SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vni'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
3 / 3 ALA A  31
VAL A  38
TRP A  21
None
0.97A 1c4dA-5vniA:
undetectable
1c4dB-5vniA:
undetectable
1c4dA-5vniA:
2.27
1c4dB-5vniA:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
5 / 12 LEU A 718
THR A 708
GLU A 709
GLY A 711
HIS A 710
None
1.35A 1d4fC-5vniA:
undetectable
1d4fC-5vniA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
4 / 5 GLU B 734
TYR B 714
TYR B 716
PHE B1048
None
1.44A 1dfoB-5vniB:
undetectable
1dfoB-5vniB:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
4 / 5 GLU B 734
TYR B 714
TYR B 716
PHE B1048
None
1.44A 1dfoA-5vniB:
undetectable
1dfoA-5vniB:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
4 / 5 GLU B 734
TYR B 714
TYR B 716
PHE B1048
None
1.44A 1dfoD-5vniB:
undetectable
1dfoD-5vniB:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
4 / 5 GLU B 734
TYR B 714
TYR B 716
PHE B1048
None
1.44A 1dfoC-5vniB:
undetectable
1dfoC-5vniB:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
3 / 3 GLU A 520
ALA A 522
SER A  20
None
0.58A 1errB-5vniA:
undetectable
1errB-5vniA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
5 / 12 VAL B 996
LEU B1009
GLY B 997
SER B1016
MET B1021
None
1.44A 1fdsA-5vniB:
2.9
1fdsA-5vniB:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
5 / 12 TYR B 556
LEU B 529
LEU B 530
HIS B 554
LEU B 522
None
1.39A 1fmlA-5vniB:
undetectable
1fmlA-5vniB:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
5 / 11 GLY A 283
GLY A 401
GLN A 486
GLY A 368
GLY A 369
None
0.93A 1mxgA-5vniA:
undetectable
1mxgA-5vniA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
5 / 12 ILE A 438
LEU A 550
ILE A 619
LEU A 590
ILE A 531
None
1.06A 1oipA-5vniA:
2.2
1oipA-5vniA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
4 / 7 PHE A 461
VAL A  17
GLY A  16
ILE A 479
None
0.79A 1p2yA-5vniA:
undetectable
1p2yA-5vniA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
5 / 12 LEU A 275
LEU A 274
GLY A 273
THR A 367
ILE A 345
None
1.36A 1p93A-5vniA:
undetectable
1p93A-5vniA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
5 / 11 PHE A 382
PHE A 289
LEU A 247
VAL A 135
THR A 137
None
1.35A 1q23F-5vniA:
undetectable
1q23F-5vniA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
5 / 12 VAL B 892
LEU B 400
ALA B 403
LEU B 405
ALA B 838
None
1.19A 1sa1C-5vniB:
4.0
1sa1D-5vniB:
4.3
1sa1C-5vniB:
20.53
1sa1D-5vniB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
3 / 3 ASP A 547
PHE A 752
ARG A 585
None
0.90A 2a3aA-5vniA:
undetectable
2a3aA-5vniA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
4 / 5 LEU B 808
PRO B 493
ALA B 492
ILE B 818
None
1.04A 2aofB-5vniB:
undetectable
2aofB-5vniB:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A
VESICLE-TRAFFICKING
PROTEIN SEC22B

(Homo
sapiens;
Mus
musculus)
3 / 3 SER B 561
GLU B 582
ASP C 128
None
0.73A 2avdB-5vniB:
undetectable
2avdB-5vniB:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A
PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens;
Homo
sapiens)
3 / 3 LYS A 193
ASP B 550
ASP B 572
None
0.95A 2br4D-5vniA:
undetectable
2br4D-5vniA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
4 / 8 VAL B 903
VAL B 871
LEU B 907
HIS B1086
None
0.95A 2ddwA-5vniB:
3.3
2ddwA-5vniB:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
5 / 9 GLY A 418
GLU A 437
ASN A 436
ALA A  39
VAL A  38
None
1.34A 2drdA-5vniA:
3.0
2drdA-5vniA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
5 / 12 GLU B1058
TRP B 995
LEU B1066
MET B1069
ARG B 980
None
1.35A 2jj8C-5vniB:
undetectable
2jj8C-5vniB:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
5 / 12 LYS A 447
CYH A 423
LEU A 457
ILE A 459
GLY A  16
None
1.20A 2lbdA-5vniA:
undetectable
2lbdA-5vniA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
5 / 12 LEU A 274
LEU A 268
ALA A 267
LEU A 166
PHE A 189
None
1.28A 2oaxB-5vniA:
undetectable
2oaxB-5vniA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
5 / 12 ASN B 778
MET B 627
LEU B 620
LEU B 507
PHE B 745
None
1.24A 2oaxB-5vniB:
undetectable
2oaxB-5vniB:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
5 / 12 LEU A 274
LEU A 268
ALA A 267
LEU A 166
PHE A 189
None
1.30A 2oaxD-5vniA:
undetectable
2oaxD-5vniA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
4 / 5 LEU B 847
MET B 939
CYH B 388
THR B 391
None
1.42A 2oaxD-5vniB:
undetectable
2oaxD-5vniB:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
5 / 12 LEU A 274
LEU A 268
ALA A 267
LEU A 166
PHE A 189
None
1.25A 2oaxE-5vniA:
undetectable
2oaxE-5vniA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
5 / 12 ASN B 778
MET B 627
LEU B 620
LEU B 507
PHE B 745
None
1.17A 2oaxF-5vniB:
undetectable
2oaxF-5vniB:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
4 / 4 GLU B 734
TYR B 714
TYR B 716
PHE B1048
None
1.49A 2vmyB-5vniB:
undetectable
2vmyB-5vniB:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
4 / 8 GLY A 265
GLY A 297
GLN A 296
THR A 295
None
0.75A 2wd9B-5vniA:
undetectable
2wd9B-5vniA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
5 / 12 PHE B 510
PHE B 549
VAL B 525
ALA B 619
ALA B 623
None
1.21A 2x2nC-5vniB:
undetectable
2x2nC-5vniB:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
5 / 12 PHE B 803
VAL B 801
ALA B 842
LEU B 400
MET B 789
None
1.21A 2x2nC-5vniB:
undetectable
2x2nC-5vniB:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
5 / 12 PHE B 899
PRO B 900
VAL B 903
ALA B 403
ALA B 877
None
1.27A 2x2nC-5vniB:
undetectable
2x2nC-5vniB:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
4 / 6 LEU B 399
GLN B 397
LEU B 831
PHE B 835
None
0.99A 3ag1C-5vniB:
undetectable
3ag1J-5vniB:
undetectable
3ag1C-5vniB:
15.19
3ag1J-5vniB:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_1
(PHOSPHOLIPASE A2)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
5 / 10 VAL A 301
GLU A 359
GLY A 299
LYS A 322
ARG A 311
None
1.41A 3bjwD-5vniA:
undetectable
3bjwD-5vniA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
4 / 7 PHE B 925
PHE B1048
SER B 990
TYR B 937
None
1.08A 3hggA-5vniB:
undetectable
3hggA-5vniB:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A
VESICLE-TRAFFICKING
PROTEIN SEC22B

(Homo
sapiens;
Mus
musculus)
4 / 5 THR B 424
SER C 107
SER C 111
ARG C 108
None
1.25A 3hlwB-5vniB:
undetectable
3hlwB-5vniB:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA303_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
4 / 4 GLN B 929
GLN B 933
GLY B 784
HIS B 412
None
1.20A 3huoA-5vniB:
undetectable
3huoA-5vniB:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA304_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
4 / 4 GLN B 933
PRO B 934
VAL B 936
GLU B 384
None
1.34A 3huoA-5vniB:
undetectable
3huoA-5vniB:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
4 / 8 TYR A  98
GLY A 100
SER A 102
ILE A 101
None
0.83A 3ihzB-5vniA:
undetectable
3ihzB-5vniA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
5 / 12 GLY A 374
ASP A 598
VAL A 301
GLY A 292
PHE A 377
None
1.21A 3k13A-5vniA:
undetectable
3k13A-5vniA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
5 / 10 TRP A 252
THR A 137
VAL A 135
ILE A 167
SER A 186
None
1.17A 3kpbD-5vniA:
undetectable
3kpbD-5vniA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
5 / 12 ASN B 778
MET B 627
LEU B 507
ILE B 743
PHE B 745
None
1.23A 3mnoA-5vniB:
undetectable
3mnoA-5vniB:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
5 / 12 GLY B 764
VAL B 779
LEU B 807
ILE B 759
PHE B 762
None
1.37A 3mnoA-5vniB:
undetectable
3mnoA-5vniB:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
5 / 11 THR A 440
ALA A 458
ILE A 420
THR A 497
PRO A  44
None
1.42A 3qelA-5vniA:
undetectable
3qelB-5vniA:
undetectable
3qelA-5vniA:
19.92
3qelB-5vniA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
5 / 11 VAL B 991
ALA B 988
GLY B 989
TYR B 937
ALA B 926
None
1.32A 3qxyB-5vniB:
0.8
3qxyQ-5vniB:
undetectable
3qxyB-5vniB:
20.62
3qxyQ-5vniB:
2.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA803_1
(CATALASE-PEROXIDASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
4 / 4 ASP A 237
THR A 241
VAL A 164
SER A 156
None
1.47A 3wxoA-5vniA:
undetectable
3wxoA-5vniA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
3 / 3 LYS A 758
LYS A 757
PRO A 565
None
1.23A 4dv1L-5vniA:
undetectable
4dv1L-5vniA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
4 / 7 VAL B 350
VAL B 892
LEU B 896
VAL B 871
None
1.14A 4e1gB-5vniB:
undetectable
4e1gB-5vniB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
3 / 3 ARG B 750
TYR B 456
ASN B 459
None
0.71A 4ffwB-5vniB:
3.7
4ffwB-5vniB:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
3 / 3 PRO A 422
ASN A 365
HIS A 605
None
1.03A 4ma3H-5vniA:
1.1
4ma3L-5vniA:
1.6
4ma3H-5vniA:
15.12
4ma3L-5vniA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
4 / 7 ARG A 262
ILE A 347
LEU A 357
ASP A 598
None
1.08A 4mmcA-5vniA:
undetectable
4mmcA-5vniA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
5 / 12 ALA B 786
GLY B 784
LEU B 410
LEU B 938
VAL B 930
None
0.94A 4o33A-5vniB:
3.0
4o33A-5vniB:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
5 / 11 ILE B1036
LEU B1009
LEU B1052
ILE B1039
THR B1029
None
1.01A 4p66A-5vniB:
undetectable
4p66A-5vniB:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
3 / 3 MET A 287
MET A 360
TYR A 370
None
1.21A 4p6xI-5vniA:
undetectable
4p6xI-5vniA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
3 / 3 LYS B 674
ARG B 769
VAL B 768
None
0.94A 4x3uA-5vniB:
undetectable
4x3uB-5vniB:
undetectable
4x3uA-5vniB:
6.75
4x3uB-5vniB:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
5 / 12 ILE B1036
LEU B1009
LEU B1052
ILE B1039
THR B1029
None
1.04A 4x5gB-5vniB:
undetectable
4x5gB-5vniB:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
5 / 12 ILE B1036
LEU B1009
LEU B1052
ILE B1039
THR B1029
None
0.86A 4x5iA-5vniB:
undetectable
4x5iA-5vniB:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
4 / 6 GLU A 694
ILE A 647
HIS A 660
PRO A 703
None
0.91A 4xi3C-5vniA:
undetectable
4xi3C-5vniA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
5 / 12 PHE A 580
MET A 581
LEU A 616
LEU A 612
LEU A  41
None
1.31A 4xumA-5vniA:
undetectable
4xumA-5vniA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_C_PACC601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
5 / 12 PHE A 570
PHE A 574
VAL A  35
TRP A  21
VAL A  36
None
1.36A 4yfbC-5vniA:
undetectable
4yfbC-5vniA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_F_PACF601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
5 / 12 PHE A 570
PHE A 574
VAL A  35
TRP A  21
VAL A  36
None
1.36A 4yfbF-5vniA:
undetectable
4yfbF-5vniA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
5 / 12 PHE A 570
PHE A 574
VAL A  35
TRP A  21
VAL A  36
None
1.36A 4yfbI-5vniA:
undetectable
4yfbI-5vniA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_L_PACL601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
5 / 12 PHE A 570
PHE A 574
VAL A  35
TRP A  21
VAL A  36
None
1.34A 4yfbL-5vniA:
undetectable
4yfbL-5vniA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
4 / 5 THR A 652
THR A 708
HIS A 710
LEU A 719
None
1.21A 5axaA-5vniA:
undetectable
5axaA-5vniA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
4 / 5 THR A 652
THR A 708
HIS A 710
LEU A 719
None
1.23A 5axaC-5vniA:
undetectable
5axaC-5vniA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
5 / 12 GLY A 165
THR A 168
ILE A 130
LYS A 225
LEU A 230
None
1.09A 5bw4A-5vniA:
undetectable
5bw4A-5vniA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)
5vni VESICLE-TRAFFICKING
PROTEIN SEC22B

(Mus
musculus)
3 / 3 ASP C  12
GLU C  46
SER C 111
None
0.76A 5bw4B-5vniC:
undetectable
5bw4B-5vniC:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
5 / 12 GLY B 645
ASP B 511
SER B 513
THR B 639
TYR B 673
None
1.36A 5d0yA-5vniB:
undetectable
5d0yA-5vniB:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
5 / 12 GLY B 711
TYR B 673
ALA B 783
ALA B 710
TYR B 785
None
1.18A 5kvaA-5vniB:
undetectable
5kvaA-5vniB:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
5 / 12 GLY B 711
TYR B 673
ALA B 783
ALA B 710
TYR B 785
None
1.19A 5kvaB-5vniB:
undetectable
5kvaB-5vniB:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
4 / 6 GLU B 489
ARG B 819
LEU B 807
ARG B 816
None
0.98A 5l6eA-5vniB:
1.5
5l6eB-5vniB:
1.7
5l6eA-5vniB:
12.95
5l6eB-5vniB:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
5 / 10 PRO A  44
LEU A  41
ILE A 524
ALA A 527
PHE A 607
None
1.39A 5m0oA-5vniA:
undetectable
5m0oA-5vniA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
4 / 4 ASN B 778
SER B 706
ALA B 686
VAL B 685
None
1.28A 5nm5A-5vniB:
5.3
5nm5A-5vniB:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
3 / 3 HIS B 721
HIS B 720
HIS B 723
None
1.02A 5oexA-5vniB:
undetectable
5oexA-5vniB:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
4 / 8 TRP B 450
THR B 436
TYR B 437
THR B 822
None
ZN  B1101 ( 4.6A)
None
None
1.27A 5tzoB-5vniB:
undetectable
5tzoB-5vniB:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A
VESICLE-TRAFFICKING
PROTEIN SEC22B

(Homo
sapiens;
Mus
musculus)
4 / 6 THR B 540
ASN B 539
ILE C 113
GLU B 815
None
1.23A 5uigA-5vniB:
undetectable
5uigA-5vniB:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
4 / 5 THR A 652
THR A 708
HIS A 710
LEU A 719
None
1.20A 5utuH-5vniA:
undetectable
5utuH-5vniA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
5 / 12 ALA B 516
GLY B 520
ASP B 511
LEU B 702
LEU B 689
None
1.01A 5wwsA-5vniB:
undetectable
5wwsA-5vniB:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
5 / 12 LEU A 426
GLY A 403
GLN A 486
LEU A  45
ILE A 448
None
1.10A 5y2tA-5vniA:
undetectable
5y2tA-5vniA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
5 / 10 LEU B1005
LEU B 952
PHE B1038
LEU B 985
LEU B1024
None
1.25A 5y7pD-5vniB:
undetectable
5y7pD-5vniB:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_1
(CARNOSINE
N-METHYLTRANSFERASE)
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens)
4 / 5 GLN B 727
TYR B1053
GLU B 734
ASP B 782
None
1.50A 5yf0A-5vniB:
0.8
5yf0A-5vniB:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo
sapiens)
4 / 7 PRO A  72
LEU A  73
PHE A  94
LEU A 110
None
1.12A 6aycA-5vniA:
undetectable
6aycA-5vniA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A
PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo
sapiens;
Homo
sapiens)
5 / 12 PHE A 189
SER A 269
LEU A 200
ARG A 190
ASP B 575
None
1.01A 6bxmA-5vniA:
undetectable
6bxmA-5vniA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)
5vni PROTEIN TRANSPORT
PROTEIN SEC23A
VESICLE-TRAFFICKING
PROTEIN SEC22B

(Homo
sapiens;
Mus
musculus)
4 / 5 GLY A 257
LEU A 306
SER C 129
GLN A 256
None
1.10A 6ji6A-5vniA:
undetectable
6ji6A-5vniA:
13.77