SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vgz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5vgz 26S PROTEASOME
REGULATORY SUBUNIT
6B
26S PROTEASOME
REGULATORY SUBUNIT 8
(Homo
sapiens) 		5 / 11 SER D 117
LEU C  59
ILE D 115
ALA D 138
LEU C  66
 None
 1.12A 1eqgB-5vgzD:
undetectable		 1eqgB-5vgzD:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5vgz 26S PROTEASOME
REGULATORY SUBUNIT 4
26S PROTEASOME
REGULATORY SUBUNIT 8
(Homo
sapiens) 		3 / 3 THR B 111
GLU C  92
HIS B 131
 None
 0.78A 1xwfA-5vgzB:
undetectable		 1xwfA-5vgzB:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5vgz 26S PROTEASOME
REGULATORY SUBUNIT 4
26S PROTEASOME
REGULATORY SUBUNIT 8
(Homo
sapiens) 		3 / 3 THR B 111
GLU C  92
HIS B 131
 None
 0.77A 1xwfB-5vgzB:
3.7		 1xwfB-5vgzB:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5vgz 26S PROTEASOME
REGULATORY SUBUNIT 4
26S PROTEASOME
REGULATORY SUBUNIT 8
(Homo
sapiens) 		3 / 3 THR B 111
GLU C  92
HIS B 131
 None
 0.73A 1xwfC-5vgzB:
2.9		 1xwfC-5vgzB:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5vgz 26S PROTEASOME
REGULATORY SUBUNIT 4
26S PROTEASOME
REGULATORY SUBUNIT 8
(Homo
sapiens) 		3 / 3 THR B 111
GLU C  92
HIS B 157
 None
 0.92A 1xwfC-5vgzB:
2.9		 1xwfC-5vgzB:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5vgz 26S PROTEASOME
REGULATORY SUBUNIT 4
26S PROTEASOME
REGULATORY SUBUNIT 8
(Homo
sapiens) 		3 / 3 THR B 111
GLU C  92
HIS B 131
 None
 0.79A 1xwfD-5vgzB:
undetectable		 1xwfD-5vgzB:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5vgz 26S PROTEASOME
REGULATORY SUBUNIT 7
26S PROTEASOME
REGULATORY SUBUNIT 4
(Homo
sapiens;
Homo
sapiens) 		4 / 5 PRO A 152
ILE A 149
GLY A 141
TYR B 132
 None
 1.12A 2jkjD-5vgzA:
undetectable		 2jkjD-5vgzA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5vgz 26S PROTEASOME
REGULATORY SUBUNIT 7
26S PROTEASOME
REGULATORY SUBUNIT 4
(Homo
sapiens;
Homo
sapiens) 		4 / 5 PRO A 152
ILE A 149
GLY A 141
TYR B 132
 None
 1.12A 2jkjF-5vgzA:
undetectable		 2jkjF-5vgzA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 5vgz 26S PROTEASOME
REGULATORY SUBUNIT 8
(Homo
sapiens) 		5 / 11 VAL C  85
ILE C 105
ILE C 126
VAL C  77
VAL C  87
 None
 1.07A 2nnpB-5vgzC:
undetectable		 2nnpB-5vgzC:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5vgz 26S PROTEASOME
REGULATORY SUBUNIT 4
(Homo
sapiens) 		4 / 4 SER B 129
GLY B 128
HIS B 120
ASP B 117
 None
 1.31A 2oxtC-5vgzB:
undetectable		 2oxtC-5vgzB:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 5vgz 26S PROTEASOME
REGULATORY SUBUNIT
10B
(Homo
sapiens) 		5 / 10 THR E  96
GLY E  58
PHE E  69
GLU E  59
ILE E 107
 None
 1.32A 3kvrA-5vgzE:
undetectable		 3kvrA-5vgzE:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 5vgz 26S PROTEASOME
REGULATORY SUBUNIT
10B
(Homo
sapiens) 		5 / 10 THR E  96
GLY E  58
PHE E  69
GLU E  59
ILE E 107
 None
 1.29A 3kvrB-5vgzE:
undetectable		 3kvrB-5vgzE:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5vgz 26S PROTEASOME
REGULATORY SUBUNIT 4
(Homo
sapiens) 		4 / 5 PRO B 106
ASN B 153
ILE B 160
VAL B 133
 None
 1.30A 4hytA-5vgzB:
3.4		 4hytA-5vgzB:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5vgz 26S PROTEASOME
REGULATORY SUBUNIT 8
(Homo
sapiens) 		4 / 5 GLY C  70
TYR C 121
TYR C  72
GLY C  74
 None
 0.94A 5ayfA-5vgzC:
undetectable		 5ayfA-5vgzC:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 5vgz 26S PROTEASOME
REGULATORY SUBUNIT
10B
26S PROTEASOME
REGULATORY SUBUNIT
6A
(Homo
sapiens) 		5 / 9 GLU E 114
ILE F  94
PRO F 147
ALA F 122
LEU F  96
 None
 1.13A 5mvmA-5vgzE:
undetectable
5mvmE-5vgzE:
undetectable		 5mvmA-5vgzE:
18.69
5mvmE-5vgzE:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 5vgz 26S PROTEASOME
REGULATORY SUBUNIT 7
26S PROTEASOME
REGULATORY SUBUNIT 4
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU A 153
ILE B 115
GLU B 114
ASP B 118
 None
 1.05A 5n5dA-5vgzA:
undetectable		 5n5dA-5vgzA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 5vgz 26S PROTEASOME
REGULATORY SUBUNIT 7
26S PROTEASOME
REGULATORY SUBUNIT 4
(Homo
sapiens;
Homo
sapiens) 		4 / 7 GLY B 161
ILE B 135
GLN A  85
ASP A  79
 None
 1.00A 5vlmC-5vgzB:
undetectable		 5vlmC-5vgzB:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 5vgz 26S PROTEASOME
REGULATORY SUBUNIT 7
26S PROTEASOME
REGULATORY SUBUNIT 4
(Homo
sapiens;
Homo
sapiens) 		4 / 8 GLY B 161
ILE B 135
GLN A  85
ASP A  79
 None
 1.06A 5vlmD-5vgzB:
undetectable		 5vlmD-5vgzB:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5vgz 26S PROTEASOME
REGULATORY SUBUNIT 4
26S PROTEASOME
REGULATORY SUBUNIT 8
(Homo
sapiens;
Homo
sapiens) 		3 / 3 SER B 108
HIS B 154
TYR C 121
 None
 0.88A 5y2tA-5vgzB:
undetectable		 5y2tA-5vgzB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5vgz 26S PROTEASOME
REGULATORY SUBUNIT
10B
26S PROTEASOME
REGULATORY SUBUNIT
6A
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LYS F  79
ASN F  76
SER E  43
 None
 1.17A 5yw0A-5vgzF:
undetectable		 5yw0A-5vgzF:
17.68