SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vn4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 5vn4 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 7 TYR A  10
PHE A 200
GLY A 177
GLY A 174
 None
 0.79A 11gsB-5vn4A:
undetectable		 11gsB-5vn4A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5vn4 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 VAL A 159
GLY A 158
MET A 155
LEU A 144
GLU A 171
 None
 1.45A 1a27A-5vn4A:
undetectable		 1a27A-5vn4A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5vn4 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 THR A 202
VAL A 201
VAL A  45
LEU A  85
ILE A  48
 None
 1.41A 3elzA-5vn4A:
undetectable		 3elzA-5vn4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5vn4 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 11 THR A 202
VAL A 201
VAL A  45
LEU A  85
ILE A  48
 None
 1.31A 3elzB-5vn4A:
undetectable		 3elzB-5vn4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 5vn4 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ARG A 102
GLY A  83
GLY A  78
LEU A  86
LEU A 144
 None
 1.15A 3kkzA-5vn4A:
2.2		 3kkzA-5vn4A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 5vn4 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 8 TYR A  10
PHE A 200
GLY A 177
GLY A 174
 None
 0.81A 3n9jB-5vn4A:
undetectable		 3n9jB-5vn4A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 5vn4 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ILE A  76
GLU A 171
PHE A  62
VAL A 201
VAL A 143
 None
 1.47A 3qwuA-5vn4A:
undetectable		 3qwuA-5vn4A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5vn4 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ASP A 146
VAL A 172
VAL A 131
ILE A 112
LEU A 169
 HSX  A 302 (-2.8A)
None
None
None
None
 1.27A 4a84A-5vn4A:
undetectable		 4a84A-5vn4A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 5vn4 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 7 ASN A   9
VAL A 201
GLU A 171
ARG A  65
 None
 1.03A 4mv7A-5vn4A:
undetectable		 4mv7A-5vn4A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 5vn4 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(Trypanosoma
brucei) 		3 / 3 VAL A 170
THR A 168
ARG A 141
 None
 0.78A 5b2sB-5vn4A:
undetectable		 5b2sB-5vn4A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5vn4 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 6 GLU A 127
TYR A 117
GLY A 153
GLY A 152
 None
None
HSX  A 302 (-3.9A)
HSX  A 302 (-3.5A)
 0.94A 5x7pB-5vn4A:
undetectable		 5x7pB-5vn4A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 5vn4 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(Trypanosoma
brucei) 		4 / 5 GLU A 171
VAL A 201
LEU A   3
HIS A   0
 None
 1.28A 6dyoA-5vn4A:
undetectable		 6dyoA-5vn4A:
14.11