SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vis'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		4 / 7 PHE A 183
SER A 186
SER A  55
PHE A 141
 None
 1.17A 1fxvA-5visA:
undetectable
1fxvB-5visA:
undetectable		 1fxvA-5visA:
23.79
1fxvB-5visA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		4 / 8 ARG A 249
SER A 211
ASN A  11
ASP A  86
 None
 1.21A 1hwiB-5visA:
undetectable		 1hwiB-5visA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		5 / 11 ALA A  81
ILE A  74
LEU A  37
LEU A  36
ALA A  33
 None
 1.24A 3kw2A-5visA:
undetectable		 3kw2A-5visA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		5 / 11 ALA A  81
ILE A  74
LEU A  37
LEU A  36
ALA A  33
 None
 1.21A 3kw2B-5visA:
undetectable		 3kw2B-5visA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		5 / 9 GLY A  40
ALA A  41
ASP A  42
ILE A  43
LEU A  36
 None
 0.76A 3ogpA-5visA:
undetectable		 3ogpA-5visA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		5 / 9 GLY A  40
ALA A  41
ASP A  42
ILE A  43
LEU A  36
 None
 0.82A 3ogpB-5visA:
undetectable		 3ogpB-5visA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		5 / 12 GLY A  40
ALA A  41
ASP A  42
ILE A  43
LEU A  36
 None
 0.79A 3ogqB-5visA:
undetectable		 3ogqB-5visA:
17.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		3 / 3 PHE A 183
LYS A 215
SER A 216
 None
 0.71A 3tyeB-5visA:
33.3		 3tyeB-5visA:
34.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		5 / 8 PRO A  53
GLY A 181
PHE A 183
LYS A 215
SER A 216
 None
 1.06A 3tzfB-5visA:
34.2		 3tzfB-5visA:
34.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		5 / 8 THR A  51
PRO A  53
PHE A 183
LYS A 215
SER A 216
 None
 0.96A 3tzfB-5visA:
34.2		 3tzfB-5visA:
34.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		4 / 5 GLY A 179
THR A 139
VAL A 107
ASP A 177
 None
 1.09A 4eohA-5visA:
undetectable		 4eohA-5visA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		4 / 7 ASP A 106
ASP A  86
ASP A 136
GLU A  63
 None
 1.19A 4feuB-5visA:
undetectable		 4feuB-5visA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		4 / 8 ASP A 106
ASP A  86
ASP A 136
GLU A  63
 None
 1.17A 4feuF-5visA:
undetectable		 4feuF-5visA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		4 / 7 ASP A 106
ASP A  86
ASP A 136
GLU A  63
 None
 1.18A 4fevB-5visA:
undetectable		 4fevB-5visA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		4 / 7 ASP A 106
ASP A  86
ASP A 136
GLU A  63
 None
 1.19A 4fevF-5visA:
undetectable		 4fevF-5visA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		4 / 7 ASP A 106
ASP A  86
ASP A 136
GLU A  63
 None
 1.12A 4fewB-5visA:
undetectable		 4fewB-5visA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		4 / 8 ASP A 106
ASP A  86
ASP A 136
GLU A  63
 None
 1.21A 4fewD-5visA:
undetectable		 4fewD-5visA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		4 / 7 ASP A 106
ASP A  86
ASP A 136
GLU A  63
 None
 1.16A 4fexB-5visA:
undetectable		 4fexB-5visA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		4 / 8 ASP A 106
ASP A  86
ASP A 136
GLU A  63
 None
 1.19A 4gkhB-5visA:
undetectable		 4gkhB-5visA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		4 / 8 ASP A 106
ASP A  86
ASP A 136
GLU A  63
 None
 1.17A 4gkhD-5visA:
undetectable		 4gkhD-5visA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		4 / 8 ASP A 106
ASP A  86
ASP A 136
GLU A  63
 None
 1.22A 4gkiA-5visA:
undetectable		 4gkiA-5visA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		4 / 6 ILE A 248
SER A 237
PHE A 217
LEU A 195
 None
 0.98A 4m51A-5visA:
5.9		 4m51A-5visA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		5 / 12 VAL A 107
PHE A 183
SER A 211
GLY A 179
THR A  51
 None
 1.30A 4mm4B-5visA:
undetectable		 4mm4B-5visA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		5 / 9 ALA A 101
ALA A  96
ALA A  93
ALA A 125
SER A 123
 None
 1.05A 4twdA-5visA:
undetectable
4twdB-5visA:
undetectable
4twdC-5visA:
undetectable
4twdD-5visA:
undetectable
4twdE-5visA:
undetectable		 4twdA-5visA:
21.52
4twdB-5visA:
21.52
4twdC-5visA:
21.52
4twdD-5visA:
21.52
4twdE-5visA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		5 / 11 PHE A 183
ASP A 134
GLY A  52
SER A 132
GLY A 179
 None
 1.25A 4xnxA-5visA:
undetectable		 4xnxA-5visA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		4 / 4 PHE A 183
ASP A 134
GLY A  52
SER A 132
 None
 1.20A 4xp9C-5visA:
undetectable		 4xp9C-5visA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		5 / 10 PHE A 183
ASP A 134
GLY A  52
SER A 132
GLY A 179
 None
 1.37A 4xpbA-5visA:
0.9		 4xpbA-5visA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		5 / 10 PHE A 183
ASP A 134
TYR A 146
SER A 132
GLY A 179
 None
 1.48A 4xpbA-5visA:
0.9		 4xpbA-5visA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		5 / 12 PRO A 212
LEU A 195
VAL A 150
PHE A 201
LEU A 198
 None
 1.34A 5cymA-5visA:
1.6		 5cymA-5visA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		4 / 7 ILE A   6
THR A 233
ILE A 234
SER A 237
 None
 0.62A 5fukA-5visA:
undetectable
5fukB-5visA:
undetectable		 5fukA-5visA:
21.84
5fukB-5visA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5vis DIHYDROPTEROATE
SYNTHASE
(soil
metagenome) 		4 / 5 PRO A 170
GLY A 168
VAL A 120
ARG A 173
 None
 1.43A 5x80C-5visA:
undetectable
5x80D-5visA:
undetectable		 5x80C-5visA:
19.84
5x80D-5visA:
19.84