SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5voc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
4 / 4 THR A 453
LEU A 450
LEU A 469
GLN A 375
None
1.18A 1fbmA-5vocA:
undetectable
1fbmA-5vocA:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)
5voc ENVELOPE
GLYCOPROTEIN UL131A

(Human
betaherpesvirus
5)
4 / 6 PRO E  45
GLN E  47
LYS E  51
VAL E  53
None
None
NAG  E 201 ( 4.9A)
None
1.46A 1l2iB-5vocE:
undetectable
1l2iB-5vocE:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5)
4 / 5 PHE B 232
LEU B 246
MET A  92
LEU B  56
None
1.48A 1skxA-5vocB:
undetectable
1skxA-5vocB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5)
4 / 8 TYR A  61
CYH B 233
LEU A  96
MET A  92
None
1.46A 1uw6D-5vocA:
undetectable
1uw6E-5vocA:
undetectable
1uw6D-5vocA:
14.07
1uw6E-5vocA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5)
4 / 8 TYR A  61
CYH B 233
LEU A  96
MET A  92
None
1.49A 1uw6G-5vocA:
undetectable
1uw6H-5vocA:
undetectable
1uw6G-5vocA:
14.07
1uw6H-5vocA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5)
4 / 8 TYR A  61
CYH B 233
LEU A  96
MET A  92
None
1.47A 1uw6P-5vocA:
undetectable
1uw6Q-5vocA:
undetectable
1uw6P-5vocA:
14.07
1uw6Q-5vocA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5)
4 / 8 LEU A  96
MET A  92
TYR A  61
CYH B 233
None
1.42A 1uw6P-5vocA:
undetectable
1uw6T-5vocA:
undetectable
1uw6P-5vocA:
14.07
1uw6T-5vocA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
4 / 5 ILE A 597
SER A 577
ARG A 528
LEU A 596
None
1.16A 1y0xX-5vocA:
undetectable
1y0xX-5vocA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
5 / 12 LEU A 348
ALA A 345
LEU A 313
THR A 272
PHE A 250
None
1.46A 2oaxF-5vocA:
undetectable
2oaxF-5vocA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)
5voc ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5)
4 / 5 LEU B 253
PRO B 254
LEU B 257
ILE B 219
None
0.70A 2qd4A-5vocB:
undetectable
2qd4A-5vocB:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
3 / 3 SER A 316
TYR A 320
HIS A 318
None
0.81A 2r2vD-5vocA:
undetectable
2r2vD-5vocA:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)
5voc ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5)
5 / 12 LEU B 123
ASP B 117
THR B 153
GLY B 161
LEU B  82
None
1.20A 2uvnA-5vocB:
undetectable
2uvnA-5vocB:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
5 / 11 ILE A 227
ALA A 341
THR A 337
GLU A 221
LEU A 333
None
1.39A 2v0mD-5vocA:
undetectable
2v0mD-5vocA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
3 / 3 GLU A 466
GLN A 151
ARG A 365
None
0.98A 2w3bB-5vocA:
undetectable
2w3bB-5vocA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)
5voc ENVELOPE
GLYCOPROTEIN UL130

(Human
betaherpesvirus
5)
3 / 3 SER D  67
ARG D  66
GLN D  70
None
0.81A 2xnrA-5vocD:
undetectable
2xnrA-5vocD:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5)
4 / 5 PHE A  90
PHE A  80
LEU B 183
PHE B 222
None
1.15A 2y69C-5vocA:
2.5
2y69J-5vocA:
undetectable
2y69C-5vocA:
15.48
2y69J-5vocA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5)
4 / 5 PHE A  90
PHE A  80
LEU B 183
PHE B 222
None
1.19A 2y69P-5vocA:
2.6
2y69W-5vocA:
undetectable
2y69P-5vocA:
15.48
2y69W-5vocA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
5 / 12 ARG A 188
PHE A 234
ILE A 249
VAL A 236
PHE A 342
None
0.97A 2zznA-5vocA:
undetectable
2zznA-5vocA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5)
4 / 6 PHE A  90
PHE A  80
LEU B 183
PHE B 222
None
1.18A 3ablP-5vocA:
2.6
3ablW-5vocA:
undetectable
3ablP-5vocA:
15.48
3ablW-5vocA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5)
4 / 5 PHE A  90
PHE A  80
LEU B 183
PHE B 222
None
1.14A 3abmC-5vocA:
2.6
3abmJ-5vocA:
undetectable
3abmC-5vocA:
15.48
3abmJ-5vocA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5)
4 / 5 PHE A  90
PHE A  80
LEU B 183
PHE B 222
None
1.16A 3abmP-5vocA:
2.8
3abmW-5vocA:
undetectable
3abmP-5vocA:
15.48
3abmW-5vocA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5)
4 / 5 PHE A  90
PHE A  80
LEU B 183
PHE B 222
None
1.11A 3ag3C-5vocA:
2.5
3ag3J-5vocA:
undetectable
3ag3C-5vocA:
15.48
3ag3J-5vocA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
5 / 12 LEU A 313
PRO A 157
SER A 310
LEU A 148
LEU A 373
None
1.16A 3e23A-5vocA:
undetectable
3e23A-5vocA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
4 / 5 GLN A 151
THR A 153
THR A 414
HIS A 165
None
1.47A 3glqB-5vocA:
undetectable
3glqB-5vocA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5)
4 / 7 GLU B 182
TYR A  45
PHE A  81
TYR A  87
None
1.31A 3ku9B-5vocB:
undetectable
3ku9B-5vocB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)
5voc ENVELOPE
GLYCOPROTEIN UL130
ENVELOPE
GLYCOPROTEIN UL131A

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5)
3 / 3 ASP D 185
SER D 187
ARG E 104
None
1.02A 3loqA-5vocD:
undetectable
3loqA-5vocD:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
3 / 3 SER A 689
SER A 688
HIS A 693
None
0.72A 3mzeA-5vocA:
undetectable
3mzeA-5vocA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
4 / 5 GLN A 151
THR A 153
THR A 414
HIS A 165
None
1.47A 3n58A-5vocA:
undetectable
3n58A-5vocA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
5 / 12 ALA A 351
GLY A 185
SER A 184
ASP A 146
LEU A 309
None
1.22A 3ou6D-5vocA:
undetectable
3ou6D-5vocA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
5 / 12 ALA A 351
GLY A 185
SER A 184
ASP A 146
LEU A 309
None
1.24A 3ou7A-5vocA:
undetectable
3ou7A-5vocA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
5 / 12 ALA A 351
GLY A 185
SER A 184
ASP A 146
LEU A 309
None
1.22A 3ou7D-5vocA:
undetectable
3ou7D-5vocA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
4 / 8 LEU A 348
GLN A 377
TYR A 344
TYR A 396
None
1.19A 3po7A-5vocA:
undetectable
3po7A-5vocA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)
5voc ENVELOPE
GLYCOPROTEIN UL130

(Human
betaherpesvirus
5)
4 / 6 SER D 103
ILE D 111
TYR D  89
THR D  54
None
1.00A 3q70A-5vocD:
undetectable
3q70A-5vocD:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)
5voc ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5)
3 / 3 HIS B 177
ARG B 196
GLU B 198
None
1.04A 3qf1A-5vocB:
undetectable
3qf1A-5vocB:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
4 / 7 LEU A 298
ASP A 299
ALA A 300
TYR A 320
None
1.19A 3rodD-5vocA:
undetectable
3rodD-5vocA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
3 / 3 ASN A 315
ALA A 300
ARG A 319
None
0.88A 3tj7C-5vocA:
undetectable
3tj7D-5vocA:
undetectable
3tj7C-5vocA:
14.67
3tj7D-5vocA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
4 / 6 GLU A 339
PHE A 342
VAL A 128
PHE A 297
None
1.17A 4a97E-5vocA:
3.6
4a97E-5vocA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
4 / 6 ARG A 421
ASP A 517
GLU A 499
LEU A 469
None
1.07A 4ax8A-5vocA:
undetectable
4ax8A-5vocA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
3 / 3 TYR A 306
THR A 272
GLU A 355
None
0.68A 4df3A-5vocA:
undetectable
4df3A-5vocA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
3 / 3 TYR A 306
THR A 272
GLU A 355
None
0.70A 4df3B-5vocA:
undetectable
4df3B-5vocA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)
5voc ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5)
4 / 4 LEU B 253
PRO B 254
LEU B 257
ILE B 219
None
0.82A 4f4dB-5vocB:
undetectable
4f4dB-5vocB:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
4 / 8 LEU A 469
TYR A 468
VAL A 420
HIS A 318
None
0.85A 4l1xA-5vocA:
undetectable
4l1xA-5vocA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5)
4 / 6 LEU A 106
ASN A 107
LEU B  72
VAL B  75
None
1.02A 4okbA-5vocA:
undetectable
4okbA-5vocA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
5 / 9 VAL A 423
LEU A 426
SER A 427
LEU A 473
LEU A 440
None
0.96A 4rs0A-5vocA:
undetectable
4rs0A-5vocA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5)
5 / 12 THR A  69
ASN A  79
ARG B 207
VAL B 191
ILE B 173
None
0.98A 4rvgA-5vocA:
undetectable
4rvgA-5vocA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5)
4 / 6 PHE A  90
PHE A  80
LEU B 183
PHE B 222
None
1.13A 5b1bC-5vocA:
2.5
5b1bJ-5vocA:
undetectable
5b1bC-5vocA:
15.48
5b1bJ-5vocA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5)
3 / 3 ASP B 129
GLU B  94
SER A  68
None
0.71A 5bw4B-5vocB:
undetectable
5bw4B-5vocB:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5)
4 / 5 LEU B 221
PHE B 222
LEU A 106
PHE B 174
None
1.14A 5iy5P-5vocB:
undetectable
5iy5W-5vocB:
undetectable
5iy5P-5vocB:
18.28
5iy5W-5vocB:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
5 / 12 VAL A 423
LEU A 426
SER A 427
LEU A 473
LEU A 440
None
1.13A 5jvzB-5vocA:
undetectable
5jvzB-5vocA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5)
4 / 5 PHE A 138
SER A 139
ASN B 263
ASP A 265
None
1.17A 5kpcA-5vocA:
undetectable
5kpcA-5vocA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
3 / 3 THR A 557
THR A 337
LEU A 218
None
0.69A 5m66D-5vocA:
undetectable
5m66D-5vocA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
5 / 12 VAL A 490
GLU A 486
ALA A 447
ARG A 441
LEU A 440
None
1.11A 5nd4B-5vocA:
undetectable
5nd4B-5vocA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
3 / 3 HIS A 512
HIS A 511
HIS A 509
None
0.86A 5oexA-5vocA:
undetectable
5oexA-5vocA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
4 / 7 LEU A 497
ARG A 534
VAL A 591
SER A 579
None
1.27A 5umwA-5vocA:
undetectable
5umwF-5vocA:
undetectable
5umwA-5vocA:
7.90
5umwF-5vocA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)
5voc ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5)
4 / 8 GLY B 161
ARG B 166
TYR B 169
ASP B 163
None
1.01A 5vlmB-5vocB:
undetectable
5vlmB-5vocB:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5)
4 / 5 PHE A  90
PHE A  80
LEU B 183
PHE B 222
None
1.11A 5wauC-5vocA:
2.7
5wauJ-5vocA:
undetectable
5wauC-5vocA:
15.48
5wauJ-5vocA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5)
4 / 5 PHE A  90
PHE A  80
LEU B 183
PHE B 222
None
1.06A 5wauc-5vocA:
2.7
5wauj-5vocA:
undetectable
5wauc-5vocA:
15.48
5wauj-5vocA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5)
4 / 5 LEU B 221
PHE B 222
LEU A 106
PHE B 174
None
1.07A 5x1fC-5vocB:
undetectable
5x1fJ-5vocB:
undetectable
5x1fC-5vocB:
19.32
5x1fJ-5vocB:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5)
4 / 5 PHE A  90
PHE A  80
LEU B 183
PHE B 222
None
1.10A 5xdqC-5vocA:
2.7
5xdqJ-5vocA:
undetectable
5xdqC-5vocA:
15.48
5xdqJ-5vocA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5)
4 / 5 PHE A  90
PHE A  80
LEU B 183
PHE B 222
None
1.09A 5xdqP-5vocA:
2.6
5xdqW-5vocA:
undetectable
5xdqP-5vocA:
15.48
5xdqW-5vocA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5)
4 / 5 LEU B 221
PHE B 222
LEU A 106
PHE B 174
None
1.08A 5xdxC-5vocB:
undetectable
5xdxJ-5vocB:
undetectable
5xdxC-5vocB:
18.21
5xdxJ-5vocB:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5)
4 / 5 LEU B 221
PHE B 222
LEU A 106
PHE B 174
None
1.17A 5xdxP-5vocB:
undetectable
5xdxW-5vocB:
undetectable
5xdxP-5vocB:
18.21
5xdxW-5vocB:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
5voc ENVELOPE
GLYCOPROTEIN UL130
ENVELOPE
GLYCOPROTEIN UL131A

(Human
betaherpesvirus
5)
5 / 12 PHE E 122
SER D 178
MET D 125
LEU E  56
LEU D 176
None
1.42A 5y2oA-5vocE:
undetectable
5y2oA-5vocE:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
3 / 3 TYR A 135
ARG A 270
THR A 272
None
1.02A 5z84J-5vocA:
undetectable
5z84J-5vocA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5)
4 / 6 PHE A  90
PHE A  80
LEU B 183
PHE B 222
None
1.08A 5z84P-5vocA:
2.5
5z84W-5vocA:
undetectable
5z84P-5vocA:
15.48
5z84W-5vocA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5)
4 / 6 PHE A  90
PHE A  80
LEU B 183
PHE B 222
None
1.07A 5z85P-5vocA:
2.7
5z85W-5vocA:
undetectable
5z85P-5vocA:
15.48
5z85W-5vocA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5)
4 / 6 PHE A  90
PHE A  80
LEU B 183
PHE B 222
None
1.08A 5z86C-5vocA:
2.6
5z86J-5vocA:
undetectable
5z86C-5vocA:
15.48
5z86J-5vocA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5)
4 / 6 PHE A  90
PHE A  80
LEU B 183
PHE B 222
None
1.09A 5z86P-5vocA:
2.3
5z86W-5vocA:
undetectable
5z86P-5vocA:
15.48
5z86W-5vocA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5)
4 / 6 PHE A  90
PHE A  80
LEU B 183
PHE B 222
None
1.09A 5zcoP-5vocA:
2.6
5zcoW-5vocA:
undetectable
5zcoP-5vocA:
15.48
5zcoW-5vocA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5)
4 / 6 PHE A  90
PHE A  80
LEU B 183
PHE B 222
None
1.05A 5zcpC-5vocA:
2.6
5zcpJ-5vocA:
undetectable
5zcpC-5vocA:
15.48
5zcpJ-5vocA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5)
4 / 6 PHE A  90
PHE A  80
LEU B 183
PHE B 222
None
1.06A 5zcpP-5vocA:
undetectable
5zcpW-5vocA:
undetectable
5zcpP-5vocA:
15.48
5zcpW-5vocA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
4 / 8 ILE A 381
THR A 382
THR A 562
SER A 472
None
1.15A 6c06C-5vocA:
2.1
6c06C-5vocA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_A_ADNA505_2
(-)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
4 / 4 GLN A 151
THR A 153
THR A 414
HIS A 165
None
1.50A 6f3nA-5vocA:
undetectable
6f3nA-5vocA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_D_ADND506_2
(-)
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5)
4 / 4 GLN A 151
THR A 153
THR A 414
HIS A 165
None
1.50A 6f3nD-5vocA:
undetectable
6f3nD-5vocA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)
5voc ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5)
4 / 7 ILE B  86
LEU B  82
VAL B 151
LEU B 126
None
0.71A 6g9bA-5vocB:
undetectable
6g9bB-5vocB:
undetectable
6g9bA-5vocB:
17.49
6g9bB-5vocB:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)
5voc ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5)
4 / 6 THR B 108
LEU B 111
THR B 130
LEU B 122
None
1.19A 6mvxA-5vocB:
undetectable
6mvxB-5vocB:
undetectable
6mvxC-5vocB:
undetectable
6mvxA-5vocB:
19.68
6mvxB-5vocB:
19.68
6mvxC-5vocB:
19.68