SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vnz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NNH_A_9CRA502_1 (CYTOCHROME P450 2C8)	5vnz	TNF RECEPTOR-ASSOCIATED FACTOR 6 (Danio rerio)	5 / 12	ILE A 99 SER A 98 ILE A 95 LEU A 113 VAL A 82	None	1.00A	2nnhA-5vnzA: undetectable	2nnhA-5vnzA: 12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HRQ_G_IPHG101_0 (INSULIN A-CHAIN INSULIN B-CHAIN)	5vnz	TNF RECEPTOR-ASSOCIATED FACTOR 6 (Danio rerio)	4 / 6	LEU A 65 CYH A 71 CYH A 74 LEU A 78	None ZN A 201 (-2.3A) ZN A 201 (-2.3A) None	1.35A	5hrqD-5vnzA: undetectable 5hrqG-5vnzA: undetectable 5hrqH-5vnzA: undetectable	5hrqD-5vnzA: undetectable 5hrqG-5vnzA: undetectable 5hrqH-5vnzA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5INZ_D_DVAD2_0 (THETA DEFENSIN-2, D-PEPTIDE THETA DEFENSIN-2, L-PEPTIDE)	5vnz	TNF RECEPTOR-ASSOCIATED FACTOR 6 (Danio rerio)	4 / 4	GLY A 56 CYH A 74 ARG A 79 GLY A 77	ZN A 201 ( 4.7A) ZN A 201 (-2.3A) None None	1.34A	5inzA-5vnzA: undetectable 5inzC-5vnzA: undetectable 5inzD-5vnzA: undetectable	5inzA-5vnzA: undetectable 5inzC-5vnzA: undetectable 5inzD-5vnzA: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2NNH_A_9CRA502_1","CYTOCHROME P450 2C8","5vnz","TNF RECEPTOR-ASSOCIATED FACTOR 6","Danio rerio",5,"ILE A  99;SER A  98;ILE A  95;LEU A 113;VAL A  82","None","1.00A","2nnhA-5vnzA:undetectable","2nnhA-5vnzA:12.64"],["5HRQ_G_IPHG101_0","INSULIN A-CHAIN;INSULIN B-CHAIN","5vnz","TNF RECEPTOR-ASSOCIATED FACTOR 6","Danio rerio",4,"LEU A  65;CYH A  71;CYH A  74;LEU A  78","None; ZN A 201 (-2.3A); ZN A 201 (-2.3A);None","1.35A","5hrqD-5vnzA:undetectable;5hrqG-5vnzA:undetectable;5hrqH-5vnzA:undetectable","5hrqD-5vnzA:undetectable;5hrqG-5vnzA:undetectable;5hrqH-5vnzA:undetectable"],["5INZ_D_DVAD2_0","THETA DEFENSIN-2, D-PEPTIDE;THETA DEFENSIN-2, L-PEPTIDE","5vnz","TNF RECEPTOR-ASSOCIATED FACTOR 6","Danio rerio",4,"GLY A  56;CYH A  74;ARG A  79;GLY A  77"," ZN A 201 ( 4.7A); ZN A 201 (-2.3A);None;None","1.34A","5inzA-5vnzA:undetectable;5inzC-5vnzA:undetectable;5inzD-5vnzA:undetectable","5inzA-5vnzA:undetectable;5inzC-5vnzA:undetectable;5inzD-5vnzA:undetectable"]]