SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vm8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)
5vm8 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Neisseria
gonorrhoeae)
4 / 6 ASP A  90
LEU A  93
GLU A 194
ARG A 127
None
1.02A 1mt1A-5vm8A:
undetectable
1mt1F-5vm8A:
undetectable
1mt1A-5vm8A:
13.60
1mt1F-5vm8A:
20.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)
5vm8 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Neisseria
gonorrhoeae)
5 / 12 VAL A 191
GLY A 192
GLY A 196
LEU A 220
ALA A 225
None
0.64A 2egvB-5vm8A:
25.5
2egvB-5vm8A:
31.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)
5vm8 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Neisseria
gonorrhoeae)
3 / 3 ARG A 124
ARG A 127
TRP A 128
None
1.45A 4b7nA-5vm8A:
undetectable
4b7nA-5vm8A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)
5vm8 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Neisseria
gonorrhoeae)
3 / 3 ARG A 124
ARG A 127
TRP A 128
None
1.47A 4cpzC-5vm8A:
undetectable
4cpzC-5vm8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)
5vm8 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Neisseria
gonorrhoeae)
3 / 3 ARG A 124
ARG A 127
TRP A 128
None
1.35A 4cpzE-5vm8A:
undetectable
4cpzE-5vm8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)
5vm8 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Neisseria
gonorrhoeae)
3 / 3 ARG A 124
ARG A 127
TRP A 128
None
1.46A 4cpzF-5vm8A:
undetectable
4cpzF-5vm8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)
5vm8 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Neisseria
gonorrhoeae)
3 / 3 ARG A 124
ARG A 127
TRP A 128
None
1.47A 4cpzG-5vm8A:
undetectable
4cpzG-5vm8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)
5vm8 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Neisseria
gonorrhoeae)
3 / 3 ARG A 124
ARG A 127
TRP A 128
None
1.49A 4cpzH-5vm8A:
undetectable
4cpzH-5vm8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
5vm8 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Neisseria
gonorrhoeae)
4 / 6 CYH A 136
GLY A  44
GLY A  42
ASP A  41
None
0.93A 5a06D-5vm8A:
2.8
5a06D-5vm8A:
21.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
5vm8 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Neisseria
gonorrhoeae)
5 / 10 GLY A 192
GLY A 196
TRP A 197
LEU A 215
ALA A 225
None
0.96A 5vm8B-5vm8A:
34.1
5vm8B-5vm8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
5vm8 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Neisseria
gonorrhoeae)
6 / 10 MET A 169
VAL A 191
GLY A 192
GLY A 196
TRP A 197
LEU A 215
None
1.01A 5vm8B-5vm8A:
34.1
5vm8B-5vm8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)
5vm8 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Neisseria
gonorrhoeae)
4 / 8 TRP A 128
ARG A 127
ILE A 150
PRO A 106
None
0.98A 6a4iA-5vm8A:
undetectable
6a4iA-5vm8A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
5vm8 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Neisseria
gonorrhoeae)
4 / 8 ILE A 131
GLN A  94
VAL A  97
ILE A 104
None
0.92A 6cduG-5vm8A:
undetectable
6cduH-5vm8A:
undetectable
6cduG-5vm8A:
20.99
6cduH-5vm8A:
20.99