SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vhs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 5vhs 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 3
(Homo
sapiens) 		4 / 4 THR V 327
LEU V 331
VAL V 334
LEU V 338
 None
 0.97A 1fbmB-5vhsV:
undetectable		 1fbmB-5vhsV:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5vhs 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 3
(Homo
sapiens) 		4 / 7 TYR V 360
THR V 391
THR V 393
VAL V 334
 None
 1.18A 1tv8A-5vhsV:
undetectable		 1tv8A-5vhsV:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 5vhs 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 3
(Homo
sapiens) 		4 / 6 SER V 415
ILE V 447
ALA V 441
ALA V 434
 None
 0.79A 1w0gA-5vhsV:
undetectable		 1w0gA-5vhsV:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 5vhs 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 3
(Homo
sapiens) 		4 / 7 ASP V 380
THR V 391
GLY V 390
TYR V 392
 None
 1.06A 2f6dA-5vhsV:
undetectable		 2f6dA-5vhsV:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5vhs 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 3
(Homo
sapiens) 		4 / 8 TYR V 360
THR V 391
THR V 393
VAL V 334
 None
 1.13A 2fb2A-5vhsV:
undetectable		 2fb2A-5vhsV:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5vhs 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 3
(Homo
sapiens) 		4 / 7 TYR V 360
THR V 391
THR V 393
VAL V 334
 None
 1.02A 2fb2B-5vhsV:
undetectable		 2fb2B-5vhsV:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5vhs 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 3
(Homo
sapiens) 		3 / 3 VAL V 438
VAL V 458
SER V 460
 None
 0.52A 3n8xB-5vhsV:
undetectable		 3n8xB-5vhsV:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5vhs 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 3
(Homo
sapiens) 		4 / 6 PRO V 343
ARG V 368
THR V 364
ILE V 333
 None
 1.24A 5ih0A-5vhsV:
undetectable		 5ih0A-5vhsV:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5vhs 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 3
(Homo
sapiens) 		5 / 10 VAL V 367
ALA V 366
LEU V 337
LEU V 379
LEU V 398
 None
 0.88A 6f5uA-5vhsV:
undetectable
6f5uB-5vhsV:
undetectable		 6f5uA-5vhsV:
10.42
6f5uB-5vhsV:
9.41