SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vm2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		4 / 8 GLY A  37
GLY A  64
MET A 115
LEU A 129
 None
 0.86A 1aegA-5vm2A:
undetectable		 1aegA-5vm2A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.77A 1fb7A-5vm2A:
undetectable		 1fb7A-5vm2A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.86A 1hsgB-5vm2A:
undetectable		 1hsgB-5vm2A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.82A 1ohrA-5vm2A:
undetectable		 1ohrA-5vm2A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.81A 1sdtB-5vm2A:
undetectable		 1sdtB-5vm2A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.92A 1sduB-5vm2A:
undetectable		 1sduB-5vm2A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 THR A 145
VAL A  71
VAL A  87
GLU A  34
ASP A  85
 None
 1.28A 1t6zB-5vm2A:
2.0		 1t6zB-5vm2A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		4 / 5 PRO A 255
VAL A 258
VAL A 285
ILE A 264
 None
 1.06A 1z2bC-5vm2A:
4.1		 1z2bC-5vm2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 VAL A 299
VAL A 151
PHE A 309
GLU A 302
 None
 0.94A 1zzrA-5vm2A:
undetectable
1zzrB-5vm2A:
undetectable		 1zzrA-5vm2A:
21.59
1zzrB-5vm2A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 10 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.83A 2aquA-5vm2A:
undetectable		 2aquA-5vm2A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.83A 2aquB-5vm2A:
undetectable		 2aquB-5vm2A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.85A 2avoB-5vm2A:
undetectable		 2avoB-5vm2A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_3
(POL POLYPROTEIN)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.87A 2avvE-5vm2A:
undetectable		 2avvE-5vm2A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.85A 2bpxB-5vm2A:
undetectable		 2bpxB-5vm2A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 ARG A  86
ASN A 142
ASP A 141
GLY A 148
 None
 1.05A 2f6dA-5vm2A:
undetectable		 2f6dA-5vm2A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.83A 2f80B-5vm2A:
undetectable		 2f80B-5vm2A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.80A 2f81B-5vm2A:
undetectable		 2f81B-5vm2A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.88A 2fxeB-5vm2A:
undetectable		 2fxeB-5vm2A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_1
(PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.83A 2hs2A-5vm2A:
undetectable		 2hs2A-5vm2A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_2
(PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.78A 2hs2B-5vm2A:
undetectable		 2hs2B-5vm2A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.80A 2ienB-5vm2A:
undetectable		 2ienB-5vm2A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.92A 2o4sA-5vm2A:
undetectable		 2o4sA-5vm2A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_2
(PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.90A 2o4sB-5vm2A:
undetectable		 2o4sB-5vm2A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.75A 2pymA-5vm2A:
undetectable		 2pymA-5vm2A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.75A 2pynA-5vm2A:
undetectable		 2pynA-5vm2A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_2
(PROTEASE RETROPEPSIN)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.77A 2qhcB-5vm2A:
undetectable		 2qhcB-5vm2A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.78A 2r5qB-5vm2A:
undetectable		 2r5qB-5vm2A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		4 / 4 SER A  41
GLY A  40
GLY A  64
GLY A  37
 CSO  A  39 ( 4.5A)
CSO  A  39 ( 2.4A)
None
None
 0.90A 3bogB-5vm2A:
undetectable
3bogD-5vm2A:
undetectable		 3bogB-5vm2A:
undetectable
3bogD-5vm2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.89A 3cywA-5vm2A:
undetectable		 3cywA-5vm2A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.85A 3cywB-5vm2A:
undetectable		 3cywB-5vm2A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.83A 3cyxA-5vm2A:
undetectable		 3cyxA-5vm2A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_2
(HIV-1 PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.82A 3d20B-5vm2A:
undetectable		 3d20B-5vm2A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 VAL A 299
VAL A 151
PHE A 309
GLU A 302
 None
 0.94A 3dqrA-5vm2A:
undetectable
3dqrB-5vm2A:
undetectable		 3dqrA-5vm2A:
21.49
3dqrB-5vm2A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 PHE A 309
GLU A 302
VAL A 299
VAL A 151
 None
 0.94A 3dqrA-5vm2A:
undetectable
3dqrB-5vm2A:
undetectable		 3dqrA-5vm2A:
21.49
3dqrB-5vm2A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 10 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.87A 3ekyA-5vm2A:
undetectable		 3ekyA-5vm2A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.73A 3em4A-5vm2A:
undetectable		 3em4A-5vm2A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.80A 3em4U-5vm2A:
undetectable		 3em4U-5vm2A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 LYS A 340
ILE A  89
PHE A 135
 CSO  A  39 ( 2.6A)
None
None
 0.61A 3j7zS-5vm2A:
undetectable
3j7za-5vm2A:
undetectable		 3j7zS-5vm2A:
15.27
3j7za-5vm2A:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 9 LEU A 175
THR A 244
GLY A 157
ALA A 161
ILE A 196
 None
 1.47A 3jusB-5vm2A:
undetectable		 3jusB-5vm2A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_1
(GAG-POL POLYPROTEIN)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.74A 3jvyA-5vm2A:
undetectable		 3jvyA-5vm2A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_2
(GAG-POL POLYPROTEIN)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.80A 3jvyB-5vm2A:
undetectable		 3jvyB-5vm2A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 PHE A 309
GLU A 302
VAL A 299
VAL A 151
 None
 0.93A 3jx2A-5vm2A:
undetectable
3jx2B-5vm2A:
undetectable		 3jx2A-5vm2A:
21.49
3jx2B-5vm2A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_3
(HIV-1 PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.81A 3k4vD-5vm2A:
undetectable		 3k4vD-5vm2A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.83A 3lzsA-5vm2A:
undetectable		 3lzsA-5vm2A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.92A 3lzsB-5vm2A:
undetectable		 3lzsB-5vm2A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.91A 3lzuA-5vm2A:
undetectable		 3lzuA-5vm2A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_2
(PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.83A 3ndtD-5vm2A:
undetectable		 3ndtD-5vm2A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_1
(PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.82A 3nduA-5vm2A:
undetectable		 3nduA-5vm2A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.79A 3nduB-5vm2A:
undetectable		 3nduB-5vm2A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_2
(PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.82A 3nduD-5vm2A:
undetectable		 3nduD-5vm2A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_1
(PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.79A 3ndwA-5vm2A:
undetectable		 3ndwA-5vm2A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.82A 3ndxB-5vm2A:
undetectable		 3ndxB-5vm2A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 PHE A 309
GLU A 302
VAL A 299
VAL A 151
 None
 0.92A 3nlpA-5vm2A:
undetectable
3nlpB-5vm2A:
undetectable		 3nlpA-5vm2A:
21.49
3nlpB-5vm2A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 VAL A 299
VAL A 151
PHE A 309
GLU A 302
 None
 0.93A 3nlrA-5vm2A:
undetectable
3nlrB-5vm2A:
undetectable		 3nlrA-5vm2A:
21.49
3nlrB-5vm2A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		4 / 8 PHE A 309
GLU A 302
VAL A 299
VAL A 151
 None
 0.92A 3nlrA-5vm2A:
undetectable
3nlrB-5vm2A:
undetectable		 3nlrA-5vm2A:
21.49
3nlrB-5vm2A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.81A 3oxcA-5vm2A:
undetectable		 3oxcA-5vm2A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_2
(PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.82A 3pwmB-5vm2A:
undetectable		 3pwmB-5vm2A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_1
(PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.85A 3pwrA-5vm2A:
undetectable		 3pwrA-5vm2A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_1
(PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.81A 3tkgA-5vm2A:
undetectable		 3tkgA-5vm2A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.83A 3tkgC-5vm2A:
undetectable		 3tkgC-5vm2A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.86A 3tkwA-5vm2A:
undetectable		 3tkwA-5vm2A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 VAL A 299
VAL A 151
PHE A 309
GLU A 302
 None
 0.92A 4cx4A-5vm2A:
undetectable
4cx4B-5vm2A:
undetectable		 4cx4A-5vm2A:
21.49
4cx4B-5vm2A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_1
(PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.92A 4hlaA-5vm2A:
undetectable		 4hlaA-5vm2A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.92A 4hlaB-5vm2A:
undetectable		 4hlaB-5vm2A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 PHE A 309
GLU A 302
VAL A 299
VAL A 151
 None
 0.91A 5addA-5vm2A:
undetectable
5addB-5vm2A:
undetectable		 5addA-5vm2A:
21.49
5addB-5vm2A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 9 HIS A 127
ARG A 122
ILE A  89
GLU A 152
GLU A  34
 None
None
None
MG  A 401 (-2.4A)
None
 1.40A 5igzA-5vm2A:
undetectable		 5igzA-5vm2A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 GLY A  96
CYH A 101
CYH A  98
 ZN  A 402 ( 4.7A)
ZN  A 402 (-2.4A)
ZN  A 402 (-2.3A)
 0.96A 5inzB-5vm2A:
undetectable		 5inzB-5vm2A:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 SER A 247
THR A 225
ILE A 226
LEU A 257
 None
 0.89A 5te8A-5vm2A:
undetectable		 5te8A-5vm2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.84A 6dh6A-5vm2A:
undetectable		 6dh6A-5vm2A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_0
(HIV-1 PROTEASE)		 5vm2 ALCOHOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 237
ALA A 238
ASP A 239
VAL A 199
ILE A 173
 None
 0.86A 6dj1A-5vm2A:
undetectable		 6dj1A-5vm2A:
10.66