SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vk4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Neisseria
gonorrhoeae) 		5 / 9 GLY A  82
GLY A  66
LEU A  69
SER A 189
GLY A  64
 None
 1.07A 1jhrA-5vk4A:
undetectable		 1jhrA-5vk4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Neisseria
gonorrhoeae) 		5 / 9 GLY A  82
GLY A  66
LEU A  69
SER A 189
GLY A  64
 None
 1.07A 1jhyA-5vk4A:
undetectable		 1jhyA-5vk4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Neisseria
gonorrhoeae) 		5 / 9 GLY A  82
GLY A  66
LEU A  69
SER A 189
GLY A  64
 None
 1.06A 1l4nA-5vk4A:
undetectable		 1l4nA-5vk4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Neisseria
gonorrhoeae) 		5 / 9 GLY A  82
GLY A  66
LEU A  69
SER A 189
GLY A  64
 None
 1.05A 1l5kA-5vk4A:
undetectable		 1l5kA-5vk4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Neisseria
gonorrhoeae) 		5 / 9 GLY A  82
GLY A  66
LEU A  69
SER A 189
GLY A  64
 None
 1.06A 1l5lA-5vk4A:
undetectable		 1l5lA-5vk4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Neisseria
gonorrhoeae) 		5 / 9 GLY A  82
GLY A  66
LEU A  69
SER A 189
GLY A  64
 None
 1.06A 1l5mA-5vk4A:
undetectable		 1l5mA-5vk4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Neisseria
gonorrhoeae) 		4 / 8 SER A 131
THR A  80
ASP A  79
LEU A 226
 None
 1.02A 1lhvA-5vk4A:
undetectable		 1lhvA-5vk4A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Neisseria
gonorrhoeae) 		3 / 3 VAL A  86
ALA A  87
HIS A 188
 None
 0.51A 1q23G-5vk4A:
undetectable		 1q23G-5vk4A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Neisseria
gonorrhoeae) 		3 / 3 VAL A  86
ALA A  87
HIS A 188
 None
 0.61A 1q23L-5vk4A:
undetectable		 1q23L-5vk4A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Neisseria
gonorrhoeae) 		3 / 3 VAL A  86
ALA A  87
HIS A 188
 None
 0.46A 1q23J-5vk4A:
undetectable		 1q23J-5vk4A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Neisseria
gonorrhoeae) 		4 / 5 LEU A  58
ARG A  33
ILE A 136
PHE A 102
 None
 1.27A 3ln1D-5vk4A:
undetectable		 3ln1D-5vk4A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Neisseria
gonorrhoeae) 		4 / 4 GLY A  17
GLU A 142
ASP A 113
ASP A  18
 None
 1.19A 3mb5A-5vk4A:
undetectable		 3mb5A-5vk4A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Neisseria
gonorrhoeae) 		4 / 4 SER A 184
ASP A  84
ASP A  79
ALA A 222
 None
 1.39A 3uj6A-5vk4A:
undetectable		 3uj6A-5vk4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Neisseria
gonorrhoeae) 		3 / 3 TYR A 192
ASP A  84
ASP A  63
 None
None
MG  A 402 ( 3.6A)
 0.82A 4a6eA-5vk4A:
undetectable		 4a6eA-5vk4A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Neisseria
gonorrhoeae) 		4 / 8 ILE A 121
ILE A 124
PHE A 103
GLY A 156
 ANP  A 401 (-4.5A)
None
None
None
 0.83A 4acbC-5vk4A:
undetectable		 4acbC-5vk4A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Neisseria
gonorrhoeae) 		6 / 12 GLY A  82
GLY A 127
GLU A 130
ASP A 119
VAL A 120
ASP A  84
 None
 1.48A 4ctkA-5vk4A:
undetectable		 4ctkA-5vk4A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIS_A_DAHA24_1
(POLYSACCHARIDE
MONOOXYGENASE-3)		 5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Neisseria
gonorrhoeae) 		4 / 5 TYR A 227
PRO A 230
ASN A  91
PRO A 100
 None
 1.41A 4eisA-5vk4A:
0.0
4eisB-5vk4A:
0.0		 4eisA-5vk4A:
17.82
4eisB-5vk4A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Neisseria
gonorrhoeae) 		4 / 8 HIS A 188
ARG A 225
ASN A 297
ILE A 251
 None
 0.98A 4k0bA-5vk4A:
undetectable		 4k0bA-5vk4A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Neisseria
gonorrhoeae) 		5 / 9 GLY A  82
GLY A  66
LEU A  69
SER A 189
GLY A  64
 None
 1.07A 4kqiA-5vk4A:
undetectable		 4kqiA-5vk4A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Neisseria
gonorrhoeae) 		4 / 8 VAL A 255
TYR A 293
TRP A 272
LEU A 328
 None
 1.19A 4q0bA-5vk4A:
undetectable		 4q0bA-5vk4A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Neisseria
gonorrhoeae) 		6 / 12 GLY A  82
GLY A 127
GLU A 130
ASP A 119
VAL A 120
ASP A  84
 None
 1.46A 5e9qA-5vk4A:
undetectable		 5e9qA-5vk4A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Neisseria
gonorrhoeae) 		6 / 12 GLY A  82
GLY A 127
LYS A 122
GLU A 130
ASP A 119
ASP A  84
 None
 1.37A 5e9qA-5vk4A:
undetectable		 5e9qA-5vk4A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)		 5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Neisseria
gonorrhoeae) 		6 / 12 GLY A  82
GLY A 127
GLU A 130
ASP A 119
VAL A 120
ASP A  84
 None
 1.49A 5e9qC-5vk4A:
undetectable		 5e9qC-5vk4A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Neisseria
gonorrhoeae) 		6 / 12 GLY A  82
GLY A 127
GLU A 130
ASP A 119
VAL A 120
ASP A  84
 None
 1.48A 5eifA-5vk4A:
undetectable		 5eifA-5vk4A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Neisseria
gonorrhoeae) 		4 / 7 ALA A 125
GLY A 123
GLY A  82
THR A  31
 None
 0.72A 5ybbB-5vk4A:
undetectable		 5ybbB-5vk4A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Neisseria
gonorrhoeae) 		4 / 7 GLU A 130
ARG A 225
THR A 224
PRO A 223
 None
 1.40A 6a4iB-5vk4A:
undetectable		 6a4iB-5vk4A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Neisseria
gonorrhoeae) 		5 / 12 ILE A 198
LEU A  85
VAL A  81
VAL A 220
PHE A  73
 None
 1.48A 6a7pB-5vk4A:
undetectable		 6a7pB-5vk4A:
20.95