SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vms'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 5vms POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY
KQT MEMBER 1
(Xenopus
laevis) 		3 / 3 VAL A 177
VAL A 175
TRP A 178
 None
 0.97A 1bdwA-5vmsA:
undetectable
1bdwB-5vmsA:
undetectable		 1bdwA-5vmsA:
5.58
1bdwB-5vmsA:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 5vms POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY
KQT MEMBER 1
(Xenopus
laevis) 		4 / 8 VAL A 123
LEU A 153
SER A 199
VAL A 195
 None
 1.07A 1jtvA-5vmsA:
undetectable		 1jtvA-5vmsA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5vms POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY
KQT MEMBER 1
(Xenopus
laevis) 		4 / 4 ALA A 501
VAL A 505
ALA A 502
HIS A 499
 None
 0.96A 1q23A-5vmsA:
undetectable		 1q23A-5vmsA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5vms POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY
KQT MEMBER 1
(Xenopus
laevis) 		4 / 4 ALA A 501
VAL A 505
ALA A 502
HIS A 499
 None
 0.94A 1q23F-5vmsA:
undetectable		 1q23F-5vmsA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5vms POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY
KQT MEMBER 1
(Xenopus
laevis) 		4 / 4 ALA A 501
VAL A 505
ALA A 502
HIS A 499
 None
 0.97A 1q23K-5vmsA:
undetectable		 1q23K-5vmsA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5vms POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY
KQT MEMBER 1
(Xenopus
laevis) 		3 / 3 VAL A 505
ALA A 502
HIS A 499
 None
 0.80A 1q23L-5vmsA:
undetectable		 1q23L-5vmsA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5vms POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY
KQT MEMBER 1
(Xenopus
laevis) 		3 / 3 ARG A 182
VAL A 177
TRP A 178
 None
 1.20A 1qw6A-5vmsA:
undetectable		 1qw6A-5vmsA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5vms POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY
KQT MEMBER 1
(Xenopus
laevis) 		3 / 3 ARG A 182
VAL A 177
TRP A 178
 None
 1.25A 1vagA-5vmsA:
undetectable		 1vagA-5vmsA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 5vms POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY
KQT MEMBER 1
(Xenopus
laevis) 		4 / 6 MET A 149
VAL A 152
LEU A 153
PHE A 157
 None
 1.00A 1x8vA-5vmsA:
2.5		 1x8vA-5vmsA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5vms POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY
KQT MEMBER 1
(Xenopus
laevis) 		3 / 3 ARG A 182
VAL A 177
TRP A 178
 None
 1.27A 1zviA-5vmsA:
2.2		 1zviA-5vmsA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5vms POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY
KQT MEMBER 1
(Xenopus
laevis) 		4 / 7 ALA A 514
TYR A 511
ARG A 507
ALA A 368
 None
 1.10A 3twpC-5vmsA:
undetectable		 3twpC-5vmsA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 5vms POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY
KQT MEMBER 1
(Xenopus
laevis) 		4 / 5 ILE A 318
LEU A 261
GLY A 262
PHE A 265
 None
 0.81A 5kmdC-5vmsA:
7.1
5kmdD-5vmsA:
4.8		 5kmdC-5vmsA:
20.92
5kmdD-5vmsA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5vms POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY
KQT MEMBER 1
(Xenopus
laevis) 		4 / 6 ARG A 522
LEU A 364
ALA A 368
GLN A 357
 None
 0.98A 6b89B-5vmsA:
undetectable		 6b89B-5vmsA:
10.74