SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vlq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 5vlq LOC100158544 PROTEIN
(Xenopus
tropicalis) 		3 / 3 ALA A  30
VAL A  48
TRP A  47
 None
 0.97A 1grmA-5vlqA:
undetectable		 1grmA-5vlqA:
3.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 5vlq LOC100158544 PROTEIN
(Xenopus
tropicalis) 		3 / 3 ALA A  30
VAL A  48
TRP A  47
 None
 0.97A 1grmB-5vlqA:
undetectable		 1grmB-5vlqA:
3.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 5vlq LOC100158544 PROTEIN
(Xenopus
tropicalis) 		3 / 3 ALA A 473
VAL A 476
TRP A 471
 None
 0.95A 2izqA-5vlqA:
undetectable
2izqB-5vlqA:
undetectable		 2izqA-5vlqA:
3.21
2izqB-5vlqA:
3.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5vlq LOC100158544 PROTEIN
(Xenopus
tropicalis) 		5 / 11 VAL A 549
ILE A  38
LEU A  42
PHE A 114
THR A 395
 None
 1.29A 3fl9C-5vlqA:
undetectable		 3fl9C-5vlqA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5vlq LOC100158544 PROTEIN
(Xenopus
tropicalis) 		5 / 12 PHE A 382
PRO A 448
PHE A 514
ILE A 475
LEU A 458
 None
 1.10A 3iv6C-5vlqA:
undetectable		 3iv6C-5vlqA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 5vlq LOC100158544 PROTEIN
(Xenopus
tropicalis) 		5 / 11 ILE A 521
PHE A 143
ALA A 486
ILE A 402
VAL A 394
 None
 0.96A 3kw4A-5vlqA:
undetectable		 3kw4A-5vlqA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 5vlq LOC100158544 PROTEIN
(Xenopus
tropicalis) 		4 / 8 PRO A 516
LEU A 462
VAL A 474
HIS A 469
 None
 1.22A 4qknA-5vlqA:
undetectable		 4qknA-5vlqA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 5vlq LOC100158544 PROTEIN
(Xenopus
tropicalis) 		4 / 6 PHE A 392
GLY A 505
TYR A 504
ALA A 523
 None
 1.08A 4yshB-5vlqA:
undetectable		 4yshB-5vlqA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 5vlq LOC100158544 PROTEIN
(Xenopus
tropicalis) 		5 / 12 LEU A 393
ILE A 548
ASP A 559
GLY A 561
PHE A 563
 None
 1.25A 5j7wC-5vlqA:
undetectable		 5j7wC-5vlqA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5vlq LOC100158544 PROTEIN
(Xenopus
tropicalis) 		4 / 4 SER A 524
ALA A 523
GLN A 520
THR A 144
 None
None
ANP  A 601 (-3.3A)
None
 1.41A 5n0rA-5vlqA:
undetectable		 5n0rA-5vlqA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5vlq LOC100158544 PROTEIN
(Xenopus
tropicalis) 		4 / 4 SER A 524
ALA A 523
GLN A 520
THR A 144
 None
None
ANP  A 601 (-3.3A)
None
 1.39A 5n0sA-5vlqA:
undetectable		 5n0sA-5vlqA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5vlq LOC100158544 PROTEIN
(Xenopus
tropicalis) 		4 / 5 SER A 524
ALA A 523
GLN A 520
THR A 144
 None
None
ANP  A 601 (-3.3A)
None
 1.39A 5n0tA-5vlqA:
undetectable		 5n0tA-5vlqA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5vlq LOC100158544 PROTEIN
(Xenopus
tropicalis) 		4 / 4 SER A 524
ALA A 523
GLN A 520
THR A 144
 None
None
ANP  A 601 (-3.3A)
None
 1.41A 5n0wA-5vlqA:
undetectable		 5n0wA-5vlqA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5vlq LOC100158544 PROTEIN
(Xenopus
tropicalis) 		4 / 4 SER A 524
ALA A 523
GLN A 520
THR A 144
 None
None
ANP  A 601 (-3.3A)
None
 1.44A 5n0xA-5vlqA:
undetectable		 5n0xA-5vlqA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 5vlq LOC100158544 PROTEIN
(Xenopus
tropicalis) 		5 / 12 PHE A 392
ILE A 483
THR A 545
PHE A 143
ALA A 490
 None
 1.22A 5vcgA-5vlqA:
undetectable		 5vcgA-5vlqA:
21.24