SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vhj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 5vhj 26S PROTEASOME
REGULATORY SUBUNIT
10B
(Homo
sapiens) 		4 / 5 LYS E 298
PHE E 231
LEU E 295
LEU E 182
 None
 1.29A 1skxA-5vhjE:
undetectable		 1skxA-5vhjE:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5vhj 26S PROTEASOME
REGULATORY SUBUNIT 8
(Homo
sapiens) 		5 / 11 GLU C 323
ALA C 324
ILE C 328
ALA C 348
PRO C 320
 None
 1.21A 2admA-5vhjC:
undetectable		 2admA-5vhjC:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5vhj 26S PROTEASOME
REGULATORY SUBUNIT 8
(Homo
sapiens) 		5 / 11 GLU C 323
ALA C 324
ILE C 328
ALA C 348
PRO C 320
 None
 1.18A 2admB-5vhjC:
undetectable		 2admB-5vhjC:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 5vhj 26S PROTEASOME
REGULATORY SUBUNIT 4
(Homo
sapiens) 		5 / 12 ASP B 285
GLY B 231
GLY B 229
ALA B 330
ASP B 389
 None
 1.07A 2c49A-5vhjB:
undetectable		 2c49A-5vhjB:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5vhj 26S PROTEASOME
REGULATORY SUBUNIT
10B
(Homo
sapiens) 		5 / 10 THR E 284
THR E 279
ALA E 278
GLY E 239
ALA E 237
 None
 0.97A 2f16K-5vhjE:
undetectable
2f16L-5vhjE:
undetectable		 2f16K-5vhjE:
22.54
2f16L-5vhjE:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5vhj 26S PROTEASOME
REGULATORY SUBUNIT 7
(Homo
sapiens) 		5 / 11 LEU A 337
ASP A 307
LEU A 306
ILE A 303
ILE A 277
 None
 1.06A 2w9sB-5vhjA:
undetectable		 2w9sB-5vhjA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 5vhj 26S PROTEASOME
REGULATORY SUBUNIT
6A
(Homo
sapiens) 		4 / 5 ALA F 385
GLY F 393
CYH F 396
LYS F 397
 None
 1.32A 2ylgA-5vhjF:
undetectable		 2ylgA-5vhjF:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5vhj 26S PROTEASOME
REGULATORY SUBUNIT 4
(Homo
sapiens) 		4 / 6 LEU B 341
ILE B 290
ALA B 289
THR B 331
 None
 1.08A 3mdrA-5vhjB:
undetectable		 3mdrA-5vhjB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 5vhj 26S PROTEASOME
REGULATORY SUBUNIT
10B
(Homo
sapiens) 		5 / 11 THR E 178
GLY E 177
PRO E 176
PRO E 304
ASP E 302
 None
 1.02A 3t8nD-5vhjE:
undetectable
3t8nF-5vhjE:
undetectable		 3t8nD-5vhjE:
18.42
3t8nF-5vhjE:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 5vhj 26S PROTEASOME
REGULATORY SUBUNIT 4
(Homo
sapiens) 		4 / 5 THR B 331
GLY B 229
PRO B 227
ASN B 332
 None
 0.86A 3u8qA-5vhjB:
undetectable		 3u8qA-5vhjB:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 5vhj 26S PROTEASOME
REGULATORY SUBUNIT
10B
(Homo
sapiens) 		4 / 5 LEU E 270
ILE E 230
MET E 275
PHE E 219
 None
 0.96A 4dc3B-5vhjE:
undetectable		 4dc3B-5vhjE:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 5vhj 26S PROTEASOME
REGULATORY SUBUNIT 4
(Homo
sapiens) 		4 / 6 THR B 331
GLY B 229
PRO B 227
ASN B 332
 None
 0.89A 4fjpA-5vhjB:
undetectable		 4fjpA-5vhjB:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 5vhj 26S PROTEASOME
REGULATORY SUBUNIT 4
(Homo
sapiens) 		3 / 3 LYS B 237
LEU B 234
ALA B 236
 None
 0.73A 4ikiA-5vhjB:
undetectable		 4ikiA-5vhjB:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5vhj 26S PROTEASOME
REGULATORY SUBUNIT 7
(Homo
sapiens) 		5 / 12 ASP A 325
LEU A 327
GLU A 276
GLY A 281
ALA A 283
 None
 1.24A 4xe5A-5vhjA:
2.8		 4xe5A-5vhjA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 5vhj 26S PROTEASOME
REGULATORY SUBUNIT
6A
(Homo
sapiens) 		4 / 5 ALA F 385
GLY F 393
CYH F 396
LYS F 397
 None
 1.41A 5jliA-5vhjF:
undetectable		 5jliA-5vhjF:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5vhj 26S PROTEASOME
REGULATORY SUBUNIT
10B
(Homo
sapiens) 		5 / 9 THR E 284
THR E 279
ALA E 278
GLY E 239
ALA E 237
 None
 1.01A 5l5zK-5vhjE:
undetectable
5l5zL-5vhjE:
undetectable		 5l5zK-5vhjE:
21.15
5l5zL-5vhjE:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5vhj 26S PROTEASOME
REGULATORY SUBUNIT
10B
(Homo
sapiens) 		5 / 9 THR E 284
THR E 279
ALA E 278
GLY E 239
ALA E 237
 None
 1.01A 5l5zY-5vhjE:
undetectable
5l5zZ-5vhjE:
undetectable		 5l5zY-5vhjE:
21.15
5l5zZ-5vhjE:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vhj 26S PROTEASOME
REGULATORY SUBUNIT
10B
(Homo
sapiens) 		5 / 11 THR E 284
THR E 279
ALA E 278
GLY E 239
ALA E 237
 None
 0.92A 5lf3K-5vhjE:
undetectable
5lf3L-5vhjE:
undetectable		 5lf3K-5vhjE:
21.51
5lf3L-5vhjE:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 5vhj 26S PROTEASOME
REGULATORY SUBUNIT
10B
(Homo
sapiens) 		5 / 11 THR E 284
THR E 279
ALA E 278
GLY E 239
ALA E 237
 None
 0.93A 5lf3Y-5vhjE:
undetectable
5lf3Z-5vhjE:
undetectable		 5lf3Y-5vhjE:
21.51
5lf3Z-5vhjE:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 5vhj 26S PROTEASOME
REGULATORY SUBUNIT 4
(Homo
sapiens) 		5 / 12 GLN B 315
LEU B 313
LEU B 312
GLU B 311
LEU B 310
 None
 1.25A 5nwwA-5vhjB:
undetectable		 5nwwA-5vhjB:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5vhj 26S PROTEASOME
REGULATORY SUBUNIT 8
(Homo
sapiens) 		5 / 12 ASP C 394
LEU C 338
LEU C 344
ALA C 348
GLY C 361
 None
 0.99A 6b0iB-5vhjC:
undetectable		 6b0iB-5vhjC:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5vhj 26S PROTEASOME
REGULATORY SUBUNIT 8
(Homo
sapiens) 		4 / 6 ASP C 394
GLN C 392
GLU C 358
THR C 364
 None
 1.33A 6djzA-5vhjC:
undetectable		 6djzA-5vhjC:
22.11