SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vhi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens) 		5 / 12 VAL f 229
LEU f 248
ASN f 245
MET f 209
GLU f 210
 None
 1.27A 1a27A-5vhif:
undetectable		 1a27A-5vhif:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens) 		3 / 3 ASP f 784
ARG f 785
ILE f 660
 None
 0.88A 1a4gB-5vhif:
undetectable		 1a4gB-5vhif:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 6
(Homo
sapiens) 		5 / 11 ASP Y 139
LEU Y 138
GLY Y 135
TYR Y 143
VAL Y 141
 None
 1.50A 1axwB-5vhiY:
undetectable		 1axwB-5vhiY:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 8
(Homo
sapiens) 		5 / 12 GLU d  56
GLN d  60
LEU d  78
TYR d  82
GLY d 100
 None
 1.03A 1httB-5vhid:
undetectable		 1httB-5vhid:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 8
(Homo
sapiens) 		5 / 12 GLU d  56
GLN d  60
LEU d  78
TYR d  82
GLY d 100
 None
 1.05A 1httC-5vhid:
undetectable		 1httC-5vhid:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 8
(Homo
sapiens) 		5 / 12 GLU d  56
GLN d  60
LEU d  78
TYR d  82
GLY d 100
 None
 0.94A 1httD-5vhid:
undetectable		 1httD-5vhid:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 6
(Homo
sapiens) 		5 / 9 LEU Y 149
VAL Y 189
VAL Y 182
TYR Y 222
GLY Y 185
 None
 1.40A 1vrtA-5vhiY:
undetectable		 1vrtA-5vhiY:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 8
(Homo
sapiens) 		4 / 5 LEU d 119
LEU d 103
LEU d 107
LEU d 122
 None
 1.04A 1yajD-5vhid:
undetectable		 1yajD-5vhid:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 8
(Homo
sapiens) 		4 / 5 LEU d  30
LEU d  33
LEU d  48
LEU d  50
 None
 1.03A 2ab2B-5vhid:
undetectable		 2ab2B-5vhid:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens) 		4 / 8 ASN f 565
HIS f 566
GLU f 574
ALA f 572
 None
 1.00A 2bnnA-5vhif:
undetectable
2bnnB-5vhif:
undetectable		 2bnnA-5vhif:
12.98
2bnnB-5vhif:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 6
(Homo
sapiens) 		5 / 10 LEU Y 149
VAL Y 189
VAL Y 182
TYR Y 222
GLY Y 185
 None
 1.43A 2hnyA-5vhiY:
undetectable		 2hnyA-5vhiY:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens) 		4 / 4 ASP f 636
ASP f 630
ASP f 638
GLY f 602
 None
 1.35A 2igtC-5vhif:
undetectable		 2igtC-5vhif:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2N27_A_4DYA205_1
(CALMODULIN)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens) 		5 / 11 LEU f 692
ILE f 660
LEU f 487
MET f 524
VAL f 801
 None
 1.05A 2n27A-5vhif:
undetectable		 2n27A-5vhif:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 8
(Homo
sapiens) 		3 / 3 PRO d 136
GLY d 100
TYR d 132
 None
 0.70A 2vouA-5vhid:
undetectable		 2vouA-5vhid:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 8
(Homo
sapiens) 		3 / 3 PRO d 136
GLY d 100
TYR d 132
 None
 0.59A 2vouB-5vhid:
undetectable		 2vouB-5vhid:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 8
(Homo
sapiens) 		3 / 3 PRO d 136
GLY d 100
TYR d 132
 None
 0.57A 2vouC-5vhid:
undetectable		 2vouC-5vhid:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens) 		5 / 12 LEU f 445
LEU f 487
GLY f 486
CYH f 459
VAL f 497
 None
 1.42A 2w8yA-5vhif:
undetectable		 2w8yA-5vhif:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 6
(Homo
sapiens) 		4 / 6 ARG Y 101
ASP Y 139
LEU Y 180
GLU Y 170
 None
 0.80A 2ya7A-5vhiY:
undetectable		 2ya7A-5vhiY:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 6
(Homo
sapiens) 		4 / 6 ARG Y 101
ASP Y 139
LEU Y 180
GLU Y 170
 None
 0.78A 2ya7B-5vhiY:
undetectable		 2ya7B-5vhiY:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 6
(Homo
sapiens) 		4 / 6 ARG Y 101
ASP Y 139
LEU Y 180
GLU Y 170
 None
 0.79A 2ya7D-5vhiY:
undetectable		 2ya7D-5vhiY:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 6
(Homo
sapiens) 		3 / 3 TYR Y 225
VAL Y 278
THR Y 221
 None
 0.70A 2ygnA-5vhiY:
undetectable		 2ygnA-5vhiY:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 8
(Homo
sapiens) 		5 / 11 LEU d 104
GLY d 100
LYS d 134
PRO d 136
SER d 138
 None
 1.28A 3bjwB-5vhid:
undetectable		 3bjwB-5vhid:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 8
(Homo
sapiens) 		5 / 11 LEU d 104
GLY d 100
LYS d 134
PRO d 136
SER d 138
 None
 1.29A 3bjwH-5vhid:
undetectable		 3bjwH-5vhid:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 8
(Homo
sapiens) 		4 / 7 ASP d  53
ALA d  51
TYR d  81
TYR d  82
 None
 1.14A 3rodD-5vhid:
undetectable		 3rodD-5vhid:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 8
(Homo
sapiens) 		3 / 3 LEU d  99
HIS d  96
MET d  95
 None
 0.91A 3thrD-5vhid:
undetectable		 3thrD-5vhid:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens) 		5 / 9 LEU f 249
GLN f 213
GLU f 210
PHE f 256
VAL f 255
 None
 1.30A 3tmzA-5vhif:
undetectable		 3tmzA-5vhif:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 8
(Homo
sapiens) 		4 / 5 LEU d 103
LEU d 107
LEU d 139
SER d 138
 None
 0.93A 3vhuA-5vhid:
undetectable		 3vhuA-5vhid:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens) 		4 / 6 GLN f  81
ARG f  80
ASP f 124
GLU f 182
 None
 1.48A 4azvA-5vhif:
undetectable		 4azvA-5vhif:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens) 		5 / 12 LEU f 433
TYR f 432
GLY f 415
GLY f 379
GLY f 424
 None
 1.16A 4blvA-5vhif:
undetectable		 4blvA-5vhif:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 6
(Homo
sapiens) 		5 / 12 THR Y 218
ALA Y 190
ASP Y 193
ALA Y 197
VAL Y 226
 None
 1.44A 4df3A-5vhiY:
undetectable		 4df3A-5vhiY:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 6
(Homo
sapiens) 		5 / 12 THR Y 218
ALA Y 190
ASP Y 193
ALA Y 197
VAL Y 226
 None
 1.47A 4df3B-5vhiY:
undetectable		 4df3B-5vhiY:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens) 		3 / 3 ASP f 496
ARG f 494
ASP f 460
 None
 0.78A 4fp9C-5vhif:
undetectable		 4fp9C-5vhif:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens) 		3 / 3 ASP f 496
ARG f 494
ASP f 460
 None
 0.80A 4fp9F-5vhif:
undetectable		 4fp9F-5vhif:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 6
(Homo
sapiens) 		4 / 7 ARG Y 146
GLY Y 148
ALA Y 120
GLN Y  21
 None
 0.97A 4g0uB-5vhiY:
undetectable		 4g0uB-5vhiY:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 6
(Homo
sapiens) 		4 / 6 ARG Y 146
GLY Y 148
ALA Y 120
GLN Y  21
 None
 0.94A 4g0uA-5vhiY:
undetectable		 4g0uA-5vhiY:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens) 		4 / 5 LEU f 560
ASP f 784
ARG f 785
ILE f 660
 None
 1.17A 4mwrA-5vhif:
undetectable		 4mwrA-5vhif:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens) 		4 / 4 ASN f 371
LEU f 391
PHE f 376
TYR f 751
 None
 1.11A 4u14A-5vhif:
undetectable		 4u14A-5vhif:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens) 		4 / 7 ASN f 402
LYS f 403
TYR f 439
LEU f 446
 None
 1.14A 4yv5A-5vhif:
undetectable		 4yv5A-5vhif:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 6
(Homo
sapiens) 		4 / 6 ARG Y 101
ASP Y 139
ARG Y 146
ILE Y 140
 None
 1.22A 5a06A-5vhiY:
undetectable		 5a06A-5vhiY:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens) 		4 / 5 SER f 409
ALA f 410
MET f 416
LEU f 372
 None
 1.26A 5dzkb-5vhif:
undetectable
5dzkp-5vhif:
undetectable		 5dzkb-5vhif:
13.63
5dzkp-5vhif:
1.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens) 		4 / 5 SER f 409
ALA f 410
MET f 416
LEU f 372
 None
 1.24A 5dzkc-5vhif:
undetectable
5dzkq-5vhif:
undetectable		 5dzkc-5vhif:
13.63
5dzkq-5vhif:
1.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens) 		4 / 5 SER f 409
ALA f 410
MET f 416
LEU f 372
 None
 1.28A 5dzkf-5vhif:
undetectable
5dzkt-5vhif:
undetectable		 5dzkf-5vhif:
13.63
5dzkt-5vhif:
1.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens) 		4 / 6 SER f 409
ALA f 410
MET f 416
LEU f 372
 None
 1.21A 5dzkg-5vhif:
undetectable
5dzku-5vhif:
undetectable		 5dzkg-5vhif:
13.63
5dzku-5vhif:
1.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 8
(Homo
sapiens) 		5 / 12 GLU d  56
GLN d  60
LEU d  78
TYR d  82
GLY d 100
 None
 1.11A 5e3iA-5vhid:
undetectable		 5e3iA-5vhid:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens) 		5 / 12 GLU f 312
LEU f 501
ALA f 526
SER f 529
THR f 499
 None
 1.08A 5hnzB-5vhif:
undetectable		 5hnzB-5vhif:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
14
(Homo
sapiens) 		4 / 5 HIS c 113
HIS c 115
VAL c 144
ALA c 142
 None
 1.06A 5i3bB-5vhic:
undetectable		 5i3bB-5vhic:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
14
(Homo
sapiens) 		4 / 8 ILE c 203
ARG c 161
TYR c 200
VAL c 143
 None
 1.16A 5vlmF-5vhic:
2.1		 5vlmF-5vhic:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens) 		4 / 5 ASN f 473
VAL f 504
LEU f 501
SER f 481
 None
 1.17A 6a7pA-5vhif:
undetectable		 6a7pA-5vhif:
20.25