SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vlj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 5vlj NUCLEAR DISTRIBUTION
PROTEIN PAC1
(Saccharomyces
cerevisiae) 		5 / 12 ILE B 169
LEU B 179
LEU B 194
ILE B 222
PHE B 208
 None
 1.24A 1fmlB-5vljB:
undetectable		 1fmlB-5vljB:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U65_A_CP0A1000_1
(ACETYLCHOLINESTERASE)		 5vlj NUCLEAR DISTRIBUTION
PROTEIN PAC1
(Saccharomyces
cerevisiae) 		5 / 11 GLN B 245
GLU B 155
LEU B 207
ASP B 205
HIS B 176
 None
 1.31A 1u65A-5vljB:
undetectable		 1u65A-5vljB:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 5vlj NUCLEAR DISTRIBUTION
PROTEIN PAC1
(Saccharomyces
cerevisiae) 		4 / 7 ILE B 340
SER B 302
ILE B 387
PHE B 407
 None
 0.92A 2q6hA-5vljB:
undetectable		 2q6hA-5vljB:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 5vlj NUCLEAR DISTRIBUTION
PROTEIN PAC1
(Saccharomyces
cerevisiae) 		4 / 6 ILE B 340
SER B 302
ILE B 387
PHE B 407
 None
 0.94A 2q72A-5vljB:
undetectable		 2q72A-5vljB:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 5vlj NUCLEAR DISTRIBUTION
PROTEIN PAC1
(Saccharomyces
cerevisiae) 		4 / 7 ILE B 340
SER B 302
ILE B 387
PHE B 407
 None
 0.91A 2qb4A-5vljB:
undetectable		 2qb4A-5vljB:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 5vlj NUCLEAR DISTRIBUTION
PROTEIN PAC1
(Saccharomyces
cerevisiae) 		3 / 3 PHE B 182
SER B 149
LEU B 151
 None
 0.66A 2w1bA-5vljB:
undetectable		 2w1bA-5vljB:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IEO_A_AMJA300_0
(CARBONIC ANHYDRASE 2)		 5vlj NUCLEAR DISTRIBUTION
PROTEIN PAC1
(Saccharomyces
cerevisiae) 		4 / 4 ILE B 261
GLN B 263
VAL B 206
PHE B 284
 None
 1.05A 3ieoA-5vljB:
undetectable		 3ieoA-5vljB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 5vlj NUCLEAR DISTRIBUTION
PROTEIN PAC1
(Saccharomyces
cerevisiae) 		5 / 9 ASP B 351
ILE B 355
GLY B 447
VAL B 374
ILE B 425
 None
 1.08A 3nuoA-5vljB:
undetectable		 3nuoA-5vljB:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5vlj NUCLEAR DISTRIBUTION
PROTEIN PAC1
(Saccharomyces
cerevisiae) 		5 / 11 ASN B 490
SER B 149
PHE B 182
VAL B 172
ILE B 152
 None
 1.46A 4claA-5vljB:
undetectable		 4claA-5vljB:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 5vlj NUCLEAR DISTRIBUTION
PROTEIN PAC1
(Saccharomyces
cerevisiae) 		4 / 8 ILE B 152
ILE B 189
ALA B 181
VAL B 158
 None
 0.77A 4jltA-5vljB:
undetectable		 4jltA-5vljB:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 5vlj NUCLEAR DISTRIBUTION
PROTEIN PAC1
(Saccharomyces
cerevisiae) 		4 / 5 GLU B 386
ARG B 408
PRO B 390
SER B 331
 None
 1.08A 4k17B-5vljB:
2.7		 4k17B-5vljB:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 5vlj NUCLEAR DISTRIBUTION
PROTEIN PAC1
(Saccharomyces
cerevisiae) 		4 / 7 ASP B 379
THR B 381
PHE B 338
HIS B 336
 None
 1.33A 4o4dA-5vljB:
undetectable		 4o4dA-5vljB:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5vlj NUCLEAR DISTRIBUTION
PROTEIN PAC1
(Saccharomyces
cerevisiae) 		4 / 6 PHE B 407
LEU B 389
ASN B 401
PRO B 402
 None
 1.45A 4yv5A-5vljB:
undetectable		 4yv5A-5vljB:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 5vlj NUCLEAR DISTRIBUTION
PROTEIN PAC1
(Saccharomyces
cerevisiae) 		5 / 9 ASP B 351
ILE B 355
GLY B 447
VAL B 374
ILE B 425
 None
 1.15A 5kr0A-5vljB:
undetectable		 5kr0A-5vljB:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5vlj NUCLEAR DISTRIBUTION
PROTEIN PAC1
(Saccharomyces
cerevisiae) 		5 / 12 ILE B 310
ILE B 281
VAL B 305
ASN B 266
ILE B 261
 None
 1.15A 5lg3J-5vljB:
undetectable		 5lg3J-5vljB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 5vlj NUCLEAR DISTRIBUTION
PROTEIN PAC1
(Saccharomyces
cerevisiae) 		4 / 5 MET B 480
ASN B 473
VAL B 468
LEU B 466
 None
 1.46A 5xdhD-5vljB:
undetectable		 5xdhD-5vljB:
11.40