SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5viy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 5viy 8ANC195 G52K5 FAB
HEAVY CHAIN
(Homo
sapiens) 		4 / 4 ALA K  40
ARG K  38
GLN K  43
GLU K  46
 None
 0.87A 1lqtB-5viyK:
undetectable		 1lqtB-5viyK:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 5viy 8ANC195 G52K5 FAB
HEAVY CHAIN
(Homo
sapiens) 		4 / 4 ALA K  40
ARG K  38
GLN K  43
GLU K  46
 None
 0.90A 1lquB-5viyK:
undetectable		 1lquB-5viyK:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5viy BG1 FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 10 TYR H 165
HIS H 220
PHE H 166
LEU H  11
GLY H  94
 None
 1.44A 1uhoA-5viyH:
undetectable		 1uhoA-5viyH:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 5viy BG1 FAB HEAVY CHAIN
(Homo
sapiens) 		3 / 3 ALA H  99
VAL H  37
TRP H  47
 None
 0.91A 1w5uA-5viyH:
undetectable
1w5uB-5viyH:
undetectable		 1w5uA-5viyH:
9.38
1w5uB-5viyH:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 5viy BG1 FAB LIGHT CHAIN
(Homo
sapiens) 		4 / 5 LYS G 149
SER G 177
LEU G 154
SER G 156
 None
 1.49A 3iluH-5viyG:
undetectable		 3iluH-5viyG:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 5viy 8ANC195 G52K5 FAB
HEAVY CHAIN
(Homo
sapiens) 		3 / 3 PRO K  14
SER K  84
ASN K  82
 None
 0.89A 3lslG-5viyK:
undetectable		 3lslG-5viyK:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5viy BG1 FAB HEAVY CHAIN
(Homo
sapiens) 		3 / 3 PHE H 114
GLN H 111
PHE H  50
 None
 0.47A 3rv5A-5viyH:
undetectable		 3rv5A-5viyH:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 5viy BG1 FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 11 VAL H  85
VAL H 129
GLY H  94
ALA H  40
LEU H  18
 None
 0.82A 3sm2B-5viyH:
undetectable		 3sm2B-5viyH:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 5viy 8ANC195 G52K5 FAB
HEAVY CHAIN
(Homo
sapiens) 		4 / 7 GLU K  10
SER K  79
ASP K  73
THR K  75
 None
 1.30A 4uacA-5viyK:
undetectable		 4uacA-5viyK:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 5viy BG1 FAB HEAVY CHAIN
BG1 FAB LIGHT CHAIN
(Homo
sapiens) 		5 / 12 SER H 181
HIS H 184
GLY H 182
ASP G 167
ASP G 170
 None
 1.42A 5eeiA-5viyH:
undetectable		 5eeiA-5viyH:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 5viy BG1 FAB HEAVY CHAIN
BG1 FAB LIGHT CHAIN
(Homo
sapiens) 		5 / 12 SER H 181
HIS H 184
GLY H 182
ASP G 167
ASP G 170
 None
 1.43A 5eeiB-5viyH:
undetectable		 5eeiB-5viyH:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 5viy BG1 FAB LIGHT CHAIN
BG1 FAB HEAVY CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU H 144
THR G 178
GLY H 159
VAL H 202
LEU H 161
 None
 1.24A 5jo9A-5viyH:
undetectable		 5jo9A-5viyH:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 5viy BG1 FAB LIGHT CHAIN
(Homo
sapiens) 		3 / 3 THR G  20
SER G  74
TYR G  65
 None
 0.88A 5jseA-5viyG:
2.4		 5jseA-5viyG:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 5viy BG1 FAB LIGHT CHAIN
(Homo
sapiens) 		3 / 3 THR G  20
SER G  74
TYR G  65
 None
 0.88A 5jseB-5viyG:
undetectable		 5jseB-5viyG:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 5viy BG1 FAB LIGHT CHAIN
(Homo
sapiens) 		3 / 3 THR G  20
SER G  74
TYR G  65
 None
 0.88A 5jseC-5viyG:
undetectable		 5jseC-5viyG:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 5viy 8ANC195 G52K5 FAB
HEAVY CHAIN
(Homo
sapiens) 		4 / 5 PHE K  91
PHE K 100
LEU K  45
LEU K  80
 None
 1.08A 5veuH-5viyK:
undetectable		 5veuH-5viyK:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 5viy BG1 FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 7 SER H  23
SER H   7
GLY H   8
ARG H 125
 None
 1.12A 6btxA-5viyH:
undetectable		 6btxA-5viyH:
19.55