SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vgm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 5vgm DIHYDROOROTASE
(Vibrio
cholerae) 		5 / 10 ALA A 275
GLU A 276
LEU A 200
ARG A 332
ILE A 194
 None
 1.48A 1a52A-5vgmA:
undetectable		 1a52A-5vgmA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 5vgm DIHYDROOROTASE
(Vibrio
cholerae) 		4 / 5 HIS A  13
HIS A 135
HIS A 173
ASP A 246
 ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 402 (-2.7A)
 0.61A 1e9yB-5vgmA:
18.2		 1e9yB-5vgmA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 5vgm DIHYDROOROTASE
(Vibrio
cholerae) 		5 / 6 HIS A  13
HIS A  15
HIS A 135
HIS A 173
ASP A 246
 ZN  A 402 (-3.3A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 402 (-2.7A)
 0.63A 1fweC-5vgmA:
6.1		 1fweC-5vgmA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 5vgm DIHYDROOROTASE
(Vibrio
cholerae) 		4 / 7 TYR A  32
VAL A  14
GLU A 272
LEU A 287
 None
 1.01A 1j96B-5vgmA:
6.7		 1j96B-5vgmA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 5vgm DIHYDROOROTASE
(Vibrio
cholerae) 		3 / 3 ASN A 189
PHE A 182
VAL A 161
 None
 0.67A 1kijA-5vgmA:
undetectable		 1kijA-5vgmA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 5vgm DIHYDROOROTASE
(Vibrio
cholerae) 		5 / 11 VAL A  21
LEU A  22
GLY A  19
PRO A  44
THR A  42
 None
None
None
None
ACT  A 403 (-4.4A)
 1.23A 3bjwB-5vgmA:
undetectable		 3bjwB-5vgmA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 5vgm DIHYDROOROTASE
(Vibrio
cholerae) 		5 / 11 VAL A  21
LEU A  22
GLY A  19
PRO A  44
THR A  42
 None
None
None
None
ACT  A 403 (-4.4A)
 1.28A 3bjwE-5vgmA:
undetectable		 3bjwE-5vgmA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 5vgm DIHYDROOROTASE
(Vibrio
cholerae) 		5 / 12 VAL A  21
LEU A  22
GLY A  19
PRO A  44
THR A  42
 None
None
None
None
ACT  A 403 (-4.4A)
 1.25A 3bjwF-5vgmA:
undetectable		 3bjwF-5vgmA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 5vgm DIHYDROOROTASE
(Vibrio
cholerae) 		5 / 11 VAL A  21
LEU A  22
GLY A  19
PRO A  44
THR A  42
 None
None
None
None
ACT  A 403 (-4.4A)
 1.21A 3bjwH-5vgmA:
undetectable		 3bjwH-5vgmA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5vgm DIHYDROOROTASE
(Vibrio
cholerae) 		5 / 12 ILE A  59
ALA A  62
ASN A  33
LEU A  22
ALA A  23
 None
 0.99A 3dzyA-5vgmA:
undetectable		 3dzyA-5vgmA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 5vgm DIHYDROOROTASE
(Vibrio
cholerae) 		3 / 3 GLU A 172
HIS A  13
THR A 193
 None
ZN  A 402 (-3.3A)
None
 0.89A 3hkuA-5vgmA:
undetectable		 3hkuA-5vgmA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 5vgm DIHYDROOROTASE
(Vibrio
cholerae) 		3 / 3 ASP A  11
ASN A  33
SER A 247
 None
 0.96A 3lslA-5vgmA:
undetectable
3lslD-5vgmA:
undetectable		 3lslA-5vgmA:
20.56
3lslD-5vgmA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5vgm DIHYDROOROTASE
(Vibrio
cholerae) 		4 / 6 ALA A 269
THR A 266
ALA A 196
THR A 245
 None
 1.08A 3mdrB-5vgmA:
undetectable		 3mdrB-5vgmA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 5vgm DIHYDROOROTASE
(Vibrio
cholerae) 		5 / 12 ASP A 246
HIS A  13
HIS A  15
ALA A 262
CYH A 217
 ZN  A 402 (-2.7A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.3A)
CSX  A 261 ( 3.6A)
None
 1.07A 3r2jC-5vgmA:
2.1		 3r2jC-5vgmA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 5vgm DIHYDROOROTASE
(Vibrio
cholerae) 		5 / 11 ILE A  29
LEU A 271
ASP A  10
GLY A  34
PHE A  68
 None
 1.39A 4foxF-5vgmA:
undetectable		 4foxF-5vgmA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 5vgm DIHYDROOROTASE
(Vibrio
cholerae) 		4 / 5 HIS A  13
HIS A 135
HIS A 173
ASP A 246
 ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 402 (-2.7A)
 0.59A 4h9mA-5vgmA:
4.4		 4h9mA-5vgmA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5vgm DIHYDROOROTASE
(Vibrio
cholerae) 		5 / 12 ILE A  59
ALA A  62
LEU A  22
ALA A  23
VAL A  14
 None
 0.66A 4k6iA-5vgmA:
undetectable		 4k6iA-5vgmA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_B_DM5B601_1
(SERUM ALBUMIN)		 5vgm DIHYDROOROTASE
(Vibrio
cholerae) 		5 / 9 LEU A  74
VAL A  46
PRO A  45
GLU A  84
ILE A  85
 None
 1.48A 4lb2B-5vgmA:
0.3		 4lb2B-5vgmA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 5vgm DIHYDROOROTASE
(Vibrio
cholerae) 		5 / 6 HIS A  13
HIS A  15
HIS A 135
HIS A 173
ASP A 246
 ZN  A 402 (-3.3A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 402 (-2.7A)
 0.47A 4ubpC-5vgmA:
19.0		 4ubpC-5vgmA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EU8_B_010B6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 5vgm DIHYDROOROTASE
(Vibrio
cholerae) 		4 / 5 LEU A 218
HIS A 173
THR A 175
CYH A 217
 None
ZN  A 401 (-3.3A)
None
None
 1.49A 5eu8A-5vgmA:
undetectable		 5eu8A-5vgmA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5vgm DIHYDROOROTASE
(Vibrio
cholerae) 		4 / 4 ASP A 246
HIS A 173
HIS A 135
HIS A  15
 ZN  A 402 (-2.7A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
 1.47A 5ncdD-5vgmA:
3.5		 5ncdD-5vgmA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5vgm DIHYDROOROTASE
(Vibrio
cholerae) 		5 / 8 ASP A 246
HIS A 173
HIS A 135
PRO A 219
HIS A  15
 ZN  A 402 (-2.7A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
None
ZN  A 402 (-3.3A)
 1.40A 5nekB-5vgmA:
3.0		 5nekB-5vgmA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 5vgm DIHYDROOROTASE
(Vibrio
cholerae) 		3 / 3 MET A  72
GLU A  57
ARG A  56
 None
 0.93A 5tjyA-5vgmA:
2.5		 5tjyA-5vgmA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 5vgm DIHYDROOROTASE
(Vibrio
cholerae) 		3 / 3 MET A  72
GLU A  57
ARG A  56
 None
 0.95A 5tjzA-5vgmA:
2.4		 5tjzA-5vgmA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 5vgm DIHYDROOROTASE
(Vibrio
cholerae) 		5 / 11 ILE A  29
LEU A 271
ASP A  10
GLY A  34
PHE A  68
 None
 1.31A 6r2eG-5vgmA:
undetectable		 6r2eG-5vgmA:
22.05