SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vho'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K4T_D_TTCD990_1
(DNA TOPOISOMERASE I)		 5vho 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
10
26S PROTEASOME
REGULATORY SUBUNIT
6B
(Homo
sapiens) 		4 / 5 GLU G 187
ARG D 338
LYS D 369
ASP D 368
 None
 1.34A 1k4tA-5vhoG:
undetectable		 1k4tA-5vhoG:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RR8_A_TTCA100_1
(DNA TOPOISOMERASE I)		 5vho 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
10
26S PROTEASOME
REGULATORY SUBUNIT
6B
(Homo
sapiens) 		4 / 5 GLU G 187
ARG D 338
LYS D 369
ASP D 368
 None
 1.37A 1rr8C-5vhoG:
undetectable		 1rr8C-5vhoG:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RRJ_B_TTCB990_1
(DNA TOPOISOMERASE I)		 5vho 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
10
26S PROTEASOME
REGULATORY SUBUNIT
6B
(Homo
sapiens) 		4 / 5 GLU G 187
ARG D 338
LYS D 369
ASP D 368
 None
 1.36A 1rrjA-5vhoG:
undetectable		 1rrjA-5vhoG:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 5vho 26S PROTEASOME
REGULATORY SUBUNIT
6B
(Homo
sapiens) 		5 / 12 LEU D 321
LEU D 327
LEU D 317
ALA D 271
ILE D 270
 None
 1.10A 1tw4A-5vhoD:
undetectable		 1tw4A-5vhoD:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5vho 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
10
(Homo
sapiens) 		5 / 12 LEU G 191
GLU G 182
GLY G 150
ALA G 146
ALA G 114
 None
 1.15A 2bm9D-5vhoG:
undetectable		 2bm9D-5vhoG:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 5vho 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
10
26S PROTEASOME
REGULATORY SUBUNIT
6B
(Homo
sapiens) 		5 / 12 TYR G  15
LEU D 395
VAL D 394
SER G  49
LEU D 360
 None
 1.13A 3m7rA-5vhoG:
undetectable		 3m7rA-5vhoG:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5vho 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
10
(Homo
sapiens) 		5 / 12 LEU G  93
ALA G 130
GLY G 128
LEU G 126
ALA G 134
 None
 1.30A 3ou7C-5vhoG:
undetectable		 3ou7C-5vhoG:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vho 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
10
(Homo
sapiens) 		5 / 11 ALA G 122
ALA G 113
GLY G 128
GLY G 129
ALA G 130
 None
 0.85A 6hwdK-5vhoG:
undetectable
6hwdL-5vhoG:
undetectable		 6hwdK-5vhoG:
17.53
6hwdL-5vhoG:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vho 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
10
(Homo
sapiens) 		5 / 11 ALA G 122
ALA G 113
GLY G 128
GLY G 129
ALA G 130
 None
 0.84A 6hwdY-5vhoG:
undetectable
6hwdZ-5vhoG:
undetectable		 6hwdY-5vhoG:
17.53
6hwdZ-5vhoG:
17.47