SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vmm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5vmm IRON-REGULATED CELL
WALL-ANCHORED
PROTEIN
(Staphylococcus
aureus) 		5 / 12 PHE H 225
VAL H 200
THR H 252
ALA H 174
PHE H 153
 None
 1.33A 3apxA-5vmmH:
undetectable		 3apxA-5vmmH:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5vmm IRON-REGULATED CELL
WALL-ANCHORED
PROTEIN
(Staphylococcus
aureus) 		4 / 4 ILE E 298
THR E 317
LYS E 318
TYR E 310
 None
 1.30A 3elzC-5vmmE:
1.6		 3elzC-5vmmE:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_2
(DIHYDROFOLATE
REDUCTASE)		 5vmm IRON-REGULATED CELL
WALL-ANCHORED
PROTEIN
(Staphylococcus
aureus) 		4 / 4 PHE H 198
LYS H 125
ILE H 236
THR H 240
 None
 1.48A 3ia4B-5vmmH:
undetectable		 3ia4B-5vmmH:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 5vmm IRON-REGULATED CELL
WALL-ANCHORED
PROTEIN
(Staphylococcus
aureus) 		4 / 5 THR E 348
ILE E 371
GLU E 385
PHE E 418
 None
 1.37A 4ac9C-5vmmE:
undetectable		 4ac9C-5vmmE:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5vmm IRON-REGULATED CELL
WALL-ANCHORED
PROTEIN
(Staphylococcus
aureus) 		4 / 5 THR E 348
ILE E 371
GLU E 385
PHE E 418
 None
 1.33A 4acaC-5vmmE:
undetectable		 4acaC-5vmmE:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5vmm IRON-REGULATED CELL
WALL-ANCHORED
PROTEIN
(Staphylococcus
aureus) 		4 / 5 THR E 348
ILE E 371
GLU E 385
PHE E 418
 None
 1.40A 4acbC-5vmmE:
undetectable		 4acbC-5vmmE:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 5vmm IRON-REGULATED CELL
WALL-ANCHORED
PROTEIN
(Staphylococcus
aureus) 		5 / 12 LEU H 189
LEU H 187
PHE H 153
HIS H 166
SER H 238
 None
 1.37A 4aqlA-5vmmH:
undetectable		 4aqlA-5vmmH:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5vmm IRON-REGULATED CELL
WALL-ANCHORED
PROTEIN
(Staphylococcus
aureus) 		5 / 12 MET H 254
VAL H 234
VAL H 200
THR H 179
PHE H 178
 None
 1.26A 5igiA-5vmmH:
undetectable		 5igiA-5vmmH:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 5vmm IRON-REGULATED CELL
WALL-ANCHORED
PROTEIN
(Staphylococcus
aureus) 		6 / 12 VAL E 200
PHE E 198
ILE E 209
ILE E 223
LEU E 189
THR E 252
 None
 1.30A 5uvmB-5vmmE:
undetectable		 5uvmB-5vmmE:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 5vmm IRON-REGULATED CELL
WALL-ANCHORED
PROTEIN
(Staphylococcus
aureus) 		6 / 12 VAL H 200
PHE H 198
ILE H 209
ILE H 223
LEU H 189
THR H 252
 None
 1.36A 5uvmB-5vmmH:
undetectable		 5uvmB-5vmmH:
20.00