SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vgj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 5vgj VRC38.01 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 10 TRP H  47
SER H  50
TYR H  58
GLY H  95
TRP H 103
 None
None
MAN  G1563 (-3.9A)
MAN  G1606 (-4.1A)
None
 0.69A 3ls4H-5vgjH:
26.4		 3ls4H-5vgjH:
60.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5vgj VRC38.01 FAB HEAVY
CHAIN
(Homo
sapiens) 		6 / 12 VAL H   2
ALA H  24
MET H  34
ARG H  71
ASN H  76
VAL H  78
 None
 0.64A 3qxtA-5vgjH:
19.3		 3qxtA-5vgjH:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5vgj VRC38.01 FAB HEAVY
CHAIN
(Homo
sapiens) 		6 / 12 VAL H   2
LEU H   4
ALA H  24
MET H  34
ARG H  71
VAL H  78
 None
 0.56A 3qxtB-5vgjH:
19.4		 3qxtB-5vgjH:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5vgj VRC38.01 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 VAL H   2
ALA H  24
MET H  34
ARG H  71
VAL H  78
 None
 0.69A 3qxvD-5vgjH:
19.1		 3qxvD-5vgjH:
36.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 5vgj 1FD6-V1V2-WITO
(Human
immunodeficiency
virus
1) 		5 / 12 LEU G 193
GLY G 240
LEU G 241
GLU G 239
PHE G 159
 None
NAG  G1600 (-3.9A)
None
None
None
 1.34A 3tbgA-5vgjG:
undetectable		 3tbgA-5vgjG:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 5vgj 1FD6-V1V2-WITO
(Human
immunodeficiency
virus
1) 		5 / 12 LEU G 193
GLY G 240
LEU G 241
GLU G 239
PHE G 159
 None
NAG  G1600 (-3.9A)
None
None
None
 1.34A 3tbgC-5vgjG:
undetectable		 3tbgC-5vgjG:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 5vgj VRC38.01 FAB HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 THR H  82
GLY H  16
VAL H  12
PRO H  14
 None
 1.02A 4grkA-5vgjH:
undetectable		 4grkA-5vgjH:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5vgj VRC38.01 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 10 PHE H 122
GLY H 118
THR H 205
VAL H 198
VAL H 207
 None
 1.21A 4jx1B-5vgjH:
undetectable		 4jx1B-5vgjH:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 5vgj 1FD6-V1V2-WITO
(Human
immunodeficiency
virus
1) 		4 / 7 LEU G 129
THR G 161
THR G 162
LEU G 193
 None
 1.13A 5jq7B-5vgjG:
undetectable		 5jq7B-5vgjG:
20.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 5vgj VRC38.01 FAB HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 SER H 112
ALA H 114
PHE H 146
LEU H 170
 None
 0.28A 5mthA-5vgjH:
25.4		 5mthA-5vgjH:
51.05