SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vkp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2LH6_A_NIOA155_1 (LEGHEMOGLOBIN A (NICOTINATE MET))	5vkp	POTASSIUM CHANNEL SUBFAMILY K MEMBER 2 (Mus musculus)	4 / 5	PHE A 230 PHE A 244 PHE A 145 VAL A 274	None None None Q5F A 404 (-3.7A)	1.25A	2lh6A-5vkpA: 1.0	2lh6A-5vkpA: 21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PKK_A_2FAA501_2 (ADENOSINE KINASE)	5vkp	POTASSIUM CHANNEL SUBFAMILY K MEMBER 2 (Mus musculus)	4 / 4	ALA A 241 VAL A 223 PHE A 230 THR A 248	None	1.46A	2pkkA-5vkpA: undetectable	2pkkA-5vkpA: 22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OWX_B_XRAB233_1 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	5vkp	POTASSIUM CHANNEL SUBFAMILY K MEMBER 2 (Mus musculus)	5 / 11	VAL A 273 PHE A 145 GLY A 260 GLY A 261 ASN A 147	None None Q5F A 404 (-4.2A) Q5F A 404 ( 3.7A) None	1.48A	3owxA-5vkpA: undetectable 3owxB-5vkpA: undetectable	3owxA-5vkpA: 20.70 3owxB-5vkpA: 20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V4T_H_ACTH503_0 (UDP-N-ACETYLGLUCOSAM INE 1-CARBOXYVINYLTRANSF ERASE)	5vkp	POTASSIUM CHANNEL SUBFAMILY K MEMBER 2 (Mus musculus)	4 / 7	ILE A 148 ARG A 151 HIS A 126 GLY A 113	None	0.84A	3v4tH-5vkpA: undetectable	3v4tH-5vkpA: 21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_C_PCFC1801_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	5vkp	POTASSIUM CHANNEL SUBFAMILY K MEMBER 2 (Mus musculus)	4 / 9	LYS A 156 ILE A 157 ILE A 161 LEU A 164	None None R16 A 407 ( 4.5A) R16 A 407 (-4.8A)	0.74A	5vkqB-5vkpA: 5.2 5vkqC-5vkpA: 5.2	5vkqB-5vkpA: 10.58 5vkqC-5vkpA: 10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HCO_A_FY5A1003_0 (ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2)	5vkp	POTASSIUM CHANNEL SUBFAMILY K MEMBER 2 (Mus musculus)	5 / 11	PHE A 134 VAL A 258 THR A 141 ILE A 140 VAL A 139	Q5F A 404 (-3.7A) None Q5F A 404 ( 3.9A) None None	1.36A	6hcoA-5vkpA: undetectable 6hcoB-5vkpA: undetectable	6hcoA-5vkpA: 18.95 6hcoB-5vkpA: 18.95

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2LH6_A_NIOA155_1","LEGHEMOGLOBIN A (NICOTINATE MET)","5vkp","POTASSIUM CHANNEL SUBFAMILY K MEMBER 2","Mus musculus",4,"PHE A 230;PHE A 244;PHE A 145;VAL A 274","None;None;None;Q5F A 404 (-3.7A)","1.25A","2lh6A-5vkpA:1.0","2lh6A-5vkpA:21.07"],["2PKK_A_2FAA501_2","ADENOSINE KINASE","5vkp","POTASSIUM CHANNEL SUBFAMILY K MEMBER 2","Mus musculus",4,"ALA A 241;VAL A 223;PHE A 230;THR A 248","None","1.46A","2pkkA-5vkpA:undetectable","2pkkA-5vkpA:22.25"],["3OWX_B_XRAB233_1","RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE];RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE]","5vkp","POTASSIUM CHANNEL SUBFAMILY K MEMBER 2","Mus musculus",5,"VAL A 273;PHE A 145;GLY A 260;GLY A 261;ASN A 147","None;None;Q5F A 404 (-4.2A);Q5F A 404 ( 3.7A);None","1.48A","3owxA-5vkpA:undetectable;3owxB-5vkpA:undetectable","3owxA-5vkpA:20.70;3owxB-5vkpA:20.70"],["3V4T_H_ACTH503_0","UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE","5vkp","POTASSIUM CHANNEL SUBFAMILY K MEMBER 2","Mus musculus",4,"ILE A 148;ARG A 151;HIS A 126;GLY A 113","None","0.84A","3v4tH-5vkpA:undetectable","3v4tH-5vkpA:21.81"],["5VKQ_C_PCFC1801_0","NO MECHANORECEPTOR POTENTIAL C ISOFORM L","5vkp","POTASSIUM CHANNEL SUBFAMILY K MEMBER 2","Mus musculus",4,"LYS A 156;ILE A 157;ILE A 161;LEU A 164","None;None;R16 A 407 ( 4.5A);R16 A 407 (-4.8A)","0.74A","5vkqB-5vkpA:5.2;5vkqC-5vkpA:5.2","5vkqB-5vkpA:10.58;5vkqC-5vkpA:10.58"],["6HCO_A_FY5A1003_0","ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2","5vkp","POTASSIUM CHANNEL SUBFAMILY K MEMBER 2","Mus musculus",5,"PHE A 134;VAL A 258;THR A 141;ILE A 140;VAL A 139","Q5F A 404 (-3.7A);None;Q5F A 404 ( 3.9A);None;None","1.36A","6hcoA-5vkpA:undetectable;6hcoB-5vkpA:undetectable","6hcoA-5vkpA:18.95;6hcoB-5vkpA:18.95"]]