SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vn3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5vn3 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 0.95A 1dhiA-5vn3G:
undetectable		 1dhiA-5vn3G:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5vn3 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 0.96A 1dhjA-5vn3G:
undetectable		 1dhjA-5vn3G:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5vn3 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 0.98A 1drbA-5vn3G:
undetectable		 1drbA-5vn3G:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 5vn3 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 THR G 373
ILE G 424
ILE G 423
GLU G 381
ALA G 329
 None
 1.29A 1jtxA-5vn3G:
undetectable		 1jtxA-5vn3G:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 5vn3 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		4 / 6 PRO G 354
PHE G 353
GLN G 352
VAL G 346
 NAG  G 623 (-4.3A)
None
None
None
 1.47A 1l2iB-5vn3G:
undetectable		 1l2iB-5vn3G:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5vn3 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 0.95A 1ra3A-5vn3G:
undetectable		 1ra3A-5vn3G:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 5vn3 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 0.97A 1rb3B-5vn3G:
undetectable		 1rb3B-5vn3G:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 5vn3 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 1.03A 1rd7B-5vn3G:
undetectable		 1rd7B-5vn3G:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5vn3 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		4 / 8 SER G 236
ASN G 234
PHE G 233
ASN G  94
 NAG  G 602 ( 3.8A)
NAG  G 602 (-1.9A)
None
None
 1.34A 1rs6A-5vn3G:
undetectable		 1rs6A-5vn3G:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5vn3 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 1.00A 1rx7A-5vn3G:
undetectable		 1rx7A-5vn3G:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_B_CHDB500_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5vn3 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		4 / 4 LEU G  86
VAL G  85
ILE G  84
TRP G  45
 None
 1.44A 1s9qB-5vn3G:
undetectable		 1s9qB-5vn3G:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 5vn3 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 0.97A 2d0kB-5vn3G:
undetectable		 2d0kB-5vn3G:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5vn3 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 0.98A 2drcA-5vn3G:
undetectable		 2drcA-5vn3G:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 5vn3 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		4 / 6 TYR G 217
MET G 100
TYR G 486
HIS G 249
 None
 1.39A 2pncB-5vn3G:
undetectable		 2pncB-5vn3G:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5vn3 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 0.97A 3drcA-5vn3G:
undetectable		 3drcA-5vn3G:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5vn3 ENVELOPE
GLYCOPROTEIN GP160
ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1;
Human
immunodeficiency
virus
1) 		5 / 12 ALA A 517
THR G 244
ILE A 519
PHE A 522
GLU G  91
 None
 1.12A 3nvkI-5vn3A:
undetectable		 3nvkI-5vn3A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 5vn3 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 LEU G 288
PHE G 361
VAL G 286
TRP G 338
PHE G 391
 None
 1.29A 4c9wA-5vn3G:
undetectable		 4c9wA-5vn3G:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vn3 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 9 THR A 627
ALA A 533
ALA A 536
GLY A 527
ALA A 525
 None
 1.11A 4qvnK-5vn3A:
undetectable
4qvnL-5vn3A:
undetectable		 4qvnK-5vn3A:
20.10
4qvnL-5vn3A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vn3 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 9 THR A 627
ALA A 533
ALA A 536
GLY A 527
ALA A 525
 None
 1.11A 4qvnY-5vn3A:
undetectable
4qvnZ-5vn3A:
undetectable		 4qvnY-5vn3A:
20.10
4qvnZ-5vn3A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vn3 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 9 THR A 627
ALA A 533
ALA A 536
GLY A 527
ALA A 525
 None
 1.11A 4qvqK-5vn3A:
undetectable
4qvqL-5vn3A:
undetectable		 4qvqK-5vn3A:
20.10
4qvqL-5vn3A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5vn3 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 9 THR A 627
ALA A 533
ALA A 536
GLY A 527
ALA A 525
 None
 1.11A 4qvqY-5vn3A:
undetectable
4qvqZ-5vn3A:
undetectable		 4qvqY-5vn3A:
20.10
4qvqZ-5vn3A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5vn3 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 PHE A 522
GLY A 516
ALA A 525
ILE A 519
TYR A 586
 None
 1.29A 4rtpA-5vn3A:
undetectable		 4rtpA-5vn3A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 5vn3 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 GLN G 352
ILE G 345
LEU G 453
VAL G 286
ILE G 270
 None
 0.91A 4uw0A-5vn3G:
undetectable		 4uw0A-5vn3G:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5vn3 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		4 / 4 PHE G 468
ILE G 358
GLN G 352
ARG G 456
 None
 1.12A 5jm4B-5vn3G:
undetectable		 5jm4B-5vn3G:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 5vn3 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		4 / 8 ILE A 622
ALA G 497
ILE A 635
GLU A 634
 None
 0.76A 5mvmA-5vn3A:
undetectable
5mvmB-5vn3A:
undetectable		 5mvmA-5vn3A:
18.71
5mvmB-5vn3A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5vn3 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 0.99A 5ujxA-5vn3G:
undetectable		 5ujxA-5vn3G:
14.62