SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vm1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		5 / 10 THR A 245
PHE A 252
ALA A 240
LEU A 381
VAL A 276
 None
 1.21A 1claA-5vm1A:
undetectable		 1claA-5vm1A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		4 / 6 LEU A 261
ILE A 293
GLU A 337
ASP A 376
 None
 1.10A 1ditH-5vm1A:
undetectable
1ditP-5vm1A:
undetectable		 1ditH-5vm1A:
20.41
1ditP-5vm1A:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		4 / 7 GLN A 312
ASP A 315
LEU A 417
SER A 398
 None
 1.00A 1ig3A-5vm1A:
undetectable
1ig3B-5vm1A:
undetectable		 1ig3A-5vm1A:
19.23
1ig3B-5vm1A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		3 / 3 ALA A 141
VAL A 136
TRP A 135
 None
 0.85A 1kqeA-5vm1A:
undetectable
1kqeE-5vm1A:
undetectable		 1kqeA-5vm1A:
5.70
1kqeE-5vm1A:
5.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		3 / 3 ALA A 141
VAL A 136
TRP A 135
 None
 0.87A 1kqeB-5vm1A:
undetectable
1kqeD-5vm1A:
undetectable		 1kqeB-5vm1A:
5.70
1kqeD-5vm1A:
5.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		3 / 3 TRP A 135
ALA A 141
VAL A 136
 None
 0.87A 1kqeB-5vm1A:
undetectable
1kqeD-5vm1A:
undetectable		 1kqeB-5vm1A:
5.70
1kqeD-5vm1A:
5.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		3 / 3 TRP A 135
ALA A 141
VAL A 136
 None
 0.87A 1kqeA-5vm1A:
undetectable
1kqeE-5vm1A:
undetectable		 1kqeA-5vm1A:
5.70
1kqeE-5vm1A:
5.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		5 / 12 GLN A  78
VAL A  12
GLY A  11
ALA A 429
ILE A  73
 None
 0.97A 1kxhA-5vm1A:
undetectable		 1kxhA-5vm1A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		3 / 3 ALA A 141
VAL A 136
TRP A 135
 None
 0.89A 1micA-5vm1A:
undetectable
1micB-5vm1A:
undetectable		 1micA-5vm1A:
8.59
1micB-5vm1A:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		5 / 11 LEU A  31
VAL A  12
GLY A  29
THR A  54
ILE A  49
 None
 1.11A 1phgA-5vm1A:
undetectable		 1phgA-5vm1A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 5vm1 XYLULOKINASE
(Brucella
ovis) 		5 / 12 ALA A 430
ALA A 426
LEU A  31
GLY A  74
LEU A   7
 None
 1.15A 1qabF-5vm1A:
undetectable		 1qabF-5vm1A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		4 / 8 VAL A  12
GLY A  29
THR A  54
ILE A  49
 None
 0.78A 2a1mB-5vm1A:
undetectable		 2a1mB-5vm1A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		5 / 12 LEU A 157
LEU A 161
GLY A   4
ASP A 422
ALA A  26
 None
 1.29A 2bm9B-5vm1A:
undetectable		 2bm9B-5vm1A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		4 / 7 GLY A 256
ALA A 296
ALA A 297
TRP A 403
 None
 0.44A 2ha4B-5vm1A:
undetectable		 2ha4B-5vm1A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		5 / 9 GLY A 234
LEU A 432
SER A  76
ASP A   6
ASP A 235
 None
 1.40A 2j2pB-5vm1A:
undetectable
2j2pC-5vm1A:
undetectable		 2j2pB-5vm1A:
19.65
2j2pC-5vm1A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		5 / 12 ILE A 388
LEU A 381
GLY A 385
ALA A 264
ALA A 263
 None
 0.81A 2oc8A-5vm1A:
undetectable		 2oc8A-5vm1A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		5 / 11 LEU A  92
ILE A 147
ALA A 137
PHE A 144
LEU A 195
 None
 1.18A 2qjuA-5vm1A:
undetectable		 2qjuA-5vm1A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		4 / 8 GLY A  74
VAL A 229
LEU A 161
TRP A 221
 None
 0.90A 3bgdB-5vm1A:
undetectable		 3bgdB-5vm1A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		3 / 3 CYH A 280
PRO A 270
ASP A 179
 None
 0.47A 3hlwB-5vm1A:
undetectable		 3hlwB-5vm1A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		5 / 9 ILE A  49
LEU A   7
ARG A  93
LEU A  92
GLY A  81
 None
 1.49A 3nxuB-5vm1A:
undetectable		 3nxuB-5vm1A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		5 / 12 LEU A 178
HIS A 281
GLY A 232
SER A 207
LEU A 203
 None
 1.39A 3okxA-5vm1A:
undetectable		 3okxA-5vm1A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		5 / 10 VAL A 413
ALA A 393
VAL A 253
ILE A 407
ILE A 388
 None
 1.20A 3retA-5vm1A:
undetectable
3retB-5vm1A:
undetectable		 3retA-5vm1A:
12.66
3retB-5vm1A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		5 / 12 ILE A 407
LEU A 411
ALA A 416
THR A 454
VAL A 413
 None
 1.02A 3rukA-5vm1A:
undetectable		 3rukA-5vm1A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		5 / 12 ILE A 407
LEU A 411
ALA A 416
THR A 454
VAL A 413
 None
 0.99A 3rukB-5vm1A:
undetectable		 3rukB-5vm1A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		5 / 12 HIS A  80
LEU A 152
ALA A 237
GLY A  77
GLY A   8
 None
 1.28A 4hfpB-5vm1A:
undetectable		 4hfpB-5vm1A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		5 / 12 VAL A 136
ALA A  82
LEU A  85
LEU A  92
LEU A 195
 None
 1.05A 4i1rA-5vm1A:
undetectable		 4i1rA-5vm1A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		4 / 5 GLY A 242
SER A 239
ALA A 238
PHE A 427
 None
 1.00A 4m93B-5vm1A:
undetectable
4m93C-5vm1A:
undetectable		 4m93B-5vm1A:
20.82
4m93C-5vm1A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		4 / 6 ASP A 171
ASP A 168
ALA A 230
ASP A 155
 None
 1.21A 4mdaA-5vm1A:
1.6		 4mdaA-5vm1A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		3 / 3 CYH A 280
PRO A 270
ASP A 179
 None
 0.48A 4pm5A-5vm1A:
undetectable		 4pm5A-5vm1A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		5 / 9 ALA A 429
ALA A 238
ALA A 282
SER A 170
ALA A 230
 None
 1.34A 4twdA-5vm1A:
undetectable
4twdB-5vm1A:
undetectable
4twdC-5vm1A:
undetectable
4twdD-5vm1A:
undetectable
4twdE-5vm1A:
undetectable		 4twdA-5vm1A:
20.82
4twdB-5vm1A:
20.82
4twdC-5vm1A:
20.82
4twdD-5vm1A:
20.82
4twdE-5vm1A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		5 / 8 ALA A 230
ALA A 429
ALA A 238
ALA A 282
SER A 170
 None
 1.36A 4twdF-5vm1A:
undetectable
4twdG-5vm1A:
undetectable
4twdH-5vm1A:
undetectable
4twdI-5vm1A:
undetectable
4twdJ-5vm1A:
undetectable		 4twdF-5vm1A:
20.82
4twdG-5vm1A:
20.82
4twdH-5vm1A:
20.82
4twdI-5vm1A:
20.82
4twdJ-5vm1A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		4 / 5 GLY A 127
TYR A 104
SER A 103
ASP A 100
 None
 1.26A 4xueA-5vm1A:
undetectable		 4xueA-5vm1A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		5 / 12 GLY A 428
PHE A 423
GLY A 232
GLY A 244
HIS A 281
 None
 1.07A 5gwxA-5vm1A:
undetectable		 5gwxA-5vm1A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5vm1 XYLULOKINASE
(Brucella
ovis) 		5 / 12 ALA A 299
ASP A 315
PRO A 311
GLY A 397
SER A 398
 None
 1.20A 5hfjB-5vm1A:
undetectable		 5hfjB-5vm1A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		4 / 4 CYH A 446
LEU A 432
LEU A 283
ALA A 282
 None
 1.13A 5hpuA-5vm1A:
undetectable
5hpuB-5vm1A:
undetectable		 5hpuA-5vm1A:
4.72
5hpuB-5vm1A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		5 / 12 THR A 120
SER A 172
GLY A 174
THR A 129
MET A  79
 None
 1.28A 5lf3b-5vm1A:
undetectable		 5lf3b-5vm1A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		4 / 4 GLN A 269
GLN A 289
PRO A 248
ALA A 263
 None
 1.31A 5odcA-5vm1A:
undetectable
5odcG-5vm1A:
undetectable		 5odcA-5vm1A:
22.52
5odcG-5vm1A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_G_ACTG704_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		4 / 5 PRO A 248
ALA A 263
GLN A 269
GLN A 289
 None
 1.31A 5odcA-5vm1A:
undetectable
5odcG-5vm1A:
undetectable		 5odcA-5vm1A:
22.52
5odcG-5vm1A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		5 / 10 GLY A 397
TRP A 403
LEU A 391
ILE A 455
ALA A 393
 None
 1.05A 5vm8B-5vm1A:
undetectable		 5vm8B-5vm1A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		5 / 12 GLY A 206
ASP A 168
ASP A 171
LEU A 432
ALA A 429
 None
 0.93A 6bq4A-5vm1A:
undetectable		 6bq4A-5vm1A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		5 / 12 GLY A 206
ASP A 168
ASP A 171
LEU A 432
ALA A 429
 None
 0.96A 6bq4B-5vm1A:
undetectable		 6bq4B-5vm1A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 5vm1 XYLULOKINASE
(Brucella
ovis) 		5 / 12 ASP A 466
ASP A 376
PHE A 372
PRO A 332
GLY A 348
 None
 1.41A 6gnfA-5vm1A:
undetectable		 6gnfA-5vm1A:
23.74