SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vk2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 5vk2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Lassa
mammarenavirus) 		4 / 8 THR a 274
PRO a 275
GLY a 276
THR a 296
 None
 0.79A 1h4oB-5vk2a:
undetectable		 1h4oB-5vk2a:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 5vk2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Lassa
mammarenavirus) 		4 / 8 THR a 274
PRO a 275
GLY a 276
THR a 296
 None
 0.78A 1oc3A-5vk2a:
undetectable		 1oc3A-5vk2a:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 5vk2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Lassa
mammarenavirus) 		3 / 3 ARG A 193
ILE A 239
TRP A 196
 None
 1.10A 1qomA-5vk2A:
undetectable		 1qomA-5vk2A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 5vk2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Lassa
mammarenavirus) 		4 / 5 ILE a 337
SER A 246
ARG A 248
ASN a 338
 None
 0.88A 1y0xX-5vk2a:
undetectable		 1y0xX-5vk2a:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 5vk2 FAB 37.7H HEAVY
CHAIN
PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Homo
sapiens;
Lassa
mammarenavirus) 		4 / 5 SER D 107
ASP a 268
PRO a 275
SER D 104
 None
 1.47A 2hdnA-5vk2D:
undetectable
2hdnB-5vk2D:
undetectable
2hdnD-5vk2D:
undetectable		 2hdnA-5vk2D:
12.44
2hdnB-5vk2D:
20.58
2hdnD-5vk2D:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 5vk2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Lassa
mammarenavirus) 		4 / 7 THR a 274
PRO a 275
GLY a 276
THR a 296
 None
 0.83A 2vl2B-5vk2a:
undetectable		 2vl2B-5vk2a:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5vk2 FAB 37.7H HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 ARG D 103
ILE D  38
TRP D  48
 None
 1.00A 3e68A-5vk2D:
undetectable		 3e68A-5vk2D:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 5vk2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Lassa
mammarenavirus) 		3 / 3 ASN a 302
ASP a 317
GLN a 321
 None
 0.67A 3eeyC-5vk2a:
undetectable		 3eeyC-5vk2a:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 5vk2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Lassa
mammarenavirus) 		3 / 3 ASN a 302
ASP a 317
GLN a 321
 None
 0.66A 3eeyD-5vk2a:
undetectable		 3eeyD-5vk2a:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 5vk2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Lassa
mammarenavirus) 		3 / 3 ASN a 302
ASP a 317
GLN a 321
 None
 0.66A 3eeyE-5vk2a:
undetectable		 3eeyE-5vk2a:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5vk2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Lassa
mammarenavirus) 		5 / 10 ILE A 136
ILE A  95
TYR A 166
VAL A 164
LEU A 244
 None
 1.39A 3elzB-5vk2A:
undetectable		 3elzB-5vk2A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 5vk2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Lassa
mammarenavirus) 		4 / 7 PHE a 293
VAL a 298
ASN a 295
GLY a 277
 NAG  a 505 ( 4.1A)
None
None
None
 1.00A 3kmoB-5vk2a:
undetectable		 3kmoB-5vk2a:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5vk2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Lassa
mammarenavirus) 		4 / 8 GLU a 308
ASN a 346
ASN a 353
ILE A 239
 None
 1.18A 3kp6A-5vk2a:
undetectable
3kp6B-5vk2a:
undetectable		 3kp6A-5vk2a:
19.77
3kp6B-5vk2a:
19.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5vk2 FAB 37.7H HEAVY
CHAIN
(Homo
sapiens) 		5 / 11 VAL D   3
ALA D  25
MET D  35
ARG D  74
ASN D  76
 None
 0.79A 3qxvC-5vk2D:
20.5		 3qxvC-5vk2D:
40.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GCP_A_AICA401_1
(OUTER MEMBRANE
PROTEIN F)		 5vk2 FAB 37.7H HEAVY
CHAIN
PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Homo
sapiens;
Lassa
mammarenavirus) 		5 / 9 GLY a 294
ASP a 273
TYR D  33
SER D  31
ARG D  55
 None
 1.07A 4gcpA-5vk2a:
0.0		 4gcpA-5vk2a:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GCP_B_AICB401_1
(OUTER MEMBRANE
PROTEIN F)		 5vk2 FAB 37.7H HEAVY
CHAIN
PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Homo
sapiens;
Lassa
mammarenavirus) 		5 / 9 GLY a 294
ASP a 273
TYR D  33
SER D  31
ARG D  55
 None
 1.07A 4gcpB-5vk2a:
undetectable		 4gcpB-5vk2a:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5vk2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Lassa
mammarenavirus;
Lassa
mammarenavirus) 		4 / 8 ARG A 248
ASN a 342
ASP a 347
ILE a 345
 None
 0.99A 4l7iA-5vk2A:
undetectable		 4l7iA-5vk2A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5vk2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Lassa
mammarenavirus) 		3 / 3 MET A 192
GLN A 189
ARG A 193
 None
 1.14A 6fn9A-5vk2A:
undetectable		 6fn9A-5vk2A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5vk2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Lassa
mammarenavirus) 		3 / 3 MET A 192
GLN A 189
ARG A 193
 None
 1.14A 6fnbA-5vk2A:
undetectable		 6fnbA-5vk2A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 5vk2 FAB 37.7H HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 VAL D 174
VAL D 193
SER D 191
ASN D 208
ASN D 166
 None
 1.46A 6h7mB-5vk2D:
undetectable		 6h7mB-5vk2D:
18.06