SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vl1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		5 / 12 LEU A 190
PHE A 195
LEU A 289
LEU A 409
TRP A 407
 None
 1.18A 1hrkA-5vl1A:
undetectable		 1hrkA-5vl1A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		5 / 12 TYR A 116
ILE A  43
GLY A 119
VAL A 121
ASP A  58
 None
 1.13A 1kiaB-5vl1A:
undetectable		 1kiaB-5vl1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		3 / 3 TRP A 136
TYR A 116
LEU A  80
 None
 0.97A 1kxhA-5vl1A:
undetectable		 1kxhA-5vl1A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		4 / 6 PRO A 232
PHE A 235
GLU A 199
GLN A 204
 None
 1.47A 1l2iB-5vl1A:
undetectable		 1l2iB-5vl1A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		5 / 12 TYR A 116
ILE A  43
GLY A 119
VAL A 121
SER A 135
 None
 1.21A 1nbhA-5vl1A:
undetectable		 1nbhA-5vl1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		5 / 12 TYR A 116
ILE A  43
GLY A 119
VAL A 121
ASP A  58
 None
 1.10A 1nbhC-5vl1A:
undetectable		 1nbhC-5vl1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		4 / 5 ASP A 453
GLU A 452
LEU A 458
LEU A 455
 None
 1.18A 1np1A-5vl1A:
undetectable		 1np1A-5vl1A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		5 / 10 ALA A 297
GLU A 296
ARG A 192
MET A 470
LEU A 476
 None
 1.36A 1qkuA-5vl1A:
undetectable		 1qkuA-5vl1A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		5 / 10 ALA A 297
GLU A 296
ARG A 192
MET A 470
LEU A 476
 None
 1.37A 1qkuB-5vl1A:
undetectable		 1qkuB-5vl1A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		3 / 3 GLU A 271
THR A 468
LEU A 190
 LYS  A 502 (-3.3A)
None
None
 0.67A 1v8bC-5vl1A:
undetectable		 1v8bC-5vl1A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		4 / 5 ASP A 435
GLY A 360
PRO A 387
VAL A 388
 None
 0.98A 2aoiA-5vl1A:
undetectable		 2aoiA-5vl1A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		4 / 5 ILE A  92
LEU A 102
SER A 101
ARG A  99
 None
 0.95A 2byoA-5vl1A:
1.4		 2byoA-5vl1A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		5 / 12 LEU A 190
PHE A 195
LEU A 289
LEU A 409
TRP A 407
 None
 1.21A 2hrcA-5vl1A:
undetectable		 2hrcA-5vl1A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		5 / 12 LEU A 190
PHE A 195
LEU A 289
LEU A 409
TRP A 407
 None
 1.22A 2hrcB-5vl1A:
undetectable		 2hrcB-5vl1A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		4 / 5 ALA A  90
TRP A 105
LEU A 102
ALA A 133
 None
 1.28A 2jstA-5vl1A:
undetectable
2jstB-5vl1A:
undetectable		 2jstA-5vl1A:
8.65
2jstB-5vl1A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		5 / 10 ALA A 297
GLU A 296
ARG A 192
MET A 470
LEU A 476
 None
 1.17A 2ocfA-5vl1A:
undetectable		 2ocfA-5vl1A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		5 / 12 LEU A 190
PHE A 195
LEU A 289
LEU A 409
TRP A 407
 None
 1.16A 2po5A-5vl1A:
undetectable		 2po5A-5vl1A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		5 / 11 LEU A 190
PHE A 195
LEU A 289
LEU A 409
TRP A 407
 None
 1.16A 2po5B-5vl1A:
undetectable		 2po5B-5vl1A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		5 / 12 LEU A 190
PHE A 195
LEU A 289
LEU A 409
TRP A 407
 None
 1.20A 2po7A-5vl1A:
undetectable		 2po7A-5vl1A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		5 / 12 LEU A 190
PHE A 195
LEU A 289
LEU A 409
TRP A 407
 None
 1.18A 2po7B-5vl1A:
undetectable		 2po7B-5vl1A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		5 / 12 LEU A 190
PHE A 195
LEU A 289
LEU A 409
TRP A 407
 None
 1.37A 2qd4A-5vl1A:
undetectable		 2qd4A-5vl1A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		5 / 12 LEU A 190
PHE A 195
LEU A 289
LEU A 409
TRP A 407
 None
 1.19A 2qd4B-5vl1A:
undetectable		 2qd4B-5vl1A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		4 / 7 TYR A 410
LEU A 377
ASN A 375
TYR A 311
 None
 1.39A 2w98A-5vl1A:
undetectable
2w98B-5vl1A:
undetectable		 2w98A-5vl1A:
20.59
2w98B-5vl1A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		3 / 3 TYR A 323
VAL A 403
THR A 335
 None
 0.83A 2ygnA-5vl1A:
undetectable		 2ygnA-5vl1A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		5 / 9 LEU A 190
LEU A 270
GLU A 249
PHE A 195
VAL A 247
 None
 1.46A 3tmzA-5vl1A:
undetectable		 3tmzA-5vl1A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		4 / 6 LEU A 190
LEU A 289
ILE A 290
MET A 470
 None
 0.99A 4do3B-5vl1A:
undetectable		 4do3B-5vl1A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		4 / 8 ARG A 255
PHE A 267
THR A 418
ARG A 474
 LYS  A 502 (-3.3A)
PGE  A 501 (-3.6A)
PGE  A 501 (-4.2A)
PGE  A 501 (-3.6A)
 0.73A 4k87A-5vl1A:
11.4		 4k87A-5vl1A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		5 / 6 THR A 390
GLY A 362
GLU A 366
TYR A 323
ILE A 334
 None
 1.34A 5kmfA-5vl1A:
undetectable
5kmfC-5vl1A:
undetectable		 5kmfA-5vl1A:
18.58
5kmfC-5vl1A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		5 / 10 ALA A 297
GLU A 296
ARG A 192
MET A 470
LEU A 476
 None
 1.25A 5wgqB-5vl1A:
undetectable		 5wgqB-5vl1A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		7 / 10 ARG A 255
GLU A 257
HIS A 263
PHE A 267
GLY A 471
ARG A 474
ILE A 484
 LYS  A 502 (-3.3A)
None
PGE  A 501 (-4.8A)
PGE  A 501 (-3.6A)
PGE  A 501 ( 4.4A)
PGE  A 501 (-3.6A)
None
 0.77A 6bniA-5vl1A:
43.4		 6bniA-5vl1A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		5 / 10 GLU A 257
HIS A 263
GLU A 415
ARG A 474
ILE A 484
 None
PGE  A 501 (-4.8A)
PGE  A 501 (-4.1A)
PGE  A 501 (-3.6A)
None
 0.93A 6bniA-5vl1A:
43.4		 6bniA-5vl1A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		7 / 10 ARG A 255
GLU A 257
HIS A 263
PHE A 267
GLY A 471
ARG A 474
ILE A 484
 LYS  A 502 (-3.3A)
None
PGE  A 501 (-4.8A)
PGE  A 501 (-3.6A)
PGE  A 501 ( 4.4A)
PGE  A 501 (-3.6A)
None
 0.79A 6bniB-5vl1A:
43.3		 6bniB-5vl1A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 5vl1 LYSINE--TRNA LIGASE
(Mycobacterium
ulcerans) 		5 / 10 GLU A 257
HIS A 263
GLU A 415
ARG A 474
ILE A 484
 None
PGE  A 501 (-4.8A)
PGE  A 501 (-4.1A)
PGE  A 501 (-3.6A)
None
 0.93A 6bniB-5vl1A:
43.3		 6bniB-5vl1A:
10.71