SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5via'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 5via PSEUDOPEROXIDASE
(Leishmania
major) 		5 / 12 ILE A  85
TYR A 235
VAL A 208
GLY A 209
LEU A 230
 HEM  A 500 ( 3.9A)
None
None
HEM  A 500 (-3.1A)
None
 1.15A 2bxeB-5viaA:
undetectable		 2bxeB-5viaA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5via PSEUDOPEROXIDASE
(Leishmania
major) 		5 / 9 PHE A  74
LEU A 155
ALA A 140
LEU A 138
ALA A  70
 None
 1.28A 2vcvH-5viaA:
undetectable		 2vcvH-5viaA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5via PSEUDOPEROXIDASE
(Leishmania
major) 		4 / 8 ARG A 314
GLN A 316
PHE A 317
ASN A 232
 None
 1.29A 3n66B-5viaA:
undetectable		 3n66B-5viaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5via PSEUDOPEROXIDASE
(Leishmania
major) 		3 / 3 ASP A 104
ARG A 252
THR A 265
 None
 0.77A 4i13A-5viaA:
undetectable		 4i13A-5viaA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 5via PSEUDOPEROXIDASE
(Leishmania
major) 		4 / 6 ILE A  85
ILE A 325
PHE A 317
LEU A 202
 HEM  A 500 ( 3.9A)
None
None
HEM  A 500 (-4.1A)
 0.95A 4m51A-5viaA:
undetectable		 4m51A-5viaA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5via PSEUDOPEROXIDASE
(Leishmania
major) 		3 / 3 ASP A 104
ARG A 252
THR A 265
 None
 0.77A 4p3rA-5viaA:
undetectable		 4p3rA-5viaA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 5via PSEUDOPEROXIDASE
(Leishmania
major) 		3 / 3 PRO A  59
LEU A 332
SER A 336
 None
 0.76A 5fsaB-5viaA:
undetectable		 5fsaB-5viaA:
20.17