISPR PROTEIN
(ACRIIC1)
(Neisseria
meningitidis) 		5 / 10 ASP B  45
ARG B  35
MET B  66
MET B  76
GLY B  75
 GOL  A 201 (-3.6A)
GOL  A 201 ( 4.4A)
None
None
None
 1.33A 4af0B-5vgbB:
undetectable		 4af0B-5vgbB:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5vgb CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
ANTI-CRISPR PROTEIN
(ACRIIC1)
(Neisseria
meningitidis;
Neisseria
meningitidis) 		4 / 7 ASN A  88
PHE A  87
ASN A  13
ASP B  44
 SO4  A 203 (-3.9A)
None
None
None
 1.19A 4kcnB-5vgbA:
undetectable		 4kcnB-5vgbA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 5vgb ANTI-CRISPR PROTEIN
(ACRIIC1)
CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
(Neisseria
meningitidis) 		5 / 12 GLY B   8
ALA B  11
VAL B  31
TYR B  33
ASN A  98
 GOL  B 101 (-3.4A)
GOL  B 101 ( 4.8A)
None
None
None
 1.10A 4pd5A-5vgbB:
undetectable		 4pd5A-5vgbB:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 5vgb ANTI-CRISPR PROTEIN
(ACRIIC1)
(Neisseria
meningitidis) 		5 / 12 GLY B   8
GLU B  27
ALA B  11
VAL B  31
TYR B  33
 GOL  B 101 (-3.4A)
GOL  B 101 (-3.1A)
GOL  B 101 ( 4.8A)
None
None
 1.21A 4pd9A-5vgbB:
undetectable		 4pd9A-5vgbB:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 5vgb ANTI-CRISPR PROTEIN
(ACRIIC1)
CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
(Neisseria
meningitidis) 		5 / 12 GLY B   8
ALA B  11
VAL B  31
TYR B  33
ASN A  98
 GOL  B 101 (-3.4A)
GOL  B 101 ( 4.8A)
None
None
None
 1.15A 4pd9A-5vgbB:
undetectable		 4pd9A-5vgbB:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5vgb CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
ANTI-CRISPR PROTEIN
(ACRIIC1)
(Neisseria
meningitidis;
Neisseria
meningitidis) 		4 / 8 ASN A  88
PHE A  87
ASN A  13
ASP B  44
 SO4  A 203 (-3.9A)
None
None
None
 1.15A 5vunA-5vgbA:
undetectable		 5vunA-5vgbA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5vgb CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
ANTI-CRISPR PROTEIN
(ACRIIC1)
(Neisseria
meningitidis;
Neisseria
meningitidis) 		4 / 8 ASN A  88
PHE A  87
ASN A  13
ASP B  44
 SO4  A 203 (-3.9A)
None
None
None
 1.13A 5vunB-5vgbA:
undetectable		 5vunB-5vgbA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5vgb CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
ANTI-CRISPR PROTEIN
(ACRIIC1)
(Neisseria
meningitidis;
Neisseria
meningitidis) 		4 / 8 ASN A  88
PHE A  87
ASN A  13
ASP B  44
 SO4  A 203 (-3.9A)
None
None
None
 1.13A 5vuoB-5vgbA:
undetectable		 5vuoB-5vgbA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5vgb CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
ANTI-CRISPR PROTEIN
(ACRIIC1)
(Neisseria
meningitidis;
Neisseria
meningitidis) 		4 / 8 ASN A  88
PHE A  87
ASN A  13
ASP B  44
 SO4  A 203 (-3.9A)
None
None
None
 1.15A 6auuB-5vgbA:
undetectable		 6auuB-5vgbA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5vgb CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
(Neisseria
meningitidis) 		5 / 11 SER A  37
VAL A  93
LEU A  92
ALA A  20
PHE A  87
 None
 1.17A 6dryA-5vgbA:
undetectable		 6dryA-5vgbA:
15.30