SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vjt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)
5vjt REACTION CENTER
MAQUETTE

(synthetic
construct)
5 / 12 LEU A 142
GLU A 153
LEU A  41
GLY A 164
LEU A 162
None
1.21A 1g50B-5vjtA:
undetectable
1g50B-5vjtA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)
5vjt REACTION CENTER
MAQUETTE

(synthetic
construct)
5 / 11 LEU A 142
GLU A 153
LEU A  41
GLY A 164
LEU A 162
None
1.20A 1g50C-5vjtA:
undetectable
1g50C-5vjtA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)
5vjt REACTION CENTER
MAQUETTE

(synthetic
construct)
5 / 11 GLU A  64
HIS A  67
GLU A 161
ILE A 131
GLU A 135
ZN  A 202 (-2.3A)
ZN  A 202 (-3.0A)
None
None
ZN  A 202 (-2.3A)
0.90A 1rnrA-5vjtA:
3.2
1rnrA-5vjtA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)
5vjt REACTION CENTER
MAQUETTE

(synthetic
construct)
5 / 11 GLU A  64
HIS A 138
LEU A  71
GLU A  34
GLU A 135
ZN  A 202 (-2.3A)
ZN  A 201 ( 3.0A)
None
ZN  A 202 (-2.1A)
ZN  A 202 (-2.3A)
1.50A 1rnrA-5vjtA:
3.2
1rnrA-5vjtA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)
5vjt REACTION CENTER
MAQUETTE

(synthetic
construct)
5 / 11 GLU A 135
HIS A 138
GLU A  34
ILE A  60
GLU A  64
ZN  A 202 (-2.3A)
ZN  A 201 ( 3.0A)
ZN  A 202 (-2.1A)
None
ZN  A 202 (-2.3A)
0.96A 1rnrA-5vjtA:
3.2
1rnrA-5vjtA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)
5vjt REACTION CENTER
MAQUETTE

(synthetic
construct)
5 / 12 GLU A  64
HIS A  67
GLU A 161
ILE A 131
GLU A 135
ZN  A 202 (-2.3A)
ZN  A 202 (-3.0A)
None
None
ZN  A 202 (-2.3A)
0.93A 1rnrB-5vjtA:
5.1
1rnrB-5vjtA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)
5vjt REACTION CENTER
MAQUETTE

(synthetic
construct)
5 / 12 GLU A 135
HIS A 138
GLU A  34
ILE A  60
GLU A  64
ZN  A 202 (-2.3A)
ZN  A 201 ( 3.0A)
ZN  A 202 (-2.1A)
None
ZN  A 202 (-2.3A)
1.00A 1rnrB-5vjtA:
5.1
1rnrB-5vjtA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)
5vjt REACTION CENTER
MAQUETTE

(synthetic
construct)
5 / 12 LEU A  85
LEU A 120
LEU A 121
HIS A 110
LEU A 113
HEM  A 203 ( 4.8A)
None
None
HEM  A 203 (-3.1A)
None
1.08A 3erdA-5vjtA:
undetectable
3erdA-5vjtA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)
5vjt REACTION CENTER
MAQUETTE

(synthetic
construct)
4 / 6 GLN A  97
LEU A  95
GLU A  94
LEU A 106
None
HEM  A 203 ( 4.5A)
None
None
0.91A 3h5gA-5vjtA:
undetectable
3h5gC-5vjtA:
undetectable
3h5gA-5vjtA:
undetectable
3h5gC-5vjtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)
5vjt REACTION CENTER
MAQUETTE

(synthetic
construct)
5 / 10 GLY A  27
GLU A  29
LEU A  71
LEU A  74
ILE A 131
None
1.28A 3kvrB-5vjtA:
undetectable
3kvrB-5vjtA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)
5vjt REACTION CENTER
MAQUETTE

(synthetic
construct)
5 / 12 GLU A  64
LEU A  30
LEU A 162
GLY A 160
ILE A 165
ZN  A 202 (-2.3A)
None
None
None
None
1.08A 5j7wD-5vjtA:
undetectable
5j7wD-5vjtA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)
5vjt REACTION CENTER
MAQUETTE

(synthetic
construct)
5 / 12 GLU A 135
LEU A 157
LEU A  35
GLY A  33
ILE A  38
ZN  A 202 (-2.3A)
None
None
None
None
1.07A 5j7wD-5vjtA:
undetectable
5j7wD-5vjtA:
15.65