SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vkt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 5vkt CINNAMYL ALCOHOL
DEHYDROGENASES
(SBCAD4)
(Sorghum
bicolor) 		4 / 8 VAL A 151
VAL A  72
LEU A 155
PRO A 156
 None
 0.93A 2ddwA-5vktA:
3.4		 2ddwA-5vktA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 5vkt CINNAMYL ALCOHOL
DEHYDROGENASES
(SBCAD4)
(Sorghum
bicolor) 		5 / 12 TYR A  95
LEU A 194
CYH A  47
HIS A 258
LEU A 263
 FMT  A 404 (-3.4A)
NAP  A 405 (-3.6A)
ZN  A 401 (-2.3A)
None
None
 1.31A 2hc4A-5vktA:
undetectable		 2hc4A-5vktA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 5vkt CINNAMYL ALCOHOL
DEHYDROGENASES
(SBCAD4)
(Sorghum
bicolor) 		4 / 7 LEU A 141
PRO A  64
VAL A  66
MET A  62
 None
 1.26A 2hrcA-5vktA:
undetectable		 2hrcA-5vktA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 5vkt CINNAMYL ALCOHOL
DEHYDROGENASES
(SBCAD4)
(Sorghum
bicolor) 		5 / 12 SER A 215
GLY A 195
GLY A 190
VAL A 170
THR A 169
 NAP  A 405 (-2.7A)
None
NAP  A 405 (-3.3A)
None
NAP  A 405 (-2.7A)
 0.97A 2wa2B-5vktA:
4.6		 2wa2B-5vktA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5vkt CINNAMYL ALCOHOL
DEHYDROGENASES
(SBCAD4)
(Sorghum
bicolor) 		5 / 12 PHE A 137
PRO A  67
ALA A  14
ALA A 161
LEU A 339
 None
None
None
None
NAP  A 405 (-4.8A)
 1.23A 2x2nB-5vktA:
undetectable		 2x2nB-5vktA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 5vkt CINNAMYL ALCOHOL
DEHYDROGENASES
(SBCAD4)
(Sorghum
bicolor) 		4 / 8 PHE A 201
PHE A 205
ALA A 175
ALA A 310
 None
 0.79A 3t3sE-5vktA:
undetectable		 3t3sE-5vktA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5vkt CINNAMYL ALCOHOL
DEHYDROGENASES
(SBCAD4)
(Sorghum
bicolor) 		5 / 11 ASP A 125
ALA A 131
GLY A 130
VAL A 118
LYS A 134
 None
 1.31A 4c5lA-5vktA:
5.0		 4c5lA-5vktA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5vkt CINNAMYL ALCOHOL
DEHYDROGENASES
(SBCAD4)
(Sorghum
bicolor) 		5 / 12 GLY A  92
GLY A  73
LEU A 141
LEU A 164
CYH A 308
 None
None
None
None
GOL  A 403 (-3.0A)
 1.28A 4x61A-5vktA:
7.2		 4x61A-5vktA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5vkt CINNAMYL ALCOHOL
DEHYDROGENASES
(SBCAD4)
(Sorghum
bicolor) 		5 / 12 GLU A 221
ASP A 323
LEU A 191
GLY A 192
HIS A 196
 None
None
NAP  A 405 (-4.7A)
NAP  A 405 (-3.3A)
None
 1.49A 5axdA-5vktA:
3.7		 5axdA-5vktA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 5vkt CINNAMYL ALCOHOL
DEHYDROGENASES
(SBCAD4)
(Sorghum
bicolor) 		4 / 5 TYR A  63
PHE A 137
LEU A  51
PRO A  67
 None
 1.49A 5csyB-5vktA:
undetectable		 5csyB-5vktA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5vkt CINNAMYL ALCOHOL
DEHYDROGENASES
(SBCAD4)
(Sorghum
bicolor) 		5 / 12 ILE A 251
PHE A 201
VAL A 276
ASN A 112
ASP A 307
 None
None
NAP  A 405 (-3.4A)
None
None
 1.22A 5lg3J-5vktA:
undetectable		 5lg3J-5vktA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O45_B_CCSB13_0
(PHE-MEA-9KK-SAR-ASP-
VAL-MEA-TYR-SAR-TRP-
TYR-LEU-CCS-GLY-NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 5vkt CINNAMYL ALCOHOL
DEHYDROGENASES
(SBCAD4)
(Sorghum
bicolor) 		5 / 9 TYR A 346
GLU A 221
ASP A 220
VAL A 211
GLY A 217
 None
 1.21A 5o45A-5vktA:
0.0
5o45B-5vktA:
undetectable		 5o45A-5vktA:
19.14
5o45B-5vktA:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 5vkt CINNAMYL ALCOHOL
DEHYDROGENASES
(SBCAD4)
(Sorghum
bicolor) 		3 / 3 ASP A 252
SER A 214
SER A 234
 None
NAP  A 405 (-2.6A)
NAP  A 405 ( 4.7A)
 0.65A 6mxtA-5vktA:
undetectable		 6mxtA-5vktA:
20.55