SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vjy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5vjy DUTP PYROPHOSPHATASE
(Naegleria
fowleri) 		3 / 3 ARG A 109
ARG A  66
ILE A 104
 None
 0.76A 1uobA-5vjyA:
undetectable		 1uobA-5vjyA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5vjy DUTP PYROPHOSPHATASE
(Naegleria
fowleri) 		5 / 9 PHE A 113
VAL A  82
MET A   7
SER A   2
LEU A  90
 None
BTB  A 201 ( 4.3A)
None
None
None
 1.40A 1wrkA-5vjyA:
undetectable
1wrkB-5vjyA:
undetectable		 1wrkA-5vjyA:
16.77
1wrkB-5vjyA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 5vjy DUTP PYROPHOSPHATASE
(Naegleria
fowleri) 		4 / 6 PRO A   4
HIS A  57
ASP A  83
TYR A  59
 None
 1.33A 2lh8A-5vjyA:
undetectable		 2lh8A-5vjyA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5vjy DUTP PYROPHOSPHATASE
(Naegleria
fowleri) 		4 / 7 LEU A  31
THR A  49
PRO A  19
LEU A  12
 None
 0.96A 5fxtA-5vjyA:
undetectable		 5fxtA-5vjyA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 5vjy DUTP PYROPHOSPHATASE
(Naegleria
fowleri) 		4 / 5 TYR A  37
ILE A 104
LEU A  90
GLY A  91
 None
None
None
BTB  A 201 (-3.5A)
 0.87A 5kmdC-5vjyA:
undetectable
5kmdD-5vjyA:
undetectable		 5kmdC-5vjyA:
18.82
5kmdD-5vjyA:
18.82