SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vn2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5vn2 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
melitensis) 		5 / 9 THR A 117
GLY A 116
GLY A 164
PHE A 168
LEU A 165
 None
 1.23A 1l4nA-5vn2A:
3.1		 1l4nA-5vn2A:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5vn2 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
melitensis) 		5 / 11 SER A 139
CYH A  83
LEU A  84
THR A  11
ILE A  34
 None
 1.22A 1pkvA-5vn2A:
undetectable
1pkvB-5vn2A:
undetectable		 1pkvA-5vn2A:
16.23
1pkvB-5vn2A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5vn2 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
melitensis) 		5 / 11 SER A 139
CYH A  83
LEU A  84
THR A  11
ILE A  34
 None
 1.21A 1pkvA-5vn2A:
undetectable
1pkvB-5vn2A:
undetectable		 1pkvA-5vn2A:
16.23
1pkvB-5vn2A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5vn2 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
melitensis) 		5 / 12 GLY A  12
ASP A  36
ARG A  37
ASP A  60
ASN A  87
 NAD  A 301 (-3.3A)
NAD  A 301 (-2.8A)
NAD  A 301 (-4.3A)
NAD  A 301 (-3.7A)
NAD  A 301 (-3.3A)
 0.88A 2bm9B-5vn2A:
5.6		 2bm9B-5vn2A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5vn2 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
melitensis) 		5 / 12 GLY A  12
ASP A  36
ASP A  60
ASN A  87
ALA A  88
 NAD  A 301 (-3.3A)
NAD  A 301 (-2.8A)
NAD  A 301 (-3.7A)
NAD  A 301 (-3.3A)
NAD  A 301 (-3.6A)
 0.96A 2bm9E-5vn2A:
5.6		 2bm9E-5vn2A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5vn2 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
melitensis) 		4 / 5 PHE A 120
THR A  70
LEU A  75
ALA A 123
 None
 1.31A 2e1qD-5vn2A:
undetectable		 2e1qD-5vn2A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5vn2 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
melitensis) 		5 / 12 LEU A  61
GLY A 116
ALA A 123
THR A 121
LEU A 172
 NAD  A 301 (-4.3A)
None
None
None
None
 1.26A 3dh0A-5vn2A:
6.7		 3dh0A-5vn2A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5vn2 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
melitensis) 		4 / 6 TYR A 158
ILE A 109
SER A 148
SER A 145
 ACT  A 302 ( 4.2A)
None
None
ACT  A 302 ( 2.6A)
 1.27A 3pmzD-5vn2A:
undetectable		 3pmzD-5vn2A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5vn2 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
melitensis) 		4 / 6 TYR A 158
ILE A 109
SER A 148
SER A 147
 ACT  A 302 ( 4.2A)
None
None
ACT  A 302 (-3.3A)
 1.28A 3pmzD-5vn2A:
undetectable		 3pmzD-5vn2A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 5vn2 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
melitensis) 		4 / 5 SER A 147
ILE A 143
TYR A 158
GLY A 189
 ACT  A 302 (-3.3A)
NAD  A 301 (-4.7A)
ACT  A 302 ( 4.2A)
NAD  A 301 ( 4.8A)
 0.91A 3uboB-5vn2A:
6.5		 3uboB-5vn2A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5vn2 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
melitensis) 		5 / 9 THR A 117
GLY A 116
GLY A 164
PHE A 168
LEU A 165
 None
 1.22A 4kqiA-5vn2A:
2.4		 4kqiA-5vn2A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 5vn2 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
melitensis) 		5 / 12 TRP A 217
THR A 193
THR A 196
ALA A 197
ALA A 200
 None
NAD  A 301 (-2.7A)
NAD  A 301 (-3.9A)
None
None
 1.42A 4u15A-5vn2A:
undetectable		 4u15A-5vn2A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 5vn2 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE
(Brucella
melitensis) 		4 / 5 SER A 147
SER A 148
SER A 145
SER A 161
 ACT  A 302 (-3.3A)
None
ACT  A 302 ( 2.6A)
None
 1.11A 5hswA-5vn2A:
undetectable		 5hswA-5vn2A:
19.35