SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vj7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 THR A 168
ALA A 171
ASP A 172
LEU A 211
ILE A 206
 None
 1.15A 1errA-5vj7A:
undetectable		 1errA-5vj7A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5vj7 FERREDOXIN-NADP(+)
REDUCTASE SUBUNIT
ALPHA
(Pyrococcus
furiosus) 		5 / 12 GLY B 110
GLU B 113
GLY B 196
VAL B 112
ARG B  66
 None
FAD  B 301 (-3.3A)
None
None
FAD  B 301 (-2.8A)
 1.28A 1n2xA-5vj7B:
5.9		 1n2xA-5vj7B:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 245
GLY A 246
GLY A 163
ILE A 159
ALA A 456
 None
None
FAD  A 503 (-3.4A)
None
FAD  A 503 (-2.7A)
 0.94A 1nv8B-5vj7A:
3.5		 1nv8B-5vj7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 11 GLY A 302
ALA A 301
ILE A 334
VAL A 345
ILE A 321
 None
 0.86A 1ohrA-5vj7A:
undetectable		 1ohrA-5vj7A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 5vj7 FERREDOXIN-NADP(+)
REDUCTASE SUBUNIT
ALPHA
OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 11 ILE A 226
THR B  48
PRO B  49
THR A 232
ALA A 415
 None
FAD  B 301 (-3.4A)
None
None
None
 0.91A 1rv7A-5vj7A:
undetectable
1rv7B-5vj7A:
undetectable		 1rv7A-5vj7A:
13.56
1rv7B-5vj7A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 ASP A 172
MET A 457
ASP A 445
ILE A 454
THR A 168
 None
None
FAD  A 503 (-2.0A)
SF4  A 501 ( 4.3A)
None
 1.35A 1s14A-5vj7A:
undetectable		 1s14A-5vj7A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 10 ILE A 122
GLY A 123
GLY A  98
VAL A  58
ILE A  60
 SF4  A 501 ( 4.7A)
SF4  A 501 ( 4.3A)
SF4  A 501 ( 4.4A)
None
SF4  A 501 ( 4.6A)
 0.85A 1sdtA-5vj7A:
undetectable		 1sdtA-5vj7A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 245
GLY A 246
GLY A 163
ILE A 159
ALA A 456
 None
None
FAD  A 503 (-3.4A)
None
FAD  A 503 (-2.7A)
 0.97A 1sg9B-5vj7A:
3.0		 1sg9B-5vj7A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 10 GLY A 264
ILE A 357
GLY A 259
ILE A 260
PRO A 353
 None
 0.93A 1sh9B-5vj7A:
undetectable		 1sh9B-5vj7A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 245
GLY A 246
GLY A 163
ILE A 159
ALA A 456
 None
None
FAD  A 503 (-3.4A)
None
FAD  A 503 (-2.7A)
 0.99A 1vq1B-5vj7A:
3.0		 1vq1B-5vj7A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		4 / 6 LEU A 207
GLY A 190
LEU A 167
ILE A 221
 None
 0.97A 1yajF-5vj7A:
undetectable		 1yajF-5vj7A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 264
ILE A 357
GLY A 259
ILE A 260
PRO A 353
 None
 0.99A 2b7zA-5vj7A:
undetectable		 2b7zA-5vj7A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 11 PHE A 271
ILE A 275
THR A 304
ALA A 305
VAL A 292
 None
None
FAD  A 503 (-2.0A)
None
None
 1.37A 2gl0B-5vj7A:
undetectable
2gl0C-5vj7A:
undetectable		 2gl0B-5vj7A:
18.49
2gl0C-5vj7A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 275
THR A 304
ALA A 305
VAL A 292
PHE A 271
 None
FAD  A 503 (-2.0A)
None
None
None
 1.31A 2gl0A-5vj7A:
undetectable
2gl0C-5vj7A:
undetectable		 2gl0A-5vj7A:
18.49
2gl0C-5vj7A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 PHE A 271
ILE A 275
THR A 304
ALA A 305
VAL A 292
 None
None
FAD  A 503 (-2.0A)
None
None
 1.34A 2gl0D-5vj7A:
undetectable
2gl0E-5vj7A:
undetectable		 2gl0D-5vj7A:
18.49
2gl0E-5vj7A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_E_ADNE905_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 11 PHE A 271
ILE A 275
THR A 304
ALA A 305
VAL A 292
 None
None
FAD  A 503 (-2.0A)
None
None
 1.35A 2gl0E-5vj7A:
undetectable
2gl0F-5vj7A:
undetectable		 2gl0E-5vj7A:
18.49
2gl0F-5vj7A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_F_ADNF906_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 11 ILE A 275
THR A 304
ALA A 305
VAL A 292
PHE A 271
 None
FAD  A 503 (-2.0A)
None
None
None
 1.33A 2gl0D-5vj7A:
undetectable
2gl0F-5vj7A:
undetectable		 2gl0D-5vj7A:
18.49
2gl0F-5vj7A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 264
ILE A 357
GLY A 259
ILE A 260
PRO A 353
 None
 0.86A 2nmyB-5vj7A:
undetectable		 2nmyB-5vj7A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		6 / 12 GLY A 163
GLY A 458
GLY A 460
GLY A 166
VAL A  58
ILE A 454
 FAD  A 503 (-3.4A)
None
None
None
None
SF4  A 501 ( 4.3A)
 1.49A 2pxcA-5vj7A:
3.1		 2pxcA-5vj7A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		4 / 8 GLY A 444
ILE A 233
VAL A 157
THR A 435
 FAD  A 503 (-3.4A)
None
None
None
 0.94A 2yoeB-5vj7A:
undetectable
2yoeC-5vj7A:
undetectable		 2yoeB-5vj7A:
22.33
2yoeC-5vj7A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 9 ALA A 242
ASP A 241
ILE A 182
ALA A 464
ILE A 467
 None
 1.04A 3ektB-5vj7A:
undetectable		 3ektB-5vj7A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 9 ILE A 122
GLY A  98
PRO A  57
VAL A  58
ILE A  60
 SF4  A 501 ( 4.7A)
SF4  A 501 ( 4.4A)
None
None
SF4  A 501 ( 4.6A)
 1.18A 3ekyB-5vj7A:
undetectable		 3ekyB-5vj7A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 10 GLY A 264
ILE A 357
GLY A 259
ILE A 260
PRO A 353
 None
 0.96A 3el9B-5vj7A:
undetectable		 3el9B-5vj7A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		6 / 10 ILE A 122
GLY A 123
GLY A  98
PRO A  57
VAL A  58
ILE A  60
 SF4  A 501 ( 4.7A)
SF4  A 501 ( 4.3A)
SF4  A 501 ( 4.4A)
None
None
SF4  A 501 ( 4.6A)
 1.13A 3em4V-5vj7A:
undetectable		 3em4V-5vj7A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		3 / 3 CYH A 169
PRO A 164
ASP A 459
 None
FAD  A 503 (-3.3A)
None
 1.01A 3hlwB-5vj7A:
undetectable		 3hlwB-5vj7A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5vj7 OXIDOREDUCTASE
FERREDOXIN-NADP(+)
REDUCTASE SUBUNIT
ALPHA
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 PRO B 221
GLY B 226
ILE A 226
THR A 230
LEU B  90
 FAD  B 301 (-4.8A)
FES  B 302 (-3.5A)
None
None
None
 1.23A 3iv6A-5vj7B:
4.9		 3iv6A-5vj7B:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 245
GLY A 246
ALA A 456
ALA A 162
ALA A 249
 None
None
FAD  A 503 (-2.7A)
FAD  A 503 (-4.8A)
None
 1.07A 3jb1A-5vj7A:
2.5		 3jb1A-5vj7A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 245
GLY A 246
ALA A 456
ALA A 162
ALA A 249
 None
None
FAD  A 503 (-2.7A)
FAD  A 503 (-4.8A)
None
 0.95A 3jb2A-5vj7A:
2.9		 3jb2A-5vj7A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 245
GLY A 246
ALA A 456
ALA A 162
ALA A 249
 None
None
FAD  A 503 (-2.7A)
FAD  A 503 (-4.8A)
None
 0.98A 3jb3A-5vj7A:
undetectable		 3jb3A-5vj7A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 11 ALA A 309
ALA A 312
VAL A 345
ALA A 301
GLY A 300
 None
 0.88A 3mg0K-5vj7A:
undetectable
3mg0L-5vj7A:
undetectable		 3mg0K-5vj7A:
17.44
3mg0L-5vj7A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 ALA A 309
ALA A 312
VAL A 345
ALA A 301
GLY A 300
 None
 0.88A 3mg0Y-5vj7A:
undetectable
3mg0Z-5vj7A:
undetectable		 3mg0Y-5vj7A:
17.44
3mg0Z-5vj7A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_1
(PROTEASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 264
ILE A 357
GLY A 259
ILE A 260
PRO A 353
 None
 0.91A 3nduA-5vj7A:
undetectable		 3nduA-5vj7A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 264
ILE A 357
GLY A 259
ILE A 260
PRO A 353
 None
 0.90A 3nduC-5vj7A:
undetectable		 3nduC-5vj7A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 9 ILE A 122
GLY A  98
PRO A  57
VAL A  58
ILE A  60
 SF4  A 501 ( 4.7A)
SF4  A 501 ( 4.4A)
None
None
SF4  A 501 ( 4.6A)
 1.09A 3nuoA-5vj7A:
undetectable		 3nuoA-5vj7A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 ALA A 249
GLY A 443
GLY A 246
ILE A 245
LEU A 433
 None
 1.00A 3o7wA-5vj7A:
undetectable		 3o7wA-5vj7A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 10 ILE A 122
GLY A  98
PRO A  57
VAL A  58
ILE A  60
 SF4  A 501 ( 4.7A)
SF4  A 501 ( 4.4A)
None
None
SF4  A 501 ( 4.6A)
 1.09A 3oxvB-5vj7A:
undetectable		 3oxvB-5vj7A:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 11 ILE A 233
VAL A 243
PHE A 244
VAL A 440
ILE A 159
 None
 1.09A 3rf4A-5vj7A:
undetectable
3rf4C-5vj7A:
undetectable		 3rf4A-5vj7A:
14.41
3rf4C-5vj7A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 11 ILE A 159
ILE A 233
VAL A 243
PHE A 244
VAL A 440
 None
 1.13A 3rf4A-5vj7A:
undetectable
3rf4B-5vj7A:
undetectable		 3rf4A-5vj7A:
14.41
3rf4B-5vj7A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 11 ILE A 159
ILE A 233
VAL A 243
PHE A 244
VAL A 440
 None
 1.06A 3rf4B-5vj7A:
undetectable
3rf4C-5vj7A:
undetectable		 3rf4B-5vj7A:
14.41
3rf4C-5vj7A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		4 / 5 LEU A  93
LEU A 167
GLY A 166
GLY A 163
 None
None
None
FAD  A 503 (-3.4A)
 0.79A 3si7C-5vj7A:
undetectable
3si7D-5vj7A:
undetectable		 3si7C-5vj7A:
21.22
3si7D-5vj7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_1
(PROTEASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 264
ILE A 357
GLY A 259
ILE A 260
PRO A 353
 None
 0.89A 3tkgA-5vj7A:
undetectable		 3tkgA-5vj7A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 264
ILE A 357
GLY A 259
ILE A 260
PRO A 353
 None
 0.95A 3tkgB-5vj7A:
undetectable		 3tkgB-5vj7A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 433
GLY A 246
ILE A 427
ILE A 159
ALA A 165
 None
None
None
None
FAD  A 503 (-3.8A)
 1.15A 3uj7A-5vj7A:
undetectable		 3uj7A-5vj7A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 246
GLY A 248
ILE A 447
PHE A 244
ALA A 162
 None
FAD  A 503 (-3.1A)
None
None
FAD  A 503 (-4.8A)
 0.92A 4a6dA-5vj7A:
undetectable		 4a6dA-5vj7A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 246
GLY A 248
ILE A 447
PHE A 244
ALA A 162
 None
FAD  A 503 (-3.1A)
None
None
FAD  A 503 (-4.8A)
 0.94A 4a6eA-5vj7A:
2.8		 4a6eA-5vj7A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		4 / 8 VAL A 243
CYH A 169
ILE A 245
ILE A 159
 None
 0.97A 4afgD-5vj7A:
undetectable
4afgE-5vj7A:
undetectable		 4afgD-5vj7A:
19.21
4afgE-5vj7A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 11 GLY A 444
GLY A 248
ILE A 245
ASP A 445
PRO A 164
 FAD  A 503 (-3.4A)
FAD  A 503 (-3.1A)
None
FAD  A 503 (-2.0A)
FAD  A 503 (-3.3A)
 1.15A 4dcmA-5vj7A:
3.3		 4dcmA-5vj7A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 166
ALA A 170
ALA A 464
ASP A 459
ALA A 456
 None
None
None
None
FAD  A 503 (-2.7A)
 1.28A 4df3A-5vj7A:
4.5		 4df3A-5vj7A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		4 / 7 TYR A 132
HIS A 136
ILE A 138
PRO A  76
 None
 0.75A 4g5jA-5vj7A:
undetectable		 4g5jA-5vj7A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 11 GLY A 264
ILE A 357
GLY A 259
ILE A 260
PRO A 353
 None
 0.98A 4njvC-5vj7A:
undetectable		 4njvC-5vj7A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 5vj7 FERREDOXIN-NADP(+)
REDUCTASE SUBUNIT
ALPHA
OXIDOREDUCTASE
(Pyrococcus
furiosus) 		3 / 3 GLN A 188
HIS A 187
ARG B  44
 None
 0.76A 4qyqA-5vj7A:
undetectable		 4qyqA-5vj7A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 5vj7 FERREDOXIN-NADP(+)
REDUCTASE SUBUNIT
ALPHA
OXIDOREDUCTASE
(Pyrococcus
furiosus) 		3 / 3 GLN A 188
HIS A 187
ARG B  44
 None
 0.78A 4qyqB-5vj7A:
undetectable		 4qyqB-5vj7A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 THR A 232
VAL A 227
GLN A 234
GLU A 418
ILE A 245
 None
FAD  A 503 (-4.1A)
None
None
None
 1.19A 4s0vA-5vj7A:
3.4		 4s0vA-5vj7A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		4 / 5 GLY A 109
ALA A 110
GLY A 114
PRO A 119
 None
 0.86A 4u9uA-5vj7A:
2.8		 4u9uA-5vj7A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		4 / 5 GLY A 109
ALA A 110
GLY A 114
PRO A 119
 None
 0.83A 4u9uB-5vj7A:
3.8		 4u9uB-5vj7A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 5vj7 FERREDOXIN-NADP(+)
REDUCTASE SUBUNIT
ALPHA
(Pyrococcus
furiosus) 		5 / 12 HIS B 220
GLU B 113
GLY B 110
GLY B  31
PRO B 249
 FAD  B 301 (-3.5A)
FAD  B 301 (-3.3A)
None
None
FAD  B 301 ( 4.0A)
 1.31A 4uinH-5vj7B:
undetectable
4uinL-5vj7B:
undetectable		 4uinH-5vj7B:
19.56
4uinL-5vj7B:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 5vj7 FERREDOXIN-NADP(+)
REDUCTASE SUBUNIT
ALPHA
(Pyrococcus
furiosus) 		5 / 11 PHE B 193
GLY B 248
VAL B 195
GLU B 113
THR B  48
 None
None
None
FAD  B 301 (-3.3A)
FAD  B 301 (-3.4A)
 1.13A 4zmeA-5vj7B:
undetectable		 4zmeA-5vj7B:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		4 / 8 ILE A  96
LEU A 193
ILE A 206
LEU A 207
 None
 0.77A 4zvcA-5vj7A:
undetectable
4zvcB-5vj7A:
undetectable		 4zvcA-5vj7A:
14.38
4zvcB-5vj7A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		4 / 8 ILE A 206
LEU A 207
ILE A  96
LEU A 193
 None
 0.77A 4zvcA-5vj7A:
undetectable
4zvcB-5vj7A:
undetectable		 4zvcA-5vj7A:
14.38
4zvcB-5vj7A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 11 GLU A 104
GLN A 106
GLU A 108
GLY A  98
GLY A 123
 None
SF4  A 501 (-4.4A)
None
SF4  A 501 ( 4.4A)
SF4  A 501 ( 4.3A)
 1.21A 5e3iB-5vj7A:
3.4		 5e3iB-5vj7A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		6 / 12 GLY A 163
GLY A 458
GLY A 460
GLY A 166
VAL A  58
ILE A 454
 FAD  A 503 (-3.4A)
None
None
None
None
SF4  A 501 ( 4.3A)
 1.49A 5ec8A-5vj7A:
3.2		 5ec8A-5vj7A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 246
GLY A 458
GLY A 460
GLY A 166
VAL A  58
 None
 0.99A 5ekxA-5vj7A:
3.2		 5ekxA-5vj7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 5vj7 OXIDOREDUCTASE
FERREDOXIN-NADP(+)
REDUCTASE SUBUNIT
ALPHA
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		3 / 3 THR A 251
ASP B 225
GLU A 270
 None
FES  B 302 (-2.5A)
None
 0.85A 5fa8A-5vj7A:
undetectable		 5fa8A-5vj7A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 246
GLY A 458
GLY A 460
GLY A 166
VAL A  58
 None
 0.95A 5kqrA-5vj7A:
undetectable		 5kqrA-5vj7A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 9 ILE A 122
GLY A  98
PRO A  57
VAL A  58
ILE A  60
 SF4  A 501 ( 4.7A)
SF4  A 501 ( 4.4A)
None
None
SF4  A 501 ( 4.6A)
 1.09A 5kr0A-5vj7A:
undetectable		 5kr0A-5vj7A:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 9 ALA A 308
ASP A 307
GLY A 300
ILE A 299
PRO A 252
 None
FAD  A 503 ( 3.6A)
None
None
None
 1.28A 5kr2A-5vj7A:
undetectable		 5kr2A-5vj7A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 11 ILE A 233
ILE A 160
THR A 435
ILE A 427
ALA A 446
 None
 1.13A 5lg3A-5vj7A:
undetectable		 5lg3A-5vj7A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		6 / 12 GLY A 163
GLY A 458
GLY A 460
GLY A 166
VAL A  58
ILE A 454
 FAD  A 503 (-3.4A)
None
None
None
None
SF4  A 501 ( 4.3A)
 1.50A 5m5bA-5vj7A:
2.9		 5m5bA-5vj7A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 246
GLY A 458
GLY A 460
GLY A 166
VAL A  58
 None
 0.95A 5m5bA-5vj7A:
2.9		 5m5bA-5vj7A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		3 / 3 SER A 267
ALA A 268
THR A 304
 None
None
FAD  A 503 (-2.0A)
 0.73A 5n0xB-5vj7A:
undetectable		 5n0xB-5vj7A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 9 CYH A 101
GLN A 103
GLY A 123
GLY A  98
ALA A  95
 SF4  A 501 (-2.2A)
SF4  A 501 (-4.5A)
SF4  A 501 ( 4.3A)
SF4  A 501 ( 4.4A)
None
 1.26A 5v3cA-5vj7A:
undetectable		 5v3cA-5vj7A:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		6 / 12 GLY A 163
GLY A 458
GLY A 460
GLY A 166
VAL A  58
ILE A 454
 FAD  A 503 (-3.4A)
None
None
None
None
SF4  A 501 ( 4.3A)
 1.45A 5vimA-5vj7A:
2.9		 5vimA-5vj7A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		6 / 12 GLY A 161
GLY A 166
ILE A 245
VAL A 227
ILE A 221
LEU A 236
 FAD  A 503 (-3.1A)
None
None
FAD  A 503 (-4.1A)
None
None
 1.27A 5wy0A-5vj7A:
undetectable		 5wy0A-5vj7A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 163
GLY A 458
GLY A 166
VAL A  58
ILE A 454
 FAD  A 503 (-3.4A)
None
None
None
SF4  A 501 ( 4.3A)
 1.01A 5wz1A-5vj7A:
undetectable		 5wz1A-5vj7A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 163
GLY A 458
GLY A 166
VAL A  58
ILE A 454
 FAD  A 503 (-3.4A)
None
None
None
SF4  A 501 ( 4.3A)
 1.02A 5wz1C-5vj7A:
2.8		 5wz1C-5vj7A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 163
GLY A 458
GLY A 166
VAL A  58
ILE A 454
 FAD  A 503 (-3.4A)
None
None
None
SF4  A 501 ( 4.3A)
 1.03A 5wz1D-5vj7A:
3.1		 5wz1D-5vj7A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 163
GLY A 458
GLY A 166
VAL A  58
ILE A 454
 FAD  A 503 (-3.4A)
None
None
None
SF4  A 501 ( 4.3A)
 1.02A 5wz1E-5vj7A:
3.0		 5wz1E-5vj7A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 163
GLY A 458
GLY A 166
VAL A  58
ILE A 454
 FAD  A 503 (-3.4A)
None
None
None
SF4  A 501 ( 4.3A)
 1.01A 5wz1F-5vj7A:
3.1		 5wz1F-5vj7A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 163
GLY A 458
GLY A 166
VAL A  58
ILE A 454
 FAD  A 503 (-3.4A)
None
None
None
SF4  A 501 ( 4.3A)
 1.02A 5wz1H-5vj7A:
undetectable		 5wz1H-5vj7A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 5vj7 FERREDOXIN-NADP(+)
REDUCTASE SUBUNIT
ALPHA
(Pyrococcus
furiosus) 		4 / 6 GLN B 122
HIS B 152
VAL B 128
LEU B 103
 None
 1.15A 5xdhA-5vj7B:
undetectable
5xdhC-5vj7B:
undetectable		 5xdhA-5vj7B:
17.87
5xdhC-5vj7B:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5vj7 OXIDOREDUCTASE
(Pyrococcus
furiosus) 		3 / 3 ASN A 303
VAL A  26
HIS A 339
 FAD  A 503 (-3.2A)
None
None
 0.75A 6a5yD-5vj7A:
undetectable		 6a5yD-5vj7A:
11.44