SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vgr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 5vgr ATLASTIN-3
(Homo
sapiens) 		4 / 7 ALA A 350
TYR A 324
SER A 358
ALA A 356
 None
 0.90A 1k5qA-5vgrA:
undetectable
1k5qB-5vgrA:
undetectable		 1k5qA-5vgrA:
17.41
1k5qB-5vgrA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5vgr ATLASTIN-3
(Homo
sapiens) 		5 / 12 THR A 261
GLY A 228
GLY A 227
GLY A 224
ASP A 233
 None
 1.19A 1wg8A-5vgrA:
undetectable		 1wg8A-5vgrA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5vgr ATLASTIN-3
(Homo
sapiens) 		5 / 12 THR A 261
GLY A 228
GLY A 227
GLY A 224
ASP A 233
 None
 1.16A 1wg8B-5vgrA:
undetectable		 1wg8B-5vgrA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 5vgr ATLASTIN-3
(Homo
sapiens) 		3 / 3 PHE A 231
VAL A 212
TRP A 215
 None
 0.70A 2cc8A-5vgrA:
undetectable		 2cc8A-5vgrA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 5vgr ATLASTIN-3
(Homo
sapiens) 		3 / 3 PHE A 231
VAL A 212
TRP A 215
 None
 0.69A 2ccbA-5vgrA:
undetectable		 2ccbA-5vgrA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 5vgr ATLASTIN-3
(Homo
sapiens) 		5 / 9 ALA A 354
SER A 410
PHE A 409
GLY A 405
ALA A 348
 None
 1.49A 2vh3A-5vgrA:
undetectable		 2vh3A-5vgrA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 5vgr ATLASTIN-3
(Homo
sapiens) 		3 / 3 PHE A 231
VAL A 212
TRP A 215
 None
 0.69A 2vx9A-5vgrA:
undetectable		 2vx9A-5vgrA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 5vgr ATLASTIN-3
(Homo
sapiens) 		3 / 3 TYR A 192
TYR A 332
ILE A 331
 None
 0.75A 3eteA-5vgrA:
undetectable
3eteB-5vgrA:
1.9		 3eteA-5vgrA:
19.85
3eteB-5vgrA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 5vgr ATLASTIN-3
(Homo
sapiens) 		5 / 10 LEU A  31
ASP A  42
ALA A  45
ILE A  49
VAL A  27
 None
 1.00A 3ogqA-5vgrA:
undetectable		 3ogqA-5vgrA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5vgr ATLASTIN-3
(Homo
sapiens) 		4 / 7 ASP A 233
ILE A 253
VAL A 249
ARG A 250
 None
 1.10A 3p6hA-5vgrA:
undetectable		 3p6hA-5vgrA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 5vgr ATLASTIN-3
(Homo
sapiens) 		4 / 8 THR A 143
GLY A 118
ILE A 119
VAL A  30
 None
 0.97A 4e1vE-5vgrA:
2.7		 4e1vE-5vgrA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5vgr ATLASTIN-3
(Homo
sapiens) 		4 / 7 ILE A 178
GLY A 228
PHE A 231
TYR A 299
 None
 0.77A 4iqqB-5vgrA:
undetectable		 4iqqB-5vgrA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5vgr ATLASTIN-3
(Homo
sapiens) 		4 / 7 ILE A 178
GLY A 228
PHE A 231
TYR A 299
 None
 0.75A 4iqqC-5vgrA:
undetectable		 4iqqC-5vgrA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5vgr ATLASTIN-3
(Homo
sapiens) 		4 / 6 SER A 168
GLN A 206
VAL A 316
THR A 317
 None
 1.11A 4lnxA-5vgrA:
undetectable		 4lnxA-5vgrA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 5vgr ATLASTIN-3
(Homo
sapiens) 		4 / 6 ILE A 121
SER A 167
PHE A 325
LEU A 321
 None
 0.89A 4m51A-5vgrA:
undetectable		 4m51A-5vgrA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5vgr ATLASTIN-3
(Homo
sapiens) 		4 / 6 PHE A 210
ILE A 178
ARG A 235
VAL A 249
 None
 1.23A 4mk4B-5vgrA:
undetectable		 4mk4B-5vgrA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 5vgr ATLASTIN-3
(Homo
sapiens) 		3 / 3 GLY A 110
GLY A 111
GLN A 120
 None
 0.47A 5imsA-5vgrA:
2.4		 5imsA-5vgrA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5vgr ATLASTIN-3
(Homo
sapiens) 		4 / 7 ILE A 178
GLY A 228
PHE A 231
TYR A 299
 None
 0.82A 5nooB-5vgrA:
undetectable		 5nooB-5vgrA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 5vgr ATLASTIN-3
(Homo
sapiens) 		4 / 8 ASN A 173
VAL A  65
ILE A 171
ARG A 213
 None
None
None
GDP  A 501 (-3.7A)
 0.79A 6cb4A-5vgrA:
undetectable		 6cb4A-5vgrA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBP_B_ADNB404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5vgr ATLASTIN-3
(Homo
sapiens) 		5 / 12 ASP A  78
ILE A  76
ILE A 297
PRO A 268
PHE A  79
 None
None
None
GDP  A 501 (-4.0A)
None
 1.41A 6fbpA-5vgrA:
undetectable
6fbpB-5vgrA:
undetectable		 6fbpA-5vgrA:
13.28
6fbpB-5vgrA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5vgr ATLASTIN-3
(Homo
sapiens) 		4 / 7 HIS A 397
THR A 401
HIS A 387
ASP A 396
 None
 1.33A 6mn4E-5vgrA:
undetectable		 6mn4E-5vgrA:
20.56