SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vix'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 5vix POLYUBIQUITIN
(Naegleria
gruberi) 		5 / 12 ILE A   3
THR A   7
PHE A  45
LEU A  43
ILE A  30
 None
 1.01A 2cd2A-5vixA:
undetectable		 2cd2A-5vixA:
21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FCN_A_DVAA35_0
(UBIQUITIN)		 5vix POLYUBIQUITIN
(Naegleria
gruberi) 		4 / 4 GLN A  31
GLU A  34
ILE A  36
PRO A  37
 None
 0.88A 2fcnA-5vixA:
16.1		 2fcnA-5vixA:
90.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FCN_A_DVAA35_0
(UBIQUITIN)		 5vix POLYUBIQUITIN
(Naegleria
gruberi) 		4 / 4 GLN A 107
GLU A 110
ILE A 112
PRO A 113
 None
 0.91A 2fcnA-5vixA:
16.1		 2fcnA-5vixA:
90.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FCN_B_DVAB35_0
(UBIQUITIN)		 5vix POLYUBIQUITIN
(Naegleria
gruberi) 		4 / 6 GLN A  31
GLU A  34
ILE A  36
PRO A  37
 None
 0.34A 2fcnA-5vixA:
16.1
2fcnB-5vixA:
15.8		 2fcnA-5vixA:
90.00
2fcnB-5vixA:
90.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FCN_B_DVAB35_0
(UBIQUITIN)		 5vix POLYUBIQUITIN
(Naegleria
gruberi) 		4 / 6 GLN A 107
GLU A 110
ILE A 112
PRO A 113
 None
 0.42A 2fcnA-5vixA:
16.1
2fcnB-5vixA:
15.8		 2fcnA-5vixA:
90.00
2fcnB-5vixA:
90.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5vix POLYUBIQUITIN
(Naegleria
gruberi) 		4 / 7 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.85A 4w5oA-5vixA:
undetectable		 4w5oA-5vixA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5vix POLYUBIQUITIN
(Naegleria
gruberi) 		4 / 7 ILE A 120
GLN A 125
ILE A  99
ASP A 128
 NO3  A 201 (-4.5A)
None
None
None
 0.72A 4w5oA-5vixA:
undetectable		 4w5oA-5vixA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5vix POLYUBIQUITIN
(Naegleria
gruberi) 		4 / 6 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.78A 4w5qA-5vixA:
undetectable		 4w5qA-5vixA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5vix POLYUBIQUITIN
(Naegleria
gruberi) 		4 / 6 ILE A 120
GLN A 125
ILE A  99
ASP A 128
 NO3  A 201 (-4.5A)
None
None
None
 0.68A 4w5qA-5vixA:
undetectable		 4w5qA-5vixA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5vix POLYUBIQUITIN
(Naegleria
gruberi) 		4 / 6 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.83A 4w5tA-5vixA:
undetectable		 4w5tA-5vixA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5vix POLYUBIQUITIN
(Naegleria
gruberi) 		4 / 6 ILE A 120
GLN A 125
ILE A  99
ASP A 128
 NO3  A 201 (-4.5A)
None
None
None
 0.76A 4w5tA-5vixA:
undetectable		 4w5tA-5vixA:
13.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 5vix POLYUBIQUITIN
(Naegleria
gruberi) 		4 / 4 LEU A   8
ILE A  44
HIS A  68
VAL A  70
 None
None
None
NO3  A 203 (-4.2A)
 0.97A 4xyzA-5vixA:
15.9		 4xyzA-5vixA:
96.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 5vix POLYUBIQUITIN
(Naegleria
gruberi) 		4 / 4 LEU A  84
ILE A 120
HIS A 144
VAL A 146
 None
NO3  A 201 (-4.5A)
NO3  A 201 (-3.6A)
None
 0.70A 4xyzA-5vixA:
15.9		 4xyzA-5vixA:
96.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5vix POLYUBIQUITIN
(Naegleria
gruberi) 		4 / 6 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.74A 4z4cA-5vixA:
undetectable		 4z4cA-5vixA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5vix POLYUBIQUITIN
(Naegleria
gruberi) 		4 / 6 ILE A 120
GLN A 125
ILE A  99
ASP A 128
 NO3  A 201 (-4.5A)
None
None
None
 0.74A 4z4cA-5vixA:
undetectable		 4z4cA-5vixA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5vix POLYUBIQUITIN
(Naegleria
gruberi) 		4 / 6 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.82A 4z4dA-5vixA:
undetectable		 4z4dA-5vixA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5vix POLYUBIQUITIN
(Naegleria
gruberi) 		4 / 6 ILE A 120
GLN A 125
ILE A  99
ASP A 128
 NO3  A 201 (-4.5A)
None
None
None
 0.71A 4z4dA-5vixA:
undetectable		 4z4dA-5vixA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5vix POLYUBIQUITIN
(Naegleria
gruberi) 		4 / 7 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.82A 4z4eA-5vixA:
undetectable		 4z4eA-5vixA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5vix POLYUBIQUITIN
(Naegleria
gruberi) 		4 / 7 ILE A 120
GLN A 125
ILE A  99
ASP A 128
 NO3  A 201 (-4.5A)
None
None
None
 0.68A 4z4eA-5vixA:
undetectable		 4z4eA-5vixA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5vix POLYUBIQUITIN
(Naegleria
gruberi) 		4 / 7 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.83A 4z4gA-5vixA:
undetectable		 4z4gA-5vixA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5vix POLYUBIQUITIN
(Naegleria
gruberi) 		4 / 7 ILE A 120
GLN A 125
ILE A  99
ASP A 128
 NO3  A 201 (-4.5A)
None
None
None
 0.70A 4z4gA-5vixA:
undetectable		 4z4gA-5vixA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 5vix POLYUBIQUITIN
(Naegleria
gruberi) 		4 / 6 ILE A 120
GLN A 125
ILE A  99
ASP A 128
 NO3  A 201 (-4.5A)
None
None
None
 0.72A 6cbdA-5vixA:
undetectable		 6cbdA-5vixA:
13.08