SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vha'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		4 / 7 SER A 291
THR A 292
ASN A 290
CYH A 286
 None
 0.97A 1dssG-5vhaA:
2.8		 1dssG-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		4 / 8 SER A 291
THR A 292
ASN A 290
CYH A 286
 None
 0.96A 1dssR-5vhaA:
undetectable		 1dssR-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		4 / 6 SER A 345
THR A 314
THR A 264
ILE A 333
 None
 0.90A 1gtnD-5vhaA:
undetectable
1gtnE-5vhaA:
undetectable		 1gtnD-5vhaA:
undetectable
1gtnE-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		5 / 9 VAL A 364
THR A 314
THR A 264
ILE A 333
SER A 345
 None
 0.91A 1gtnL-5vhaA:
undetectable
1gtnM-5vhaA:
undetectable		 1gtnL-5vhaA:
undetectable
1gtnM-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCB_P_DHIP3_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-L-GLN-D-PHE
-L-HIS-D-PRO-OH)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		4 / 5 TYR A 483
TYR A 567
GLU A 488
TYR A 614
 None
 1.38A 1mcbA-5vhaA:
0.0
1mcbB-5vhaA:
0.0
1mcbP-5vhaA:
undetectable		 1mcbA-5vhaA:
undetectable
1mcbB-5vhaA:
undetectable
1mcbP-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		3 / 3 VAL A 869
ALA A 870
HIS A 872
 None
 0.70A 1q23G-5vhaA:
undetectable		 1q23G-5vhaA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		5 / 12 ALA A 271
THR A 558
SER A 559
ILE A 560
LEU A 526
 None
 1.13A 1rg7A-5vhaA:
undetectable		 1rg7A-5vhaA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		3 / 3 PRO A 543
ASP A 564
ASP A 490
 None
 0.74A 1sqfA-5vhaA:
2.4		 1sqfA-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		5 / 11 GLY A 705
VAL A 700
GLU A 640
ILE A 708
HIS A 891
 None
 1.08A 1vhwA-5vhaA:
undetectable
1vhwD-5vhaA:
undetectable		 1vhwA-5vhaA:
14.23
1vhwD-5vhaA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		5 / 11 GLY A 705
VAL A 700
GLU A 640
ILE A 708
HIS A 891
 None
 1.08A 1vhwC-5vhaA:
undetectable
1vhwE-5vhaA:
undetectable		 1vhwC-5vhaA:
14.23
1vhwE-5vhaA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		5 / 11 HIS A 891
GLY A 705
VAL A 700
GLU A 640
ILE A 708
 None
 1.08A 1vhwC-5vhaA:
undetectable
1vhwE-5vhaA:
undetectable		 1vhwC-5vhaA:
14.23
1vhwE-5vhaA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		3 / 3 SER A 814
ASP A 970
CYH A 979
 None
 1.00A 2br4E-5vhaA:
3.5		 2br4E-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		3 / 3 ASP A 189
ASP A 248
ASP A 196
 None
 0.75A 2igtA-5vhaA:
4.8		 2igtA-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		4 / 5 ASP A 168
LEU A 808
GLY A 809
ARG A 816
 None
 1.13A 2j2pA-5vhaA:
undetectable
2j2pB-5vhaA:
undetectable		 2j2pA-5vhaA:
17.26
2j2pB-5vhaA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		4 / 4 ASP A 168
LEU A 808
GLY A 809
ARG A 816
 None
 1.14A 2j2pD-5vhaA:
undetectable
2j2pE-5vhaA:
undetectable		 2j2pD-5vhaA:
17.26
2j2pE-5vhaA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		4 / 6 PHE A 883
ILE A 848
VAL A 861
ALA A 846
 None
 0.94A 2j5mA-5vhaA:
undetectable		 2j5mA-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		3 / 3 PHE A 883
SER A 875
LEU A 901
 None
 0.78A 2w1bA-5vhaA:
undetectable		 2w1bA-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		5 / 10 ALA A 712
LEU A 807
LEU A 721
VAL A 720
ILE A 704
 None
 1.08A 2w9hA-5vhaA:
undetectable		 2w9hA-5vhaA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		4 / 5 THR A 577
THR A 553
HIS A 527
LEU A 529
 None
 1.31A 2zj0A-5vhaA:
3.4		 2zj0A-5vhaA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		4 / 7 PHE A 714
PHE A 915
ILE A 986
ASN A 829
 None
 1.23A 2zseA-5vhaA:
undetectable		 2zseA-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		4 / 5 THR A 577
THR A 553
HIS A 527
LEU A 529
 None
 1.36A 3ce6A-5vhaA:
3.4		 3ce6A-5vhaA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		4 / 5 THR A 577
THR A 553
HIS A 527
LEU A 529
 None
 1.33A 3ce6C-5vhaA:
3.1		 3ce6C-5vhaA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		3 / 3 CYH A 911
PHE A 914
PHE A 915
 None
 0.91A 3cr5X-5vhaA:
2.4		 3cr5X-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		5 / 12 THR A 234
VAL A 565
VAL A 395
VAL A 538
ILE A 560
 None
 1.24A 3dl9A-5vhaA:
undetectable		 3dl9A-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		4 / 8 SER A 291
THR A 292
ASN A 290
CYH A 286
 None
 0.90A 3dmtC-5vhaA:
2.2		 3dmtC-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		3 / 3 ARG A 482
ILE A 523
THR A 542
 None
 0.73A 3ia4D-5vhaA:
undetectable		 3ia4D-5vhaA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		4 / 8 ARG A 604
VAL A 274
VAL A 278
GLN A 265
 None
 0.89A 3uy4A-5vhaA:
undetectable		 3uy4A-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_B_CVDB1360_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		5 / 12 LEU A 625
TRP A 592
ASP A 469
TRP A 445
TYR A 441
 None
 1.45A 4amjB-5vhaA:
undetectable		 4amjB-5vhaA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		3 / 3 HIS A 703
GLU A 639
ASN A 584
 None
 1.02A 4bupB-5vhaA:
0.4		 4bupB-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		4 / 8 LEU A 362
PHE A 380
THR A 350
ASP A 354
 None
 0.92A 4drjB-5vhaA:
undetectable		 4drjB-5vhaA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		3 / 3 LYS A 752
THR A 754
ILE A 833
 None
 0.91A 4e0fB-5vhaA:
undetectable		 4e0fB-5vhaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		5 / 11 ILE A 317
LEU A 348
THR A 350
VAL A 352
LEU A 321
 None
 1.01A 4g1bB-5vhaA:
undetectable		 4g1bB-5vhaA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		5 / 9 ILE A 317
THR A 314
LEU A 348
VAL A 352
LEU A 321
 None
 1.18A 4g1bC-5vhaA:
undetectable		 4g1bC-5vhaA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		5 / 12 ILE A 317
LEU A 348
THR A 350
VAL A 352
LEU A 321
 None
 1.03A 4g1bD-5vhaA:
2.7		 4g1bD-5vhaA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		3 / 3 GLU A 576
ARG A 635
HIS A 578
 None
 0.82A 4kf9A-5vhaA:
undetectable		 4kf9A-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		5 / 12 GLU A 465
LEU A 449
ASP A 462
ARG A 453
ILE A 404
 None
 1.26A 4mwvA-5vhaA:
undetectable		 4mwvA-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		4 / 6 PHE A 915
GLY A 916
ILE A 944
ILE A 936
 None
 0.77A 4o8fB-5vhaA:
undetectable		 4o8fB-5vhaA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		3 / 3 GLU A 805
ARG A 816
GLN A 535
 None
 0.91A 4rtbA-5vhaA:
undetectable		 4rtbA-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		5 / 10 GLY A 571
ASN A 502
ALA A 479
ILE A 403
LEU A 616
 None
 1.08A 4xj7A-5vhaA:
undetectable
4xj7B-5vhaA:
undetectable		 4xj7A-5vhaA:
13.03
4xj7B-5vhaA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		5 / 10 LEU A 616
GLY A 571
ASN A 502
ALA A 479
ILE A 403
 None
 1.12A 4xj7C-5vhaA:
undetectable
4xj7D-5vhaA:
undetectable		 4xj7C-5vhaA:
13.03
4xj7D-5vhaA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		5 / 10 ALA A 275
VAL A 278
SER A 308
SER A 291
GLY A 293
 None
 1.37A 4xp1A-5vhaA:
undetectable		 4xp1A-5vhaA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		4 / 6 ARG A 282
ARG A 304
ASP A 248
ASP A 189
 None
 1.35A 4xqeA-5vhaA:
2.2		 4xqeA-5vhaA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		4 / 6 ARG A 282
ARG A 304
ASP A 248
ASP A 189
 None
 1.37A 4xqeB-5vhaA:
2.1		 4xqeB-5vhaA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		4 / 7 ASN A 829
LYS A 831
LEU A 713
PHE A 812
 None
 0.95A 4yv5A-5vhaA:
undetectable		 4yv5A-5vhaA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		5 / 11 LEU A 476
TYR A 409
ILE A 569
LEU A 509
LEU A 506
 None
 1.46A 4yvpA-5vhaA:
undetectable		 4yvpA-5vhaA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		4 / 6 ILE A 272
GLN A 299
ILE A 316
ASP A 168
 None
 1.20A 4z4cA-5vhaA:
undetectable		 4z4cA-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		4 / 7 ILE A 848
PHE A 883
VAL A 861
ILE A 871
 None
 0.93A 4zzbC-5vhaA:
undetectable
4zzbD-5vhaA:
undetectable		 4zzbC-5vhaA:
undetectable
4zzbD-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		5 / 12 LEU A 807
PHE A 812
LEU A 955
LEU A 982
ALA A 839
 None
 1.25A 5ieoA-5vhaA:
undetectable		 5ieoA-5vhaA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		4 / 7 ILE A 261
VAL A 262
TYR A 171
ARG A 260
 None
 1.27A 5kkzC-5vhaA:
undetectable
5kkzE-5vhaA:
undetectable		 5kkzC-5vhaA:
undetectable
5kkzE-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		4 / 7 ILE A 261
VAL A 262
TYR A 171
ARG A 260
 None
 1.28A 5kkzK-5vhaA:
undetectable
5kkzQ-5vhaA:
undetectable		 5kkzK-5vhaA:
undetectable
5kkzQ-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		5 / 10 THR A 234
ALA A 369
THR A 370
ALA A 596
ASP A 627
 None
 1.15A 5lf3H-5vhaA:
undetectable
5lf3I-5vhaA:
undetectable		 5lf3H-5vhaA:
13.60
5lf3I-5vhaA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		5 / 10 THR A 234
ALA A 369
THR A 370
ALA A 596
ASP A 627
 None
 1.14A 5lf3V-5vhaA:
undetectable
5lf3W-5vhaA:
undetectable		 5lf3V-5vhaA:
13.60
5lf3W-5vhaA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		5 / 11 ALA A 590
ASP A 473
HIS A 615
VAL A 568
ILE A 569
 None
 1.30A 5y80A-5vhaA:
undetectable		 5y80A-5vhaA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36
(Bos
taurus) 		5 / 9 LEU A 759
THR A 905
ILE A 837
VAL A 720
ILE A 833
 None
 1.30A 6ef6A-5vhaA:
undetectable		 6ef6A-5vhaA:
undetectable