SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vj1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 300
GLY A 304
LEU A 270
GLU A 269
LEU A 297
 None
 1.25A 1cmcA-5vj1A:
undetectable
1cmcB-5vj1A:
undetectable		 1cmcA-5vj1A:
12.33
1cmcB-5vj1A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 270
GLU A 269
LEU A 297
ALA A 300
GLY A 304
 None
 1.26A 1cmcA-5vj1A:
undetectable
1cmcB-5vj1A:
undetectable		 1cmcA-5vj1A:
12.33
1cmcB-5vj1A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		4 / 6 ILE A 222
VAL A  53
ILE A 187
ILE A  47
 None
 0.64A 1uwhA-5vj1A:
undetectable		 1uwhA-5vj1A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		4 / 6 ILE A 356
GLY A 357
ALA A 358
HIS A 259
 None
 0.82A 1wmqA-5vj1A:
undetectable		 1wmqA-5vj1A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		4 / 6 ILE A 356
GLY A 357
ALA A 358
HIS A 259
 None
 0.85A 1wmqB-5vj1A:
undetectable		 1wmqB-5vj1A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		4 / 6 ILE A 356
GLY A 357
ALA A 358
HIS A 259
 None
 0.84A 1wpuA-5vj1A:
undetectable		 1wpuA-5vj1A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		4 / 6 ILE A 356
GLY A 357
ALA A 358
HIS A 259
 None
 0.84A 1wpuB-5vj1A:
undetectable		 1wpuB-5vj1A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		4 / 6 ILE A 356
GLY A 357
ALA A 358
HIS A 259
 None
 0.81A 1wrqA-5vj1A:
undetectable		 1wrqA-5vj1A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		4 / 6 ILE A 356
GLY A 357
ALA A 358
HIS A 259
 None
 0.81A 1wrqB-5vj1A:
undetectable		 1wrqB-5vj1A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 488
GLY A 494
GLY A 489
ALA A 486
THR A 502
 None
 1.16A 2c49A-5vj1A:
undetectable		 2c49A-5vj1A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1498_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		4 / 5 PHE A  97
HIS A  93
MET A  85
MET A  83
 None
 1.34A 2jc9A-5vj1A:
2.2		 2jc9A-5vj1A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 239
MET A 243
LEU A 463
GLU A 466
 None
 1.21A 2kuhA-5vj1A:
undetectable		 2kuhA-5vj1A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 12 VAL A  40
ALA A  42
LEU A 151
SER A  67
LEU A  96
 None
 1.20A 2oipC-5vj1A:
undetectable		 2oipC-5vj1A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		4 / 4 SER A 491
GLY A 494
HIS A 367
ASP A 458
 None
 1.32A 2oxtC-5vj1A:
undetectable		 2oxtC-5vj1A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		4 / 6 MET A 318
ILE A 301
PRO A 167
SER A 168
 None
 1.50A 2qd3B-5vj1A:
undetectable		 2qd3B-5vj1A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		4 / 9 ILE A  47
ALA A 150
VAL A 149
LYS A  18
 None
 1.05A 2vufB-5vj1A:
undetectable		 2vufB-5vj1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		4 / 8 GLN A  60
PHE A 312
GLY A 313
GLY A 380
 None
CL  A 601 (-3.6A)
None
None
 0.90A 2y6rB-5vj1A:
undetectable		 2y6rB-5vj1A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 12 MET A 420
ILE A 268
ALA A 266
THR A 296
LEU A 291
 None
 1.18A 3a50A-5vj1A:
undetectable		 3a50A-5vj1A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 337
TRP A 289
TYR A 321
 None
 0.92A 3aicA-5vj1A:
undetectable		 3aicA-5vj1A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 337
TRP A 289
TYR A 321
 None
 0.95A 3aicB-5vj1A:
undetectable		 3aicB-5vj1A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 337
TRP A 289
TYR A 321
 None
 0.96A 3aicE-5vj1A:
undetectable		 3aicE-5vj1A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 337
TRP A 289
TYR A 321
 None
 0.93A 3aicF-5vj1A:
undetectable		 3aicF-5vj1A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 337
TRP A 289
TYR A 321
 None
 0.96A 3aicG-5vj1A:
undetectable		 3aicG-5vj1A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 337
TRP A 289
TYR A 321
 None
 0.98A 3aicH-5vj1A:
undetectable		 3aicH-5vj1A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA1_0
(FERROCHELATASE)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 11 MET A 420
ILE A 233
HIS A 259
VAL A 254
TRP A 289
 None
 1.49A 3aqiA-5vj1A:
undetectable		 3aqiA-5vj1A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		4 / 8 ILE A 222
PRO A 295
HIS A 294
GLY A 313
 None
 0.86A 3em0B-5vj1A:
undetectable		 3em0B-5vj1A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 348
LEU A 291
LEU A 257
SER A 256
GLY A 386
 None
 0.98A 3g2oA-5vj1A:
2.0		 3g2oA-5vj1A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 12 VAL A  40
ALA A  42
LEU A 151
SER A  67
LEU A  96
 None
 1.17A 3hj3C-5vj1A:
undetectable		 3hj3C-5vj1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 5vj1 MDCC
(Pseudomonas
protegens) 		4 / 8 GLY C  21
PHE C  63
GLY C  92
PHE C  93
 None
 0.80A 3ko0O-5vj1C:
undetectable
3ko0Q-5vj1C:
undetectable		 3ko0O-5vj1C:
22.02
3ko0Q-5vj1C:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 11 VAL A 417
PHE A 226
GLY A 381
GLY A 380
ASN A  59
 None
None
None
None
CL  A 601 (-4.4A)
 1.39A 3owxA-5vj1A:
undetectable
3owxB-5vj1A:
2.8		 3owxA-5vj1A:
19.41
3owxB-5vj1A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 5vj1 MDCA
MDCC
(Pseudomonas
aeruginosa;
Pseudomonas
protegens) 		4 / 5 GLY C  79
ASP C  77
ARG C  54
MET A 240
 None
 1.44A 3qx3A-5vj1C:
undetectable		 3qx3A-5vj1C:
8.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 11 ASN A 148
ILE A 146
ARG A  14
GLY A 184
VAL A 152
 None
 1.20A 3rukD-5vj1A:
undetectable		 3rukD-5vj1A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		6 / 12 ASP A 457
ASP A 458
VAL A 417
ILE A 454
GLY A 366
ILE A 484
 None
 1.42A 3spkB-5vj1A:
undetectable		 3spkB-5vj1A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		4 / 7 ASN A 264
PHE A 263
ALA A 266
LEU A 529
 None
 1.10A 3t3sC-5vj1A:
undetectable		 3t3sC-5vj1A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 312
ASN A  58
GLY A 313
ALA A 382
GLY A 380
 CL  A 601 (-3.6A)
None
None
None
None
 1.28A 3v3oB-5vj1A:
undetectable		 3v3oB-5vj1A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 171
GLY A  57
LEU A 175
GLU A 170
 None
 1.07A 3w9tB-5vj1A:
undetectable		 3w9tB-5vj1A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 171
GLY A  57
LEU A 175
GLU A 170
 None
 1.06A 3w9tE-5vj1A:
undetectable		 3w9tE-5vj1A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 171
GLY A  57
LEU A 175
GLU A 170
 None
 1.08A 3w9tF-5vj1A:
undetectable		 3w9tF-5vj1A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 381
PHE A 312
ASN A 292
SER A 108
GLY A 380
 None
CL  A 601 (-3.6A)
CL  A 601 ( 4.3A)
None
None
 1.24A 3ztvA-5vj1A:
undetectable		 3ztvA-5vj1A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5vj1 MDCA
MDCC
(Pseudomonas
aeruginosa;
Pseudomonas
protegens) 		5 / 12 PRO A 430
PHE A 424
PRO C  82
LEU C  58
ALA A 488
 None
 1.49A 4a84A-5vj1A:
undetectable		 4a84A-5vj1A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 9 THR A 445
LEU A 126
LEU A 121
GLY A 118
VAL A 441
 None
 1.36A 4c9kB-5vj1A:
undetectable		 4c9kB-5vj1A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 9 THR A 445
LEU A 126
LEU A 121
GLY A 118
VAL A 441
 None
 1.36A 4c9pA-5vj1A:
undetectable		 4c9pA-5vj1A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 11 VAL A  40
ALA A  42
SER A  67
LEU A  96
VAL A  73
 None
 1.31A 4eilA-5vj1A:
undetectable		 4eilA-5vj1A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 11 VAL A  40
ALA A  42
SER A  67
LEU A  96
VAL A  73
 None
 1.30A 4eilE-5vj1A:
2.0		 4eilE-5vj1A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 5vj1 MDCA
MDCC
(Pseudomonas
aeruginosa;
Pseudomonas
protegens) 		4 / 7 ALA A 524
GLU C  90
LEU C  87
LEU A 239
 None
 0.94A 4iomA-5vj1A:
undetectable		 4iomA-5vj1A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 204
PRO A 201
ASP A 334
SER A 336
 None
 1.20A 4k7gB-5vj1A:
undetectable		 4k7gB-5vj1A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 11 VAL A  40
ALA A  42
SER A  67
LEU A  96
VAL A  73
 None
 1.32A 4kyaA-5vj1A:
2.1		 4kyaA-5vj1A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 12 VAL A  40
ALA A  42
SER A  67
LEU A  96
VAL A  73
 None
 1.35A 4kyaB-5vj1A:
undetectable		 4kyaB-5vj1A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 10 VAL A  40
ALA A  42
SER A  67
LEU A  96
VAL A  73
 None
 1.34A 4kyaC-5vj1A:
undetectable		 4kyaC-5vj1A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 12 VAL A  40
ALA A  42
SER A  67
LEU A  96
VAL A  73
 None
 1.34A 4kyaD-5vj1A:
undetectable		 4kyaD-5vj1A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 11 VAL A  40
ALA A  42
SER A  67
LEU A  96
VAL A  73
 None
 1.33A 4kyaE-5vj1A:
undetectable		 4kyaE-5vj1A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 12 VAL A  40
ALA A  42
SER A  67
LEU A  96
VAL A  73
 None
 1.33A 4kyaF-5vj1A:
undetectable		 4kyaF-5vj1A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 11 VAL A  40
ALA A  42
SER A  67
LEU A  96
VAL A  73
 None
 1.33A 4kyaG-5vj1A:
2.1		 4kyaG-5vj1A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 12 VAL A  40
ALA A  42
LEU A 151
SER A  67
LEU A  96
 None
 1.18A 4q0dA-5vj1A:
undetectable		 4q0dA-5vj1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 12 VAL A  40
ALA A  42
LEU A 151
SER A  67
LEU A  96
 None
 1.18A 4q0dB-5vj1A:
undetectable		 4q0dB-5vj1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 12 VAL A  40
ALA A  42
LEU A 151
SER A  67
LEU A  96
 None
 1.18A 4q0dE-5vj1A:
undetectable		 4q0dE-5vj1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		4 / 5 GLY A 313
THR A 314
GLY A 166
GLU A 170
 None
 1.05A 4v20A-5vj1A:
undetectable		 4v20A-5vj1A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 11 VAL A 417
PHE A 226
GLY A 381
GLY A 380
ASN A  59
 None
None
None
None
CL  A 601 (-4.4A)
 1.40A 4zvmA-5vj1A:
undetectable
4zvmB-5vj1A:
2.1		 4zvmA-5vj1A:
20.27
4zvmB-5vj1A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5vj1 MDCA
MDCC
(Pseudomonas
aeruginosa;
Pseudomonas
protegens) 		4 / 6 ARG C  86
GLY C  83
GLU A 466
ARG C  88
 None
 1.06A 5btaA-5vj1C:
undetectable
5btaB-5vj1C:
undetectable
5btaC-5vj1C:
undetectable		 5btaA-5vj1C:
11.13
5btaB-5vj1C:
18.03
5btaC-5vj1C:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5vj1 MDCA
MDCC
(Pseudomonas
aeruginosa;
Pseudomonas
protegens) 		4 / 5 ARG C  86
GLY C  83
GLU A 466
ARG C  88
 None
 1.14A 5cdqR-5vj1C:
undetectable
5cdqS-5vj1C:
undetectable
5cdqT-5vj1C:
undetectable		 5cdqR-5vj1C:
12.45
5cdqS-5vj1C:
20.77
5cdqT-5vj1C:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 309
PRO A 299
ALA A 300
VAL A 306
LEU A 257
 None
 1.06A 5hv1A-5vj1A:
5.2		 5hv1A-5vj1A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		3 / 3 GLY A 386
GLN A 419
LYS A 415
 None
 0.83A 5imsB-5vj1A:
undetectable		 5imsB-5vj1A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		4 / 5 ILE A 268
LEU A 517
HIS A 461
VAL A 418
 None
 1.00A 5jmnB-5vj1A:
undetectable		 5jmnB-5vj1A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 5vj1 MDCA
MDCC
(Pseudomonas
aeruginosa;
Pseudomonas
protegens) 		4 / 6 ARG C  86
GLY C  83
THR A 423
GLU A 466
 None
 1.01A 5ny7A-5vj1C:
undetectable		 5ny7A-5vj1C:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 509
VAL A 418
LEU A 416
GLY A 247
ILE A 468
 None
 0.93A 5vopB-5vj1A:
2.4		 5vopB-5vj1A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 306
TYR A 321
ILE A 301
GLU A 302
 None
 0.99A 5z3jA-5vj1A:
undetectable		 5z3jA-5vj1A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)		 5vj1 MDCA
(Pseudomonas
aeruginosa) 		6 / 12 ASP A 457
ASP A 458
VAL A 417
ILE A 454
GLY A 366
ILE A 484
 None
 1.42A 6dilA-5vj1A:
undetectable		 6dilA-5vj1A:
10.87