SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vi6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		8 / 11 HIS A 142
HIS A 143
PHE A 152
ASP A 178
HIS A 180
PHE A 208
ASP A 267
TYR A 306
 None
EDO  A 410 (-4.4A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
EDO  A 410 ( 3.7A)
ZN  A 401 (-2.4A)
EDO  A 407 ( 3.3A)
 0.38A 1c3sA-5vi6A:
44.8		 1c3sA-5vi6A:
32.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		4 / 6 GLN A 263
TYR A 174
ASP A 178
GLY A 182
 None
None
ZN  A 401 ( 2.3A)
None
 1.28A 1ekjC-5vi6A:
1.7
1ekjD-5vi6A:
1.7		 1ekjC-5vi6A:
19.74
1ekjD-5vi6A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		4 / 6 ASP A 178
GLY A 182
GLN A 263
TYR A 174
 ZN  A 401 ( 2.3A)
None
None
None
 1.26A 1ekjC-5vi6A:
undetectable
1ekjD-5vi6A:
undetectable		 1ekjC-5vi6A:
19.74
1ekjD-5vi6A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		4 / 7 ASP A 178
HIS A 142
GLY A 303
GLY A 302
 ZN  A 401 ( 2.3A)
None
None
None
 0.99A 1ekjE-5vi6A:
undetectable
1ekjF-5vi6A:
undetectable		 1ekjE-5vi6A:
19.74
1ekjF-5vi6A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 11 LEU A 301
LEU A 126
ALA A 122
LEU A 165
THR A 119
 None
 1.26A 1ictA-5vi6A:
undetectable
1ictC-5vi6A:
undetectable		 1ictA-5vi6A:
16.49
1ictC-5vi6A:
16.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		11 / 12 ASP A 101
HIS A 142
HIS A 143
GLY A 151
PHE A 152
ASP A 178
HIS A 180
PHE A 208
ASP A 267
MET A 274
TYR A 306
 None
None
EDO  A 410 (-4.4A)
EDO  A 410 ( 4.8A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
EDO  A 410 ( 3.7A)
ZN  A 401 (-2.4A)
EDO  A 407 (-4.1A)
EDO  A 407 ( 3.3A)
 0.35A 1t69A-5vi6A:
62.4		 1t69A-5vi6A:
98.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 10 THR A 268
ASP A 272
GLY A 265
GLY A 304
ILE A 348
 None
None
None
ZN  A 401 ( 4.2A)
EDO  A 408 (-3.9A)
 1.09A 1x7pA-5vi6A:
undetectable
1x7pB-5vi6A:
undetectable		 1x7pA-5vi6A:
20.88
1x7pB-5vi6A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 11 HIS A 142
HIS A 143
PHE A 152
ASP A 178
GLY A 303
 None
EDO  A 410 (-4.4A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
None
 1.03A 1zz1A-5vi6A:
42.2		 1zz1A-5vi6A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		9 / 11 HIS A 142
HIS A 143
PHE A 152
ASP A 178
HIS A 180
PHE A 208
ASP A 267
GLY A 304
TYR A 306
 None
EDO  A 410 (-4.4A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
EDO  A 410 ( 3.7A)
ZN  A 401 (-2.4A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 0.55A 1zz1A-5vi6A:
42.2		 1zz1A-5vi6A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 11 HIS A 142
HIS A 180
ASP A 267
GLY A 304
TYR A 306
 None
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.4A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 1.06A 1zz1A-5vi6A:
42.2		 1zz1A-5vi6A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 12 HIS A 142
HIS A 143
PHE A 152
ASP A 178
GLY A 303
 None
EDO  A 410 (-4.4A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
None
 1.01A 1zz1B-5vi6A:
42.3
1zz1C-5vi6A:
42.3		 1zz1B-5vi6A:
26.91
1zz1C-5vi6A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		9 / 12 HIS A 142
HIS A 143
PHE A 152
ASP A 178
HIS A 180
PHE A 208
ASP A 267
GLY A 304
TYR A 306
 None
EDO  A 410 (-4.4A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
EDO  A 410 ( 3.7A)
ZN  A 401 (-2.4A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 0.49A 1zz1B-5vi6A:
42.3
1zz1C-5vi6A:
42.3		 1zz1B-5vi6A:
26.91
1zz1C-5vi6A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 12 HIS A 142
HIS A 180
ASP A 267
GLY A 304
TYR A 306
 None
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.4A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 1.03A 1zz1B-5vi6A:
42.3
1zz1C-5vi6A:
42.3		 1zz1B-5vi6A:
26.91
1zz1C-5vi6A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 12 HIS A 142
HIS A 143
GLY A 151
ASP A 178
GLY A 303
 None
EDO  A 410 (-4.4A)
EDO  A 410 ( 4.8A)
ZN  A 401 ( 2.3A)
None
 0.83A 1zz1C-5vi6A:
42.3		 1zz1C-5vi6A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		9 / 12 HIS A 142
HIS A 143
GLY A 151
ASP A 178
HIS A 180
PHE A 208
ASP A 267
GLY A 304
TYR A 306
 None
EDO  A 410 (-4.4A)
EDO  A 410 ( 4.8A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
EDO  A 410 ( 3.7A)
ZN  A 401 (-2.4A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 0.52A 1zz1C-5vi6A:
42.3		 1zz1C-5vi6A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 12 HIS A 142
HIS A 180
ASP A 267
GLY A 304
TYR A 306
 None
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.4A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 1.06A 1zz1C-5vi6A:
42.3		 1zz1C-5vi6A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_D_SHHD2752_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		8 / 9 HIS A 142
HIS A 143
PHE A 152
ASP A 178
HIS A 180
PHE A 208
ASP A 267
TYR A 306
 None
EDO  A 410 (-4.4A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
EDO  A 410 ( 3.7A)
ZN  A 401 (-2.4A)
EDO  A 407 ( 3.3A)
 0.53A 1zz1D-5vi6A:
42.3		 1zz1D-5vi6A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		4 / 8 PRO A 350
VAL A 282
GLY A 283
MET A 279
 None
EDO  A 408 (-4.3A)
None
None
 1.15A 2qd3A-5vi6A:
undetectable		 2qd3A-5vi6A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 11 LEU A 264
VAL A 175
LEU A 318
ILE A 243
ILE A 291
 None
 1.22A 2uxoB-5vi6A:
undetectable		 2uxoB-5vi6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		3 / 3 HIS A 180
HIS A 143
HIS A 142
 ZN  A 401 ( 3.1A)
EDO  A 410 (-4.4A)
None
 0.73A 2y69N-5vi6A:
undetectable		 2y69N-5vi6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		4 / 5 ALA A 122
GLY A 129
CYH A 131
LYS A 132
 None
 1.09A 2ylgA-5vi6A:
undetectable		 2ylgA-5vi6A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		4 / 5 ALA A 123
GLY A 129
CYH A 131
LYS A 132
 None
 1.26A 2ylgA-5vi6A:
undetectable		 2ylgA-5vi6A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		3 / 3 HIS A 180
HIS A 143
HIS A 142
 ZN  A 401 ( 3.1A)
EDO  A 410 (-4.4A)
None
 0.75A 2zxwN-5vi6A:
undetectable		 2zxwN-5vi6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		3 / 3 HIS A 180
HIS A 143
HIS A 142
 ZN  A 401 ( 3.1A)
EDO  A 410 (-4.4A)
None
 0.73A 3abmN-5vi6A:
undetectable		 3abmN-5vi6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		3 / 3 HIS A 180
HIS A 143
HIS A 142
 ZN  A 401 ( 3.1A)
EDO  A 410 (-4.4A)
None
 0.76A 3ag1N-5vi6A:
undetectable		 3ag1N-5vi6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 5 HIS A 142
HIS A 143
ASP A 178
HIS A 180
ASP A 267
 None
EDO  A 410 (-4.4A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.4A)
 0.16A 3c0zA-5vi6A:
39.7		 3c0zA-5vi6A:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 8 HIS A 142
HIS A 143
PHE A 152
ASP A 178
GLY A 303
 None
EDO  A 410 (-4.4A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
None
 1.13A 3c0zB-5vi6A:
40.1		 3c0zB-5vi6A:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		8 / 8 HIS A 142
HIS A 143
PHE A 152
ASP A 178
HIS A 180
PHE A 208
ASP A 267
GLY A 304
 None
EDO  A 410 (-4.4A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
EDO  A 410 ( 3.7A)
ZN  A 401 (-2.4A)
ZN  A 401 ( 4.2A)
 0.39A 3c0zB-5vi6A:
40.1		 3c0zB-5vi6A:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		4 / 8 PHE A 208
ASP A 267
PHE A 152
ASP A 178
 EDO  A 410 ( 3.7A)
ZN  A 401 (-2.4A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
 0.85A 3c0zB-5vi6A:
40.1		 3c0zB-5vi6A:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		6 / 6 ASP A 101
HIS A 142
HIS A 143
ASP A 178
HIS A 180
ASP A 267
 None
None
EDO  A 410 (-4.4A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.4A)
 0.36A 3c0zC-5vi6A:
39.9		 3c0zC-5vi6A:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 12 GLY A 265
GLY A 140
GLY A 139
LEU A 179
ALA A 266
 None
 0.90A 3douA-5vi6A:
3.8		 3douA-5vi6A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 12 LEU A 327
GLY A 285
GLY A 320
LEU A  50
CYH A 314
 None
 1.08A 3e23A-5vi6A:
undetectable		 3e23A-5vi6A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		3 / 3 TYR A 174
ASP A 157
HIS A 143
 None
None
EDO  A 410 (-4.4A)
 0.89A 3e23A-5vi6A:
1.6		 3e23A-5vi6A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 10 ILE A 284
LEU A 248
VAL A 247
VAL A 251
LEU A 173
 None
 0.91A 3gwxA-5vi6A:
undetectable		 3gwxA-5vi6A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 12 ILE A 284
LEU A 248
VAL A 247
VAL A 251
LEU A 173
 None
 0.91A 3gwxB-5vi6A:
undetectable		 3gwxB-5vi6A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 12 GLY A 218
ASP A 187
GLY A 212
SER A 215
ASN A 228
 None
 1.26A 3k13A-5vi6A:
undetectable		 3k13A-5vi6A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 12 GLY A 218
ASP A 187
GLY A 212
SER A 215
ASN A 228
 None
 1.26A 3k13B-5vi6A:
undetectable		 3k13B-5vi6A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 12 GLY A 218
ASP A 187
GLY A 212
SER A 215
ASN A 228
 None
 1.26A 3k13C-5vi6A:
undetectable		 3k13C-5vi6A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 12 GLN A 263
HIS A 142
HIS A 143
LEU A 179
HIS A 201
 None
None
EDO  A 410 (-4.4A)
None
None
 1.35A 3lxeA-5vi6A:
undetectable		 3lxeA-5vi6A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 12 GLN A 263
HIS A 142
HIS A 143
LEU A 179
HIS A 201
 None
None
EDO  A 410 (-4.4A)
None
None
 1.33A 3lxeB-5vi6A:
undetectable		 3lxeB-5vi6A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		4 / 4 GLY A 212
GLU A 186
ASP A 176
ASP A 213
 None
None
K  A 402 (-3.4A)
None
 1.38A 3mb5A-5vi6A:
4.0		 3mb5A-5vi6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		3 / 3 HIS A 180
HIS A 143
HIS A 142
 ZN  A 401 ( 3.1A)
EDO  A 410 (-4.4A)
None
 0.73A 3x2qN-5vi6A:
0.1		 3x2qN-5vi6A:
20.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		8 / 10 HIS A 142
HIS A 143
ASP A 178
HIS A 180
ASP A 267
PRO A 273
GLY A 304
TYR A 306
 None
EDO  A 410 (-4.4A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.4A)
EDO  A 407 ( 3.6A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 0.29A 4bz6A-5vi6A:
54.1		 4bz6A-5vi6A:
38.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		6 / 10 HIS A 142
HIS A 180
ASP A 267
PRO A 273
GLY A 304
TYR A 306
 None
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.4A)
EDO  A 407 ( 3.6A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 1.03A 4bz6A-5vi6A:
54.1		 4bz6A-5vi6A:
38.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		9 / 12 HIS A 142
HIS A 143
ASP A 178
HIS A 180
PHE A 208
ASP A 267
PRO A 273
GLY A 304
TYR A 306
 None
EDO  A 410 (-4.4A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
EDO  A 410 ( 3.7A)
ZN  A 401 (-2.4A)
EDO  A 407 ( 3.6A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 0.32A 4bz6A-5vi6A:
54.1
4bz6B-5vi6A:
54.0		 4bz6A-5vi6A:
38.60
4bz6B-5vi6A:
38.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		6 / 12 HIS A 142
HIS A 180
ASP A 267
PRO A 273
GLY A 304
TYR A 306
 None
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.4A)
EDO  A 407 ( 3.6A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 1.04A 4bz6A-5vi6A:
54.1
4bz6B-5vi6A:
54.0		 4bz6A-5vi6A:
38.60
4bz6B-5vi6A:
38.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 12 HIS A 142
HIS A 143
GLY A 151
ASP A 178
GLY A 303
 None
EDO  A 410 (-4.4A)
EDO  A 410 ( 4.8A)
ZN  A 401 ( 2.3A)
None
 0.85A 4bz6C-5vi6A:
54.0		 4bz6C-5vi6A:
38.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		10 / 12 HIS A 142
HIS A 143
GLY A 151
ASP A 178
HIS A 180
PHE A 208
ASP A 267
PRO A 273
GLY A 304
TYR A 306
 None
EDO  A 410 (-4.4A)
EDO  A 410 ( 4.8A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
EDO  A 410 ( 3.7A)
ZN  A 401 (-2.4A)
EDO  A 407 ( 3.6A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 0.33A 4bz6C-5vi6A:
54.0		 4bz6C-5vi6A:
38.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		6 / 12 HIS A 142
HIS A 180
ASP A 267
PRO A 273
GLY A 304
TYR A 306
 None
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.4A)
EDO  A 407 ( 3.6A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 1.01A 4bz6C-5vi6A:
54.0		 4bz6C-5vi6A:
38.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		10 / 12 LYS A  33
HIS A 142
HIS A 143
ASP A 178
HIS A 180
PHE A 208
ASP A 267
PRO A 273
GLY A 304
TYR A 306
 None
None
EDO  A 410 (-4.4A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
EDO  A 410 ( 3.7A)
ZN  A 401 (-2.4A)
EDO  A 407 ( 3.6A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 0.57A 4bz6C-5vi6A:
54.0		 4bz6C-5vi6A:
38.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		6 / 12 LYS A  33
HIS A 143
HIS A 180
ASP A 267
PRO A 273
TYR A 306
 None
EDO  A 410 (-4.4A)
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.4A)
EDO  A 407 ( 3.6A)
EDO  A 407 ( 3.3A)
 1.27A 4bz6C-5vi6A:
54.0		 4bz6C-5vi6A:
38.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		8 / 10 HIS A 142
HIS A 143
ASP A 178
HIS A 180
ASP A 267
PRO A 273
GLY A 304
TYR A 306
 None
EDO  A 410 (-4.4A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.4A)
EDO  A 407 ( 3.6A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 0.26A 4bz6D-5vi6A:
54.3		 4bz6D-5vi6A:
38.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		6 / 10 HIS A 142
HIS A 180
ASP A 267
PRO A 273
GLY A 304
TYR A 306
 None
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.4A)
EDO  A 407 ( 3.6A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 1.03A 4bz6D-5vi6A:
54.3		 4bz6D-5vi6A:
38.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFV_A_T27A601_1
(EXORIBONUCLEASE H,
P66 RT)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 12 LEU A 288
VAL A 133
VAL A 260
PRO A  16
TRP A 137
 None
 1.41A 4ifvA-5vi6A:
0.7		 4ifvA-5vi6A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 12 ILE A  34
GLY A 265
GLY A 304
ILE A 269
ILE A 284
 EDO  A 412 (-4.1A)
None
ZN  A 401 ( 4.2A)
None
None
 1.15A 4iv0B-5vi6A:
4.1		 4iv0B-5vi6A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 11 GLY A 265
ALA A 266
ASP A 267
ASP A 272
ILE A 231
 None
None
ZN  A 401 (-2.4A)
None
None
 1.12A 4l1aA-5vi6A:
undetectable		 4l1aA-5vi6A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 11 GLY A 265
ALA A 266
ASP A 267
ASP A 272
ILE A 235
 None
None
ZN  A 401 (-2.4A)
None
None
 1.06A 4l1aA-5vi6A:
undetectable		 4l1aA-5vi6A:
14.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		7 / 12 ASP A 101
HIS A 142
HIS A 143
GLY A 151
PHE A 152
ASP A 178
GLY A 303
 None
None
EDO  A 410 (-4.4A)
EDO  A 410 ( 4.8A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
None
 0.94A 4lxzA-5vi6A:
55.4		 4lxzA-5vi6A:
42.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		10 / 12 ASP A 101
HIS A 142
HIS A 143
GLY A 151
PHE A 152
ASP A 178
HIS A 180
ASP A 267
GLY A 304
TYR A 306
 None
None
EDO  A 410 (-4.4A)
EDO  A 410 ( 4.8A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.4A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 0.31A 4lxzA-5vi6A:
55.4		 4lxzA-5vi6A:
42.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 12 HIS A 142
HIS A 180
ASP A 267
GLY A 304
TYR A 306
 None
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.4A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 0.94A 4lxzA-5vi6A:
55.4		 4lxzA-5vi6A:
42.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		6 / 11 ASP A 101
HIS A 142
HIS A 143
PHE A 152
ASP A 178
GLY A 303
 None
None
EDO  A 410 (-4.4A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
None
 1.01A 4lxzB-5vi6A:
55.4		 4lxzB-5vi6A:
42.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		9 / 11 ASP A 101
HIS A 142
HIS A 143
PHE A 152
ASP A 178
HIS A 180
ASP A 267
GLY A 304
TYR A 306
 None
None
EDO  A 410 (-4.4A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.4A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 0.32A 4lxzB-5vi6A:
55.4		 4lxzB-5vi6A:
42.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 11 ASP A 101
HIS A 180
PHE A 152
ASP A 267
GLY A 304
 None
ZN  A 401 ( 3.1A)
EDO  A 407 (-4.2A)
ZN  A 401 (-2.4A)
ZN  A 401 ( 4.2A)
 1.33A 4lxzB-5vi6A:
55.4		 4lxzB-5vi6A:
42.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 11 HIS A 142
HIS A 180
ASP A 267
GLY A 304
TYR A 306
 None
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.4A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 0.97A 4lxzB-5vi6A:
55.4		 4lxzB-5vi6A:
42.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		7 / 12 ASP A 101
HIS A 142
HIS A 143
GLY A 151
PHE A 152
ASP A 178
GLY A 303
 None
None
EDO  A 410 (-4.4A)
EDO  A 410 ( 4.8A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
None
 0.96A 4lxzC-5vi6A:
55.8		 4lxzC-5vi6A:
42.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		11 / 12 ASP A 101
HIS A 142
HIS A 143
GLY A 151
PHE A 152
ASP A 178
HIS A 180
PHE A 208
ASP A 267
GLY A 304
TYR A 306
 None
None
EDO  A 410 (-4.4A)
EDO  A 410 ( 4.8A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
EDO  A 410 ( 3.7A)
ZN  A 401 (-2.4A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 0.33A 4lxzC-5vi6A:
55.8		 4lxzC-5vi6A:
42.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 12 HIS A 142
HIS A 180
ASP A 267
GLY A 304
TYR A 306
 None
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.4A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 0.96A 4lxzC-5vi6A:
55.8		 4lxzC-5vi6A:
42.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		6 / 12 HIS A 142
HIS A 143
GLY A 151
PHE A 152
ASP A 178
GLY A 303
 None
EDO  A 410 (-4.4A)
EDO  A 410 ( 4.8A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
None
 0.99A 4qa0A-5vi6A:
63.7		 4qa0A-5vi6A:
97.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		11 / 12 HIS A 142
HIS A 143
GLY A 151
PHE A 152
ASP A 178
HIS A 180
PHE A 208
ASP A 267
MET A 274
GLY A 304
TYR A 306
 None
EDO  A 410 (-4.4A)
EDO  A 410 ( 4.8A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
EDO  A 410 ( 3.7A)
ZN  A 401 (-2.4A)
EDO  A 407 (-4.1A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 0.37A 4qa0A-5vi6A:
63.7		 4qa0A-5vi6A:
97.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		3 / 3 PRO A 273
MET A 274
TYR A 306
 EDO  A 407 ( 3.6A)
EDO  A 407 (-4.1A)
EDO  A 407 ( 3.3A)
 0.48A 4qa0B-5vi6A:
63.8		 4qa0B-5vi6A:
97.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		3 / 3 PRO A 273
MET A 274
TYR A 306
 EDO  A 407 ( 3.6A)
EDO  A 407 (-4.1A)
EDO  A 407 ( 3.3A)
 0.45A 4qa0A-5vi6A:
63.7		 4qa0A-5vi6A:
97.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 11 HIS A 142
HIS A 143
ASP A 178
ASP A 267
GLY A 265
 None
EDO  A 410 (-4.4A)
ZN  A 401 ( 2.3A)
ZN  A 401 (-2.4A)
None
 1.35A 4qa0B-5vi6A:
63.8		 4qa0B-5vi6A:
97.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 11 HIS A 142
HIS A 143
PHE A 152
ASP A 178
GLY A 303
 None
EDO  A 410 (-4.4A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
None
 1.05A 4qa0B-5vi6A:
63.8		 4qa0B-5vi6A:
97.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		10 / 11 HIS A 142
HIS A 143
PHE A 152
ASP A 178
HIS A 180
PHE A 208
ASP A 267
MET A 274
GLY A 304
TYR A 306
 None
EDO  A 410 (-4.4A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
EDO  A 410 ( 3.7A)
ZN  A 401 (-2.4A)
EDO  A 407 (-4.1A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 0.39A 4qa0B-5vi6A:
63.8		 4qa0B-5vi6A:
97.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		6 / 11 HIS A 143
HIS A 180
ASP A 267
MET A 274
GLY A 304
TYR A 306
 EDO  A 410 (-4.4A)
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.4A)
EDO  A 407 (-4.1A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 1.15A 4qa0B-5vi6A:
63.8		 4qa0B-5vi6A:
97.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		6 / 12 HIS A 142
HIS A 143
GLY A 151
PHE A 152
ASP A 178
GLY A 303
 None
EDO  A 410 (-4.4A)
EDO  A 410 ( 4.8A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
None
 1.03A 4qa2A-5vi6A:
64.5		 4qa2A-5vi6A:
97.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		11 / 12 HIS A 142
HIS A 143
GLY A 151
PHE A 152
ASP A 178
HIS A 180
PHE A 208
ASP A 267
MET A 274
GLY A 304
TYR A 306
 None
EDO  A 410 (-4.4A)
EDO  A 410 ( 4.8A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
EDO  A 410 ( 3.7A)
ZN  A 401 (-2.4A)
EDO  A 407 (-4.1A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 0.32A 4qa2A-5vi6A:
64.5		 4qa2A-5vi6A:
97.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		6 / 12 HIS A 143
HIS A 180
ASP A 267
MET A 274
GLY A 304
TYR A 306
 EDO  A 410 (-4.4A)
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.4A)
EDO  A 407 (-4.1A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 1.14A 4qa2A-5vi6A:
64.5		 4qa2A-5vi6A:
97.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		3 / 3 PRO A 273
MET A 274
TYR A 306
 EDO  A 407 ( 3.6A)
EDO  A 407 (-4.1A)
EDO  A 407 ( 3.3A)
 0.46A 4qa2B-5vi6A:
64.1		 4qa2B-5vi6A:
97.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		6 / 12 HIS A 142
HIS A 143
ASP A 178
HIS A 180
ASP A 267
GLY A 265
 None
EDO  A 410 (-4.4A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.4A)
None
 1.31A 4qa2B-5vi6A:
64.1		 4qa2B-5vi6A:
97.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		6 / 12 HIS A 142
HIS A 143
GLY A 151
PHE A 152
ASP A 178
GLY A 303
 None
EDO  A 410 (-4.4A)
EDO  A 410 ( 4.8A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
None
 1.04A 4qa2B-5vi6A:
64.1		 4qa2B-5vi6A:
97.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		11 / 12 HIS A 142
HIS A 143
GLY A 151
PHE A 152
ASP A 178
HIS A 180
PHE A 208
ASP A 267
MET A 274
GLY A 304
TYR A 306
 None
EDO  A 410 (-4.4A)
EDO  A 410 ( 4.8A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
EDO  A 410 ( 3.7A)
ZN  A 401 (-2.4A)
EDO  A 407 (-4.1A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 0.34A 4qa2B-5vi6A:
64.1		 4qa2B-5vi6A:
97.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		6 / 12 HIS A 143
HIS A 180
ASP A 267
MET A 274
GLY A 304
TYR A 306
 EDO  A 410 (-4.4A)
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.4A)
EDO  A 407 (-4.1A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 1.15A 4qa2B-5vi6A:
64.1		 4qa2B-5vi6A:
97.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		4 / 6 LYS A  33
GLY A 304
GLY A 305
ASP A 267
 None
ZN  A 401 ( 4.2A)
None
ZN  A 401 (-2.4A)
 0.85A 5a06D-5vi6A:
undetectable		 5a06D-5vi6A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 12 GLY A 140
GLY A 303
GLY A 265
LEU A 264
LEU A 299
 None
 0.91A 5c0oF-5vi6A:
3.2		 5c0oF-5vi6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		4 / 4 LEU A 366
ILE A 362
PRO A 230
LEU A 200
 None
 1.04A 5eb3A-5vi6A:
undetectable		 5eb3A-5vi6A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		9 / 12 HIS A 142
HIS A 143
GLY A 151
PHE A 152
ASP A 178
HIS A 180
PHE A 208
ASP A 267
TYR A 306
 None
EDO  A 410 (-4.4A)
EDO  A 410 ( 4.8A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
EDO  A 410 ( 3.7A)
ZN  A 401 (-2.4A)
EDO  A 407 ( 3.3A)
 0.26A 5eeiA-5vi6A:
41.2		 5eeiA-5vi6A:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 12 SER A 150
HIS A 142
HIS A 180
ASP A 267
TYR A 306
 EDO  A 410 (-1.9A)
None
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.4A)
EDO  A 407 ( 3.3A)
 1.26A 5eeiA-5vi6A:
41.2		 5eeiA-5vi6A:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		9 / 12 HIS A 142
HIS A 143
GLY A 151
PHE A 152
ASP A 178
HIS A 180
PHE A 208
ASP A 267
TYR A 306
 None
EDO  A 410 (-4.4A)
EDO  A 410 ( 4.8A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
EDO  A 410 ( 3.7A)
ZN  A 401 (-2.4A)
EDO  A 407 ( 3.3A)
 0.26A 5eeiB-5vi6A:
41.3		 5eeiB-5vi6A:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 12 SER A 150
HIS A 142
HIS A 180
ASP A 267
TYR A 306
 EDO  A 410 (-1.9A)
None
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.4A)
EDO  A 407 ( 3.3A)
 1.25A 5eeiB-5vi6A:
41.3		 5eeiB-5vi6A:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 12 HIS A 142
ASP A 178
HIS A 180
ASP A 267
GLY A 265
 None
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.4A)
None
 1.25A 5eenA-5vi6A:
41.4		 5eenA-5vi6A:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 12 HIS A 142
HIS A 143
PHE A 152
ASP A 178
GLY A 303
 None
EDO  A 410 (-4.4A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
None
 0.99A 5eenA-5vi6A:
41.4		 5eenA-5vi6A:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		9 / 12 HIS A 142
HIS A 143
PHE A 152
ASP A 178
HIS A 180
PHE A 208
ASP A 267
GLY A 304
TYR A 306
 None
EDO  A 410 (-4.4A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
EDO  A 410 ( 3.7A)
ZN  A 401 (-2.4A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 0.34A 5eenA-5vi6A:
41.4		 5eenA-5vi6A:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		6 / 12 SER A 150
HIS A 142
HIS A 180
ASP A 267
GLY A 304
TYR A 306
 EDO  A 410 (-1.9A)
None
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.4A)
ZN  A 401 ( 4.2A)
EDO  A 407 ( 3.3A)
 1.19A 5eenA-5vi6A:
41.4		 5eenA-5vi6A:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		8 / 12 HIS A 142
HIS A 143
PHE A 152
ASP A 178
HIS A 180
PHE A 208
ASP A 267
TYR A 306
 None
EDO  A 410 (-4.4A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
EDO  A 410 ( 3.7A)
ZN  A 401 (-2.4A)
EDO  A 407 ( 3.3A)
 0.31A 5eenB-5vi6A:
41.4		 5eenB-5vi6A:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 12 SER A 150
HIS A 142
HIS A 180
ASP A 267
TYR A 306
 EDO  A 410 (-1.9A)
None
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.4A)
EDO  A 407 ( 3.3A)
 1.22A 5eenB-5vi6A:
41.4		 5eenB-5vi6A:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		8 / 12 HIS A 142
HIS A 143
PHE A 152
ASP A 178
HIS A 180
PHE A 208
ASP A 267
TYR A 306
 None
EDO  A 410 (-4.4A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
EDO  A 410 ( 3.7A)
ZN  A 401 (-2.4A)
EDO  A 407 ( 3.3A)
 0.36A 5ef8A-5vi6A:
41.0		 5ef8A-5vi6A:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 12 SER A 150
ASP A 178
HIS A 180
PHE A 208
ASP A 267
 EDO  A 410 (-1.9A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
EDO  A 410 ( 3.7A)
ZN  A 401 (-2.4A)
 1.44A 5ef8A-5vi6A:
41.0		 5ef8A-5vi6A:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		8 / 12 HIS A 142
HIS A 143
PHE A 152
ASP A 178
HIS A 180
PHE A 208
ASP A 267
TYR A 306
 None
EDO  A 410 (-4.4A)
EDO  A 407 (-4.2A)
ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.1A)
EDO  A 410 ( 3.7A)
ZN  A 401 (-2.4A)
EDO  A 407 ( 3.3A)
 0.32A 5ef8B-5vi6A:
41.2		 5ef8B-5vi6A:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		4 / 5 ALA A 122
GLY A 129
CYH A 131
LYS A 132
 None
 1.12A 5jliA-5vi6A:
undetectable		 5jliA-5vi6A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		4 / 5 ALA A 123
GLY A 129
CYH A 131
LYS A 132
 None
 1.25A 5jliA-5vi6A:
undetectable		 5jliA-5vi6A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		4 / 5 ALA A 122
GLY A 129
CYH A 131
LYS A 132
 None
 1.22A 5jt4A-5vi6A:
undetectable		 5jt4A-5vi6A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		4 / 5 ALA A 123
GLY A 129
CYH A 131
LYS A 132
 None
 1.30A 5jt4A-5vi6A:
undetectable		 5jt4A-5vi6A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		3 / 3 ARG A 353
ILE A 235
PHE A 277
 None
 0.67A 5kirA-5vi6A:
undetectable		 5kirA-5vi6A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		6 / 12 GLY A 140
ASP A 157
ASN A 156
ILE A 300
LEU A 299
LEU A 165
 None
 1.13A 5wy0A-5vi6A:
undetectable		 5wy0A-5vi6A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		4 / 5 VAL A 345
ARG A 313
GLY A 341
TYR A 340
 None
 1.39A 5x80A-5vi6A:
undetectable
5x80B-5vi6A:
undetectable		 5x80A-5vi6A:
18.38
5x80B-5vi6A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		4 / 5 GLY A 341
TYR A 340
VAL A 345
ARG A 313
 None
 1.39A 5x80C-5vi6A:
undetectable
5x80D-5vi6A:
undetectable		 5x80C-5vi6A:
18.38
5x80D-5vi6A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		3 / 3 HIS A 180
HIS A 143
HIS A 142
 ZN  A 401 ( 3.1A)
EDO  A 410 (-4.4A)
None
 0.77A 5z84N-5vi6A:
undetectable		 5z84N-5vi6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		3 / 3 HIS A 180
HIS A 143
HIS A 142
 ZN  A 401 ( 3.1A)
EDO  A 410 (-4.4A)
None
 0.79A 5z85A-5vi6A:
undetectable		 5z85A-5vi6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		3 / 3 HIS A 180
HIS A 143
HIS A 142
 ZN  A 401 ( 3.1A)
EDO  A 410 (-4.4A)
None
 0.73A 5z86A-5vi6A:
undetectable		 5z86A-5vi6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		3 / 3 HIS A 180
HIS A 143
HIS A 142
 ZN  A 401 ( 3.1A)
EDO  A 410 (-4.4A)
None
 0.75A 5z86N-5vi6A:
undetectable		 5z86N-5vi6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		3 / 3 HIS A 180
HIS A 143
HIS A 142
 ZN  A 401 ( 3.1A)
EDO  A 410 (-4.4A)
None
 0.78A 5zcpN-5vi6A:
undetectable		 5zcpN-5vi6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		3 / 3 HIS A 180
HIS A 143
HIS A 142
 ZN  A 401 ( 3.1A)
EDO  A 410 (-4.4A)
None
 0.77A 5zcqN-5vi6A:
undetectable		 5zcqN-5vi6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		3 / 3 TYR A 306
LEU A 179
ASP A 233
 EDO  A 407 ( 3.3A)
None
None
 0.71A 5zv2B-5vi6A:
undetectable		 5zv2B-5vi6A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		5 / 12 VAL A 175
ASP A 176
LEU A 292
THR A 319
GLY A 302
 None
K  A 402 (-3.4A)
None
None
None
 1.15A 6b0lB-5vi6A:
undetectable		 6b0lB-5vi6A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens) 		3 / 3 HIS A 180
HIS A 143
HIS A 142
 ZN  A 401 ( 3.1A)
EDO  A 410 (-4.4A)
None
 0.74A 6hu9a-5vi6A:
undetectable		 6hu9a-5vi6A:
22.04