SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vld'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		4 / 7 ARG A 417
TYR A 364
PHE A 360
PHE A 347
 None
 1.22A 1e71M-5vldA:
undetectable		 1e71M-5vldA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		4 / 7 ARG A 417
TYR A 364
PHE A 360
PHE A 347
 None
 1.24A 1e72M-5vldA:
undetectable		 1e72M-5vldA:
21.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		6 / 9 LEU A 174
SER A 176
HIS A 302
ASP A 401
TYR A 402
HIS A 408
 HIS  A 501 (-4.3A)
HIS  A 501 (-3.4A)
NAD  A 502 (-3.9A)
HIS  A 501 ( 2.7A)
HIS  A 501 (-4.4A)
HIS  A 501 ( 3.4A)
 0.35A 1karA-5vldA:
46.3
1karB-5vldA:
45.7		 1karA-5vldA:
48.13
1karB-5vldA:
48.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		6 / 9 LEU A 174
SER A 176
HIS A 302
ASP A 401
TYR A 402
HIS A 408
 HIS  A 501 (-4.3A)
HIS  A 501 (-3.4A)
NAD  A 502 (-3.9A)
HIS  A 501 ( 2.7A)
HIS  A 501 (-4.4A)
HIS  A 501 ( 3.4A)
 0.37A 1karA-5vldA:
46.3
1karB-5vldA:
45.7		 1karA-5vldA:
48.13
1karB-5vldA:
48.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 12 HIS A 135
ASN A 407
TYR A 402
VAL A 183
ALA A 182
 None
None
HIS  A 501 (-4.4A)
None
None
 1.21A 1udtA-5vldA:
undetectable		 1udtA-5vldA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		4 / 6 ALA A 232
TYR A 166
ILE A 230
LEU A 222
 None
NAD  A 502 (-4.3A)
None
None
 0.90A 1xvaA-5vldA:
4.1
1xvaB-5vldA:
4.0		 1xvaA-5vldA:
24.75
1xvaB-5vldA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 12 VAL A 389
ILE A 371
LEU A 369
ILE A 282
ALA A 351
 None
 1.06A 2gj5A-5vldA:
undetectable		 2gj5A-5vldA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		4 / 4 LEU A 179
THR A 177
ILE A 187
HIS A 135
 None
 1.32A 2jfaB-5vldA:
undetectable		 2jfaB-5vldA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 10 ALA A 196
ALA A 224
THR A  93
LEU A 101
VAL A  99
 None
 1.26A 2wuzA-5vldA:
undetectable		 2wuzA-5vldA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 10 ALA A 196
ALA A 224
THR A  93
LEU A 101
VAL A  99
 None
 1.26A 2wuzB-5vldA:
undetectable		 2wuzB-5vldA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_A_DAHA351_1
(PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 9 HIS A 302
SER A 277
VAL A 409
ALA A 274
GLY A 250
 NAD  A 502 (-3.9A)
HIS  A 501 ( 2.6A)
NAD  A 502 (-3.4A)
NAD  A 502 (-3.7A)
NAD  A 502 (-3.0A)
 1.10A 3tehA-5vldA:
undetectable		 3tehA-5vldA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		3 / 3 GLN A 307
PHE A 347
TYR A 364
 None
 0.90A 3ucjB-5vldA:
undetectable		 3ucjB-5vldA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		3 / 3 GLN A 307
PHE A 347
TYR A 364
 None
 0.92A 3ucjA-5vldA:
undetectable		 3ucjA-5vldA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 12 ASN A 320
ASP A 318
ILE A 322
ALA A 293
VAL A 292
 None
 1.16A 4dx5B-5vldA:
undetectable		 4dx5B-5vldA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 12 GLY A 226
GLY A 225
ILE A 230
VAL A  70
ILE A  77
 NAD  A 502 (-3.5A)
NAD  A 502 (-3.9A)
None
None
None
 1.28A 4fglA-5vldA:
2.6
4fglB-5vldA:
undetectable		 4fglA-5vldA:
21.71
4fglB-5vldA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 12 VAL A 167
PRO A 249
GLU A 367
HIS A 368
SER A 388
 None
NAD  A 502 (-4.1A)
HIS  A 501 ( 2.7A)
HIS  A 501 (-3.9A)
None
 1.14A 4hvcA-5vldA:
2.3		 4hvcA-5vldA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		3 / 4 SER A 426
GLY A 387
GLU A 384
 None
 0.57A 4juoA-5vldA:
undetectable
4juoC-5vldA:
undetectable		 4juoA-5vldA:
24.43
4juoC-5vldA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		3 / 3 GLU A 367
THR A 177
HIS A 408
 HIS  A 501 ( 2.7A)
None
HIS  A 501 ( 3.4A)
 0.86A 4q15A-5vldA:
3.0		 4q15A-5vldA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		3 / 3 GLU A 367
THR A 177
HIS A 408
 HIS  A 501 ( 2.7A)
None
HIS  A 501 ( 3.4A)
 0.83A 4q15B-5vldA:
2.8		 4q15B-5vldA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 12 GLY A 217
PHE A 427
GLY A 189
ILE A 160
ASN A 161
 None
 1.20A 4rtsA-5vldA:
3.7		 4rtsA-5vldA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 12 ASN A 320
ASP A 318
ILE A 322
ALA A 293
VAL A 292
 None
 1.16A 4u8vB-5vldA:
undetectable		 4u8vB-5vldA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 12 ASN A 320
ASP A 318
ILE A 322
ALA A 293
VAL A 292
 None
 1.15A 4u95B-5vldA:
undetectable		 4u95B-5vldA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 11 LEU A 297
GLN A 299
ALA A 300
HIS A 408
VAL A 279
 None
HIS  A 501 ( 3.3A)
None
HIS  A 501 ( 3.4A)
None
 1.40A 4uuuA-5vldA:
undetectable
4uuuB-5vldA:
undetectable		 4uuuA-5vldA:
17.73
4uuuB-5vldA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 10 GLY A 421
VAL A 422
THR A 406
VAL A 409
HIS A 135
 None
None
None
NAD  A 502 (-3.4A)
None
 1.04A 4yb6A-5vldA:
undetectable
4yb6E-5vldA:
undetectable		 4yb6A-5vldA:
22.10
4yb6E-5vldA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 10 GLY A 421
VAL A 422
THR A 406
VAL A 409
HIS A 135
 None
None
None
NAD  A 502 (-3.4A)
None
 1.05A 4yb6B-5vldA:
undetectable
4yb6C-5vldA:
undetectable		 4yb6B-5vldA:
22.10
4yb6C-5vldA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 10 GLY A 421
VAL A 422
THR A 406
VAL A 409
HIS A 135
 None
None
None
NAD  A 502 (-3.4A)
None
 1.03A 4yb6C-5vldA:
undetectable
4yb6F-5vldA:
undetectable		 4yb6C-5vldA:
22.10
4yb6F-5vldA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 10 HIS A 135
GLY A 421
VAL A 422
THR A 406
VAL A 409
 None
None
None
None
NAD  A 502 (-3.4A)
 1.01A 4yb6A-5vldA:
undetectable
4yb6D-5vldA:
undetectable		 4yb6A-5vldA:
22.10
4yb6D-5vldA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 10 HIS A 135
GLY A 421
VAL A 422
THR A 406
VAL A 409
 None
None
None
None
NAD  A 502 (-3.4A)
 1.03A 4yb6D-5vldA:
undetectable
4yb6E-5vldA:
1.3		 4yb6D-5vldA:
22.10
4yb6E-5vldA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 10 HIS A 135
GLY A 421
VAL A 422
THR A 406
VAL A 409
 None
None
None
None
NAD  A 502 (-3.4A)
 1.05A 4yb6B-5vldA:
undetectable
4yb6F-5vldA:
undetectable		 4yb6B-5vldA:
22.10
4yb6F-5vldA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 12 VAL A 167
PRO A 249
GLU A 367
HIS A 368
SER A 388
 None
NAD  A 502 (-4.1A)
HIS  A 501 ( 2.7A)
HIS  A 501 (-3.9A)
None
 1.19A 4ydqA-5vldA:
2.9		 4ydqA-5vldA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		4 / 8 HIS A 302
SER A 388
HIS A 408
SER A 176
 NAD  A 502 (-3.9A)
None
HIS  A 501 ( 3.4A)
HIS  A 501 (-3.4A)
 0.99A 5m8rB-5vldA:
undetectable		 5m8rB-5vldA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 12 VAL A 167
PRO A 249
GLU A 367
HIS A 368
SER A 388
 None
NAD  A 502 (-4.1A)
HIS  A 501 ( 2.7A)
HIS  A 501 (-3.9A)
None
 1.28A 5xioA-5vldA:
2.4		 5xioA-5vldA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 12 VAL A 167
PRO A 249
GLU A 367
HIS A 368
SER A 388
 None
NAD  A 502 (-4.1A)
HIS  A 501 ( 2.7A)
HIS  A 501 (-3.9A)
None
 1.18A 5xiqA-5vldA:
2.6		 5xiqA-5vldA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 12 VAL A 167
PRO A 249
GLU A 367
HIS A 368
SER A 388
 None
NAD  A 502 (-4.1A)
HIS  A 501 ( 2.7A)
HIS  A 501 (-3.9A)
None
 1.16A 5xiqB-5vldA:
2.7		 5xiqB-5vldA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 12 VAL A 167
PRO A 249
GLU A 367
HIS A 368
SER A 388
 None
NAD  A 502 (-4.1A)
HIS  A 501 ( 2.7A)
HIS  A 501 (-3.9A)
None
 1.22A 5xiqC-5vldA:
2.6		 5xiqC-5vldA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 12 GLY A 248
VAL A 254
GLY A 217
ASN A 197
ASN A 251
 None
NAD  A 502 ( 4.9A)
None
None
NAD  A 502 (-3.2A)
 1.14A 6gngA-5vldA:
undetectable		 6gngA-5vldA:
22.10