SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vnx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5vnx 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Burkholderia
multivorans) 		4 / 8 HIS A 137
SER A 183
HIS A 211
ARG A 367
 9EV  A 242 ( 3.5A)
9EV  A 242 ( 2.9A)
9EV  A 242 ( 3.5A)
None
 1.11A 1eqbA-5vnxA:
28.3
1eqbB-5vnxA:
28.6		 1eqbA-5vnxA:
25.17
1eqbB-5vnxA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5vnx 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Burkholderia
multivorans) 		4 / 8 HIS A 137
SER A 183
HIS A 211
ARG A 367
 9EV  A 242 ( 3.5A)
9EV  A 242 ( 2.9A)
9EV  A 242 ( 3.5A)
None
 1.09A 1eqbA-5vnxA:
28.3
1eqbB-5vnxA:
28.6		 1eqbA-5vnxA:
25.17
1eqbB-5vnxA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5vnx 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Burkholderia
multivorans) 		4 / 8 HIS A 137
SER A 183
HIS A 211
ARG A 367
 9EV  A 242 ( 3.5A)
9EV  A 242 ( 2.9A)
9EV  A 242 ( 3.5A)
None
 1.10A 1eqbC-5vnxA:
28.8
1eqbD-5vnxA:
28.4		 1eqbC-5vnxA:
25.17
1eqbD-5vnxA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5vnx 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Burkholderia
multivorans) 		4 / 8 HIS A 137
SER A 183
HIS A 211
ARG A 367
 9EV  A 242 ( 3.5A)
9EV  A 242 ( 2.9A)
9EV  A 242 ( 3.5A)
None
 1.09A 1eqbC-5vnxA:
28.8
1eqbD-5vnxA:
28.4		 1eqbC-5vnxA:
25.17
1eqbD-5vnxA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 5vnx 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Burkholderia
multivorans) 		5 / 11 ALA A 119
ALA A 115
LEU A 286
TYR A 236
LEU A  93
 None
None
EDO  A 604 (-4.3A)
None
None
 1.13A 1rlbF-5vnxA:
undetectable		 1rlbF-5vnxA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 5vnx 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Burkholderia
multivorans) 		4 / 8 ALA A 210
VAL A 181
THR A 180
THR A 178
 9EV  A 242 ( 3.4A)
None
None
None
 1.17A 2kotB-5vnxA:
undetectable		 2kotB-5vnxA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5vnx 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Burkholderia
multivorans) 		5 / 12 PHE A 250
ALA A 227
ALA A 189
THR A 178
VAL A 207
 None
 1.25A 2ve3B-5vnxA:
undetectable		 2ve3B-5vnxA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5vnx 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Burkholderia
multivorans) 		4 / 8 HIS A 137
SER A 183
HIS A 211
ARG A 367
 9EV  A 242 ( 3.5A)
9EV  A 242 ( 2.9A)
9EV  A 242 ( 3.5A)
None
 1.21A 2vmyA-5vnxA:
29.5
2vmyB-5vnxA:
29.4		 2vmyA-5vnxA:
26.02
2vmyB-5vnxA:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5vnx 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Burkholderia
multivorans) 		4 / 8 LEU A 261
LEU A 107
ALA A 115
HIS A  77
 None
 1.06A 2wekA-5vnxA:
4.8		 2wekA-5vnxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 5vnx 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Burkholderia
multivorans) 		4 / 6 ALA A 243
HIS A 211
VAL A 326
ASN A  47
 9EV  A 242 ( 3.7A)
9EV  A 242 ( 3.5A)
None
9EV  A 242 ( 4.0A)
 1.14A 3nneG-5vnxA:
undetectable		 3nneG-5vnxA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 5vnx 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Burkholderia
multivorans) 		5 / 10 ILE A 258
ASN A 116
ALA A 119
LEU A 123
VAL A 206
 None
9EV  A 242 ( 4.5A)
None
None
None
 1.24A 3o02A-5vnxA:
undetectable
3o02B-5vnxA:
undetectable		 3o02A-5vnxA:
23.63
3o02B-5vnxA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5vnx 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Burkholderia
multivorans) 		4 / 4 LEU A 216
GLY A 222
GLY A 212
THR A 180
 None
 0.89A 3si7A-5vnxA:
undetectable		 3si7A-5vnxA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 5vnx 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Burkholderia
multivorans) 		4 / 8 ASN A 136
ASP A 179
ASP A 133
VAL A 153
 None
9EV  A 242 ( 3.7A)
None
None
 1.01A 4f8hB-5vnxA:
undetectable
4f8hC-5vnxA:
undetectable		 4f8hB-5vnxA:
23.36
4f8hC-5vnxA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 5vnx 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Burkholderia
multivorans) 		4 / 8 ASN A 136
ASP A 179
ASP A 133
VAL A 153
 None
9EV  A 242 ( 3.7A)
None
None
 1.01A 4f8hD-5vnxA:
undetectable
4f8hE-5vnxA:
undetectable		 4f8hD-5vnxA:
23.36
4f8hE-5vnxA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 5vnx 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Burkholderia
multivorans) 		4 / 8 VAL A 153
ASN A 136
ASP A 179
ASP A 133
 None
None
9EV  A 242 ( 3.7A)
None
 1.00A 4f8hA-5vnxA:
undetectable
4f8hE-5vnxA:
undetectable		 4f8hA-5vnxA:
23.36
4f8hE-5vnxA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 5vnx 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Burkholderia
multivorans) 		5 / 12 SER A 285
LEU A 286
PHE A 213
ASP A 209
GLY A 217
 None
EDO  A 604 (-4.3A)
None
None
None
 1.28A 4j7xF-5vnxA:
undetectable		 4j7xF-5vnxA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 5vnx 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Burkholderia
multivorans) 		4 / 5 GLY A 186
ARG A 309
ASP A 185
MET A 184
 None
None
EDO  A 606 (-3.8A)
BEN  A 601 ( 4.5A)
 1.41A 5ubbA-5vnxA:
2.3		 5ubbA-5vnxA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 5vnx 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Burkholderia
multivorans) 		4 / 4 VAL A 326
GLY A 186
ASP A 185
ASP A 179
 None
None
EDO  A 606 (-3.8A)
9EV  A 242 ( 3.7A)
 1.26A 6cjkC-5vnxA:
undetectable		 6cjkC-5vnxA:
20.62