SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vh6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 5vh6 ELONGATION FACTOR G
(Bacillus
subtilis) 		5 / 12 THR A  26
GLY A 259
SER A 260
ASP A 177
ILE A 162
 None
 1.14A 2b25B-5vh6A:
undetectable		 2b25B-5vh6A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 5vh6 ELONGATION FACTOR G
(Bacillus
subtilis) 		5 / 9 THR A  34
LEU A 271
VAL A 270
ILE A  15
VAL A 103
 None
 1.15A 2l8mA-5vh6A:
undetectable		 2l8mA-5vh6A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5vh6 ELONGATION FACTOR G
(Bacillus
subtilis) 		5 / 11 LEU A  96
LEU A  99
LEU A 278
PRO A 279
VAL A 251
 None
 1.35A 2po5B-5vh6A:
3.4		 2po5B-5vh6A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 5vh6 ELONGATION FACTOR G
(Bacillus
subtilis) 		5 / 12 LEU A  96
LEU A  99
LEU A 278
PRO A 279
VAL A 251
 None
 1.35A 2qd4B-5vh6A:
3.7		 2qd4B-5vh6A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 5vh6 ELONGATION FACTOR G
(Bacillus
subtilis) 		3 / 3 GLY A 111
TYR A 146
SER A 110
 None
 0.77A 2xatA-5vh6A:
undetectable		 2xatA-5vh6A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5vh6 ELONGATION FACTOR G
(Bacillus
subtilis) 		5 / 12 PHE A 262
GLY A  22
PHE A 133
ILE A  15
ARG A  29
 None
 1.14A 3iv6B-5vh6A:
2.7		 3iv6B-5vh6A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 5vh6 ELONGATION FACTOR G
(Bacillus
subtilis) 		5 / 12 THR A 384
THR A 325
ALA A 375
ALA A  66
SER A  65
 None
 1.05A 3mg02-5vh6A:
undetectable
3mg0V-5vh6A:
undetectable		 3mg02-5vh6A:
19.04
3mg0V-5vh6A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 5vh6 ELONGATION FACTOR G
(Bacillus
subtilis) 		4 / 6 LEU A  96
LEU A  99
ILE A  13
THR A  82
 None
 0.84A 4do3B-5vh6A:
undetectable		 4do3B-5vh6A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5vh6 ELONGATION FACTOR G
(Bacillus
subtilis) 		4 / 5 TYR A 339
ARG A 350
GLU A 349
VAL A 315
 None
 1.26A 4nkvB-5vh6A:
undetectable		 4nkvB-5vh6A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vh6 ELONGATION FACTOR G
(Bacillus
subtilis) 		5 / 12 SER A  65
THR A 384
THR A 325
ALA A 375
ALA A  66
 None
 1.07A 4qvnV-5vh6A:
undetectable
4qvnb-5vh6A:
undetectable		 4qvnV-5vh6A:
19.71
4qvnb-5vh6A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vh6 ELONGATION FACTOR G
(Bacillus
subtilis) 		5 / 12 SER A  65
THR A 384
THR A 325
ALA A 375
ALA A  66
 None
 1.06A 4qvnH-5vh6A:
undetectable
4qvnN-5vh6A:
undetectable		 4qvnH-5vh6A:
19.71
4qvnN-5vh6A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5vh6 ELONGATION FACTOR G
(Bacillus
subtilis) 		5 / 12 VAL A  77
ILE A  13
GLY A 101
VAL A 284
LEU A 249
 None
 1.13A 4y8wB-5vh6A:
undetectable		 4y8wB-5vh6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 5vh6 ELONGATION FACTOR G
(Bacillus
subtilis) 		4 / 5 TYR A 186
PHE A 144
LEU A 257
PRO A 165
 CL  A 501 (-4.7A)
None
None
None
 1.28A 5csyB-5vh6A:
undetectable		 5csyB-5vh6A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5vh6 ELONGATION FACTOR G
(Bacillus
subtilis) 		3 / 3 THR A  68
MET A 357
HIS A 358
 None
 0.94A 5uunA-5vh6A:
undetectable		 5uunA-5vh6A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5vh6 ELONGATION FACTOR G
(Bacillus
subtilis) 		4 / 6 SER A 338
ARG A 348
GLU A 391
TYR A 339
 None
 1.37A 5x7pA-5vh6A:
undetectable		 5x7pA-5vh6A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 5vh6 ELONGATION FACTOR G
(Bacillus
subtilis) 		4 / 8 LEU A 388
VAL A 368
LEU A 334
ILE A 354
 None
 0.84A 6cb4A-5vh6A:
undetectable		 6cb4A-5vh6A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 5vh6 ELONGATION FACTOR G
(Bacillus
subtilis) 		5 / 12 SER A  65
THR A 384
THR A 325
ALA A 375
ALA A  66
 None
 1.10A 6hwdV-5vh6A:
undetectable
6hwdb-5vh6A:
undetectable		 6hwdV-5vh6A:
13.52
6hwdb-5vh6A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 5vh6 ELONGATION FACTOR G
(Bacillus
subtilis) 		5 / 12 SER A  65
THR A 384
THR A 325
ALA A 375
ALA A  66
 None
 1.10A 6hwdH-5vh6A:
undetectable
6hwdN-5vh6A:
undetectable		 6hwdH-5vh6A:
13.52
6hwdN-5vh6A:
10.20