SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vkw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5vkw ADENYLOSUCCINATE
LYASE
(Candida
albicans) 		4 / 7 VAL A 458
LEU A 359
ALA A 169
LEU A 173
 None
 0.86A 1pthA-5vkwA:
undetectable		 1pthA-5vkwA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5vkw ADENYLOSUCCINATE
LYASE
(Candida
albicans) 		4 / 7 VAL A 458
LEU A 359
ALA A 169
LEU A 173
 None
 0.86A 1pthB-5vkwA:
undetectable		 1pthB-5vkwA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5vkw ADENYLOSUCCINATE
LYASE
(Candida
albicans) 		5 / 9 ALA A 143
LEU A 139
VAL A 165
ILE A 266
LEU A 269
 None
 1.41A 3fl9D-5vkwA:
undetectable		 3fl9D-5vkwA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 5vkw ADENYLOSUCCINATE
LYASE
(Candida
albicans) 		5 / 12 LEU A 118
TYR A 233
ILE A 190
ALA A 186
ASP A 247
 None
 1.25A 3vw1D-5vkwA:
undetectable		 3vw1D-5vkwA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 5vkw ADENYLOSUCCINATE
LYASE
(Candida
albicans) 		4 / 5 LEU A 173
TRP A 172
ILE A 266
ASN A 354
 None
 1.33A 4i00A-5vkwA:
undetectable		 4i00A-5vkwA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5vkw ADENYLOSUCCINATE
LYASE
(Candida
albicans) 		4 / 4 ASN A 418
SER A 404
ALA A 407
VAL A 410
 None
 1.25A 4x1kC-5vkwA:
undetectable		 4x1kC-5vkwA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5vkw ADENYLOSUCCINATE
LYASE
(Candida
albicans) 		5 / 12 ASP A 137
VAL A 462
LEU A 173
THR A 170
ALA A 169
 None
 1.16A 4yhaA-5vkwA:
undetectable		 4yhaA-5vkwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 5vkw ADENYLOSUCCINATE
LYASE
(Candida
albicans) 		4 / 4 VAL A 232
LEU A 192
LEU A 118
ASP A 114
 None
 1.38A 5xv7A-5vkwA:
undetectable		 5xv7A-5vkwA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5vkw ADENYLOSUCCINATE
LYASE
(Candida
albicans) 		4 / 4 ASP A 179
ILE A 129
PRO A 130
LEU A 132
 None
 1.30A 6mkeB-5vkwA:
undetectable		 6mkeB-5vkwA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5vkw ADENYLOSUCCINATE
LYASE
(Candida
albicans) 		4 / 4 ASP A 179
ILE A 129
PRO A 130
LEU A 132
 None
 1.29A 6mkeA-5vkwA:
undetectable		 6mkeA-5vkwA:
11.51